Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

• Published in: Nature cell biology Vol. 22; no. 9; pp. 1064 - 1075
• Main Authors: Gao, Yang, Nihira, Naoe Taira, Bu, Xia, Chu, Chen, Zhang, Jinfang, Kolodziejczyk, Aleksandra, Fan, Yizeng, Chan, Ngai Ting, Ma, Leina, Liu, Jing, Wang, Dong, Dai, Xiaoming, Liu, Huadong, Ono, Masaya, Nakanishi, Akira, Inuzuka, Hiroyuki, North, Brian J., Huang, Yu-Han, Sharma, Samanta, Geng, Yan, Xu, Wei, Liu, X. Shirley, Li, Lei, Miki, Yoshio, Sicinski, Piotr, Freeman, Gordon J., Wei, Wenyi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2020; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/109; 13/31; 13/95; 14/19; 38/23; 38/91; 631/250/580; 631/67/1059/2325; 631/80/458/1275; 692/699/67; 82; 82/58; 82/83; 96; Acetylation; Animals; Apoptosis; B7-H1 Antigen - metabolism; Biomedical and Life Sciences; Cancer Research; Cell Biology; Cell death; Cell Line; Cell Line, Tumor; Cell Nucleus - metabolism; Cellular proteins; CTLA-4 protein; Cytotoxicity; Deacetylation; Developmental Biology; E1A-Associated p300 Protein - metabolism; Endocytosis; Gene expression; Gene Expression - physiology; Genes; HDAC2 protein; Health aspects; HEK293 Cells; Histone deacetylase; Humans; Immune checkpoint; Immune system; Immunotherapy; Immunotherapy - methods; Life Sciences; Localization; Lymphocytes; Lymphocytes T; MCF-7 Cells; Medical research; Medicine, Experimental; Mice; Neoplasms - metabolism; Nuclear transport; PD-1 protein; PD-L1 protein; Programmed Cell Death 1 Receptor - metabolism; Protein Processing, Post-Translational - physiology; Proteins; RAW 264.7 Cells; Stem Cells; Translocation; Translocation (Genetics); Tumors; United States

Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive clinical outcomes for multiple tumours. However, only a subset of patients achieves durable responses, suggesting that the mech...