Critical Role of FoxO3a in Alcohol-Induced Autophagy and Hepatotoxicity

• Published in: The American journal of pathology Vol. 183; no. 6; pp. 1815 - 1825
• Main Authors: Ni, Hong-Min, Du, Kuo, You, Min, Ding, Wen-Xing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2013; American Society for Investigative Pathology
• Subjects: Animals; Autophagy - drug effects; Autophagy - genetics; Central Nervous System Depressants - adverse effects; Central Nervous System Depressants - pharmacology; Enzyme Inhibitors - pharmacology; Ethanol - adverse effects; Ethanol - pharmacology; Fatty Liver - genetics; Fatty Liver - metabolism; Fatty Liver - pathology; Forkhead Box Protein O3; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Gene Expression Regulation; Hepatocytes - metabolism; Hepatocytes - pathology; Liver - metabolism; Liver - pathology; Liver Diseases, Alcoholic - genetics; Liver Diseases, Alcoholic - metabolism; Liver Diseases, Alcoholic - pathology; Mice; Mice, Knockout; Pathology; Regular; Sirtuin 1 - antagonists & inhibitors; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Stilbenes - pharmacology

Autophagy is a lysosomal degradation process that degrades long-lived cellular proteins and damaged organelles as a critical cell survival mechanism in response to stress. We recently reported that acute ethanol induces autophagy, which then reduces ethanol-induced liver injury. However, the mechani...