Dynamic changes of pulmonary diffusion capacity in survivors of non-critical COVID-19 during the first six months
The dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to describe the changes of lung function and identify risk factors for impaired diffusion capacity. Non-critical COVID-19 patients admitted to the Guangzhou...
Saved in:
| Published in | EClinicalMedicine Vol. 43; p. 101255 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.01.2022
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to describe the changes of lung function and identify risk factors for impaired diffusion capacity.
Non-critical COVID-19 patients admitted to the Guangzhou Eighth People's Hospital, China, were enrolled from March to June 2020. Subjects were prospectively followed up with pulmonary function tests at discharge, three and six months after discharge.
Eighty-six patients completed diffusion capacity tests at three timepoints. The mean diffusion capacity for carbon monoxide (DLCO)% pred was 79.8% at discharge and significantly improved to 84.9% at Month-3. The transfer coefficient of the lung for carbon monoxide (KCO)% pred significantly increased from 91.7% at discharge to 95.7% at Month-3. Both of them showed no further improvement at Month-6. The change rates of DLCO% pred and KCO% pred were significantly higher in 0–3 months than in 3–6 months. The alveolar ventilation (VA) improved continuously during the follow-ups. At Month-6, impaired DLCO% pred was associated with being female (OR 5.2 [1.7–15.8]; p = 0.004) and peak total lesion score (TLS) of chest CT > 8.5 (OR 6.6 [1.7–26.5]; p = 0.007). DLCO% pred and KCO% pred were worse in females at discharge. And in patients with impaired diffusion capacity, females’ DLCO% pred recovered slower than males.
The first three months is the critical recovery period for diffusion capacity. The impaired diffusion capacity was more severe and recovered slower in females than in males. Early pulmonary rehabilitation and individualized interventions for recovery are worthy of further investigations. |
|---|---|
| AbstractList | SummaryBackgroundThe dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to describe the changes of lung function and identify risk factors for impaired diffusion capacity. MethodsNon-critical COVID-19 patients admitted to the Guangzhou Eighth People's Hospital, China, were enrolled from March to June 2020. Subjects were prospectively followed up with pulmonary function tests at discharge, three and six months after discharge. FindingsEighty-six patients completed diffusion capacity tests at three timepoints. The mean diffusion capacity for carbon monoxide (D LCO)% pred was 79.8% at discharge and significantly improved to 84.9% at Month-3. The transfer coefficient of the lung for carbon monoxide (K CO)% pred significantly increased from 91.7% at discharge to 95.7% at Month-3. Both of them showed no further improvement at Month-6. The change rates of D LCO% pred and K CO% pred were significantly higher in 0–3 months than in 3–6 months. The alveolar ventilation (V A) improved continuously during the follow-ups. At Month-6, impaired D LCO% pred was associated with being female (OR 5.2 [1.7–15.8]; p = 0.004) and peak total lesion score (TLS) of chest CT > 8.5 (OR 6.6 [1.7–26.5]; p = 0.007). D LCO% pred and K CO% pred were worse in females at discharge. And in patients with impaired diffusion capacity, females’ D LCO% pred recovered slower than males. InterpretationThe first three months is the critical recovery period for diffusion capacity. The impaired diffusion capacity was more severe and recovered slower in females than in males. Early pulmonary rehabilitation and individualized interventions for recovery are worthy of further investigations. The dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to describe the changes of lung function and identify risk factors for impaired diffusion capacity.BACKGROUNDThe dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to describe the changes of lung