Percutaneous Absorption of Dexamethasone Acetate and Palmitate, and the Plasma Concentration

• Published in: Chemical & pharmaceutical bulletin Vol. 35; no. 10; pp. 4263 - 4270
• Main Authors: OGISO, TARO, ITO, YOSHIMASA, IWAKI, MASAHIRO, ATAGO, HIDEHIKO, TANAKA, CHIKAKO, MANIWA, NORIKO, ISHIDA, SADAHIRO
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1987; Maruzen; Japan Science and Technology Agency
• Subjects: absorption enhancer; Animals; Applied sciences; Azone; Dexamethasone - analogs & derivatives; Dexamethasone - blood; Dexamethasone - pharmacokinetics; dexamethasone acetate; dexamethasone palmitate; Exact sciences and technology; gel ointment; in vitro release rate; Male; Other techniques and industries; percutaneous absorption; petrolatum ointment; plasma concentration; rat; Rats; Rats, Inbred Strains; Skin Absorption

To investigate quantitatively the percutaneous absorption of dexamethasone acetate (DA) and palmitate (DP), gel and petrolatum ointments were prepared and applied to rat skin. DA in the presence of absorption enhancers (Azone® and sorbitan monooleate) was rapidly absorbed, in the form of dexamethaso...