The humoral immune response to high-dose influenza vaccine in persons with monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL)

• Published in: Vaccine Vol. 39; no. 7; pp. 1122 - 1130
• Main Authors: Whitaker, Jennifer A., Parikh, Sameer A., Shanafelt, Tait D., Kay, Neil E., Kennedy, Richard B., Grill, Diane E., Goergen, Krista M., Call, Timothy G., Kendarian, Saad S., Ding, Wei, Poland, Gregory A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 12.02.2021; Elsevier Limited
• Subjects: absorbents; Adult; Age; Aged; Allergy and Immunology; Antibodies; Antibodies, Viral; B-cell; B-Lymphocytes; blood serum; Blood tests; Chemotherapy; Chronic; Chronic lymphocytic leukemia; Drug dosages; Flow cytometry; hemagglutination; Hemagglutination inhibition; Hemagglutination Inhibition Tests; Humans; humoral immunity; Immune response; Immune response (humoral); Immune system; Immunity, Humoral; Immunogenicity; Immunoglobulins; Immunological memory; Infections; Influenza; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza B; Influenza Vaccines; Influenza, Human - prevention & control; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphatic leukemia; Lymphocytes B; Lymphocytic; lymphocytic leukemia; Lymphocytosis; Medical laboratories; Memory cells; Monoclonal B cell lymphocytosis; Pilot Projects; Population; Prospective Studies; Seasons; Seroconversion; Vaccination; Vaccines; viruses; California; Northern Hemisphere; United States > US; Massachusetts; Influenza vaccines; Lymphocytic; Chronic; B-cell; Influenza; Leukemia; Monoclonal B cell lymphocytosis
• ISSN: 0264-410X; 1873-2518; 1873-2518
• DOI: 10.1016/j.vaccine.2021.01.001

•First published vaccine responses in those with monoclonal B cell lymphocytosis (MBL).•High-dose influenza vaccine responses in MBL and chronic lymphocytic leukemia (CLL).•Seroprotection: 63% (A/H1N1); 91% (A/H3N2); and 43% (B) for cohort (MBL and CLL).•Higher seroprotection rates for influenza B s...