A multiscale brain network model links Alzheimer’s disease-mediated neuronal hyperactivity to large-scale oscillatory slowing

• Published in: Alzheimer's research & therapy Vol. 14; no. 1; pp. 1 - 20
• Main Authors: van Nifterick, Anne M., Gouw, Alida A., van Kesteren, Ronald E., Scheltens, Philip, Stam, Cornelis J., de Haan, Willem
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 25.07.2022; BioMed Central; BMC
• Subjects: Alzheimer's disease; Brain; Brain research; Computer simulation; Computer-generated environments; Dementia; Development and progression; Electroencephalography; Electrophysiology; Hyperactivity; Hyperexcitability; MEG; Neural circuitry; Neural mass models; Neural oscillations; Neuronal network; Neurons; Oscillatory slowing; Pathophysiology; Physiology; Netherlands

Background Neuronal hyperexcitability and inhibitory interneuron dysfunction are frequently observed in preclinical animal models of Alzheimer's disease (AD). This study investigates whether these microscale abnormalities explain characteristic large-scale magnetoencephalography (MEG) activity...