function and identify risk factors for impaired diffusion capacity.Non-critical COVID-19 patients admitted to the Guangzhou Eighth People's Hospital, China, were enrolled from March to June 2020. Subjects were prospectively followed up with pulmonary function tests at discharge, three and six months after discharge.METHODSNon-critical COVID-19 patients admitted to the Guangzhou Eighth People's Hospital, China, were enrolled from March to June 2020. Subjects were prospectively followed up with pulmonary function tests at discharge, three and six months after discharge.Eighty-six patients completed diffusion capacity tests at three timepoints. The mean diffusion capacity for carbon monoxide (DLCO)% pred was 79.8% at discharge and significantly improved to 84.9% at Month-3. The transfer coefficient of the lung for carbon monoxide (KCO)% pred significantly increased from 91.7% at discharge to 95.7% at Month-3. Both of them showed no further improvement at Month-6. The change rates of DLCO% pred and KCO% pred were significantly higher in 0-3 months than in 3-6 months. The alveolar ventilation (VA) improved continuously during the follow-ups. At Month-6, impaired DLCO% pred was associated with being female (OR 5.2 [1.7-15.8]; p = 0.004) and peak total lesion score (TLS) of chest CT > 8.5 (OR 6.6 [1.7-26.5]; p = 0.007). DLCO% pred and KCO% pred were worse in females at discharge. And in patients with impaired diffusion capacity, females' DLCO% pred recovered slower than males.FINDINGSEighty-six patients completed diffusion capacity tests at three timepoints. The mean diffusion capacity for carbon monoxide (DLCO)% pred was 79.8% at discharge and significantly improved to 84.9% at Month-3. The transfer coefficient of the lung for carbon monoxide (KCO)% pred significantly increased from 91.7% at discharge to 95.7% at Month-3. Both of them showed no further improvement at Month-6. The change rates of DLCO% pred and KCO% pred were significantly higher in 0-3 months than in 3-6 months. The alveolar ventilation (VA) improved continuously during the follow-ups. At Month-6, impaired DLCO% pred was associated with being female (OR 5.2 [1.7-15.8]; p = 0.004) and peak total lesion score (TLS) of chest CT > 8.5 (OR 6.6 [1.7-26.5]; p = 0.007). DLCO% pred and KCO% pred were worse in females at discharge. And in patients with impaired diffusion capacity, females' DLCO% pred recovered slower than males.The first three months is the critical recovery period for diffusion capacity. The impaired diffusion capacity was more severe and recovered slower in females than in males. Early pulmonary rehabilitation and individualized interventions for recovery are worthy of further investigations.INTERPRETATIONThe first three months is the critical recovery period for diffusion capacity. The impaired diffusion capacity was more severe and recovered slower in females than in males. Early pulmonary rehabilitation and individualized interventions for recovery are worthy of further investigations. Background: The dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to describe the changes of lung function and identify risk factors for impaired diffusion capacity. Methods: Non-critical COVID-19 patients admitted to the Guangzhou Eighth People's Hospital, China, were enrolled from March to June 2020. Subjects were prospectively followed up with pulmonary function tests at discharge, three and six months after discharge. Findings: Eighty-six patients completed diffusion capacity tests at three timepoints. The mean diffusion capacity for carbon monoxide (DLCO)% pred was 79.8% at discharge and significantly improved to 84.9% at Month-3. The transfer coefficient of the lung for carbon monoxide (KCO)% pred significantly increased from 91.7% at discharge to 95.7% at Month-3. Both of them showed no further improvement at Month-6. The change rates of DLCO% pred and KCO% pred were significantly higher in 0–3 months than in 3–6 months. The alveolar ventilation (VA) improved continuously during the follow-ups. At