Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy - Gao, Yang; Nihira, Naoe Taira; Bu, Xia; Chu, Chen; Zhang, Jinfang; Kolodziejczyk, Aleksandra; Fan, Yizeng; Chan, Ngai Ting; Ma, Leina; Liu, Jing; Wang, Dong; Dai, Xiaoming; et al. (Nature cell biology, 2020)
Keywords: 13/1; 13/106; 13/109; 13/31; 13/95; 14/19; 38/23; 38/91; 631/250/580; 631/67/1059/2325; 631/80/458/1275; 692/699/67; 82; 82/58; 82/83; 96; Acetylation; Animals; Apoptosis; B7-H1 Antigen - metabolism; Biomedical and Life Sciences; Cancer Research; Cell Biology; Cell death; Cell Line; Cell Line, Tumor; Cell Nucleus - metabolism; Cellular proteins; CTLA-4 protein; Cytotoxicity; Deacetylation; Developmental Biology; E1A-Associated p300 Protein - metabolism; Endocytosis; Gene expression; Gene Expression - physiology; Genes; HDAC2 protein; Health aspects; HEK293 Cells; Histone deacetylase; Humans; Immune checkpoint; Immune system; Immunotherapy; Immunotherapy - methods; Life Sciences; Localization; Lymphocytes; Lymphocytes T; MCF-7 Cells; Medical research; Medicine, Experimental; Mice; Neoplasms - metabolism; Nuclear transport; PD-1 protein; PD-L1 protein; Programmed Cell Death 1 Receptor - metabolism; Protein Processing, Post-Translational - physiology; Proteins; RAW 264.7 Cells; Stem Cells; Translocation; Translocation (Genetics); Tumors; United States