Month-6, impaired DLCO% pred was associated with being female (OR 5.2 [1.7–15.8]; p = 0.004) and peak total lesion score (TLS) of chest CT > 8.5 (OR 6.6 [1.7–26.5]; p = 0.007). DLCO% pred and KCO% pred were worse in females at discharge. And in patients with impaired diffusion capacity, females’ DLCO% pred recovered slower than males. Interpretation: The first three months is the critical recovery period for diffusion capacity. The impaired diffusion capacity was more severe and recovered slower in females than in males. Early pulmonary rehabilitation and individualized interventions for recovery are worthy of further investigations. The dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to describe the changes of lung function and identify risk factors for impaired diffusion capacity. Non-critical COVID-19 patients admitted to the Guangzhou Eighth People's Hospital, China, were enrolled from March to June 2020. Subjects were prospectively followed up with pulmonary function tests at discharge, three and six months after discharge. Eighty-six patients completed diffusion capacity tests at three timepoints. The mean diffusion capacity for carbon monoxide (DLCO)% pred was 79.8% at discharge and significantly improved to 84.9% at Month-3. The transfer coefficient of the lung for carbon monoxide (KCO)% pred significantly increased from 91.7% at discharge to 95.7% at Month-3. Both of them showed no further improvement at Month-6. The change rates of DLCO% pred and KCO% pred were significantly higher in 0–3 months than in 3–6 months. The alveolar ventilation (VA) improved continuously during the follow-ups. At Month-6, impaired DLCO% pred was associated with being female (OR 5.2 [1.7–15.8]; p = 0.004) and peak total lesion score (TLS) of chest CT > 8.5 (OR 6.6 [1.7–26.5]; p = 0.007). DLCO% pred and KCO% pred were worse in females at discharge. And in patients with impaired diffusion capacity, females’ DLCO% pred recovered slower than males. The first three months is the critical recovery period for diffusion capacity. The impaired diffusion capacity was more severe and recovered slower in females than in males. Early pulmonary rehabilitation and individualized interventions for recovery are worthy of further investigations. The dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to describe the changes of lung function and identify risk factors for impaired diffusion capacity. Non-critical COVID-19 patients admitted to the Guangzhou Eighth People's Hospital, China, were enrolled from March to June 2020. Subjects were prospectively followed up with pulmonary function tests at discharge, three and six months after discharge. Eighty-six patients completed diffusion capacity tests at three timepoints. The mean diffusion capacity for carbon monoxide (D )% pred was 79.8% at discharge and significantly improved to 84.9% at Month-3. The transfer coefficient of the lung for carbon monoxide (K )% pred significantly increased from 91.7% at discharge to 95.7% at Month-3. Both of them showed no further improvement at Month-6. The change rates of D % pred and K % pred were significantly higher in 0-3 months than in 3-6 months. The alveolar ventilation (V ) improved continuously during the follow-ups. At Month-6, impaired D % pred was associated with being female (OR 5.2 [1.7-15.8]; = 0.004) and peak total lesion score (TLS) of chest CT > 8.5 (OR 6.6 [1.7-26.5]; = 0.007). D % pred and K % pred were worse in females at discharge. And in patients with impaired diffusion capacity, females' D % pred recovered slower than males. The first three months is the critical recovery period for diffusion capacity. The impaired diffusion capacity was more severe and recovered slower in females than in males. Early pulmonary rehabilitation and individualized interventions for recovery are worthy of further investigations. |
| ArticleNumber | 101255 |
| Author | Peng, Ping Zhou, Yuqi Zhong, Shuxin Li, Shiyue Jian, Wenhua Du, Sheng Gao, Yi Liu, Jingwei Zhong, Nanshan Chen, Ruchong Mo, Xiaoneng Yu, Yanhui Chen, Mu Deng, Xilong Fang, Liman Peng, Hui |
| Author_xml | – sequence: 1 givenname: Mu surname: Chen fullname: Chen, Mu organization: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, China – sequence: 2 givenname: Jingwei surname: Liu fullname: Liu, Jingwei organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China – sequence: 3 givenname: Ping surname: Peng fullname: Peng, Ping organization: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, China – sequence: 4 givenname: Wenhua surname: Jian fullname: Jian, Wenhua organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China – sequence: 5 givenname: Yi surname: Gao fullname: Gao, Yi organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China – sequence: 6 givenname: Liman surname: Fang fullname: Fang, Liman organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China – sequence: 7 givenname: Yanhui surname: Yu fullname: Yu, Yanhui organization: Guangdong Second Provincial General Hospital, Guangzhou 510317, China – sequence: 8 givenname: Shuxin surname: Zhong fullname: Zhong, Shuxin organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China – sequence: 9 givenname: Hui surname: Peng fullname: Peng, Hui organization: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, China – sequence: 10 givenname: Xilong surname: Deng fullname: Deng, Xilong organization: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, China – sequence: 11 givenname: Yuqi surname: Zhou fullname: Zhou, Yuqi organization: The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China – sequence: 12 givenname: Sheng surname: Du fullname: Du, Sheng organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China – sequence: 13 givenname: Ruchong surname: Chen fullname: Chen, Ruchong email: chen_rch@163.com organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China – sequence: 14 givenname: Xiaoneng surname: Mo fullname: Mo, Xiaoneng email: moxiaoneng@126.com organization: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, China – sequence: 15 givenname: Nanshan surname: Zhong fullname: Zhong, Nanshan email: nanshan@vip.163.com organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China – sequence: 16 givenname: Shiyue surname: Li fullname: Li, Shiyue email: lishiyue@188.com organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35018338$$D View this record in MEDLINE/PubMed |
| BookMark | eNqVkttuEzEQhleoiJbSN0DIl9xs8XEPCCGhlEOkSr3gcGvZ3nHisLFTezcib483CVWLhCqubI3_-WY88z8vTnzwUBQvCb4kmFRvVpdgeufXlxRTMoWoEE-KMyqathSsxif37qfFRUorjDHFvGkr_Kw4ZQKThrHmrLi92nm1dgaZpfILSChYtBn7dfAq7lDnrB2TCx4ZtVHGDTvkPEpj3LptiHtxbqw00Q3OqB7Nbn7Mr0rSom6Mzi_QsARkXUwDSu4XytBhmV4UT63qE1wcz_Pi-6eP32Zfyuubz_PZh-vSVKweSmLrSleVoIxzIE1LbcexZrXBDddGYMu1FqTltsGAVcsUKN5apnTLNFhds_NifuB2Qa3kJrp1_pEMysl9IMSFVDG33YOkjNS2aTXnNXBlKm0ptA3TghElBFeZ9f7A2ox6DZ0BP0TVP4A-fPFuKRdhK5uaiYbhDHh9BMRwO0Ia5NolA32vPIQxSVqRlhLSVk2Wvrpf667In51lAT8ITAwpRbB3EoLl5A65kgd3yMkd8uCOnPb2r7S8TzXk5eaOXf9Y8nEAkDe2dRBlMg68gc5FMEMeqftfwKSZTPMTdpBWYYw-u0ESmajE8uvk3sm8lGAs2H4s7_4NeLz-b5KGAYM |
| CitedBy_id | crossref_primary_10_1038_s41598_023_43710_w crossref_primary_10_7759_cureus_58897 crossref_primary_10_23736_S1973_9087_22_07593_1 crossref_primary_10_1016_j_eclinm_2022_101668 crossref_primary_10_2139_ssrn_4155228 crossref_primary_10_1111_joim_13614 crossref_primary_10_1093_ofid_ofac596 crossref_primary_10_1016_j_eclinm_2022_101473 crossref_primary_10_7759_cureus_53492 crossref_primary_10_1002_jmv_29566 crossref_primary_10_31893_multiscience_2025403 crossref_primary_10_1016_j_arbres_2022_03_006 crossref_primary_10_1016_j_resmer_2023_101001 crossref_primary_10_1186_s12931_023_02344_2 crossref_primary_10_2147_JIR_S371283 crossref_primary_10_3390_jcm13010045 |
| Cites_doi | 10.1378/chest.128.4.2247 10.1111/all.14496 10.3346/jkms.2018.33.e169 10.1111/j.1440-1843.2010.01720.x 10.1164/rccm.201908-1590ST 10.1183/13993003.02194-2020 10.1016/S0140-6736(21)01755-4 10.1016/S2213-2600(21)00174-0 10.1016/j.rmed.2020.106272 10.1093/bib/bbab118 10.1016/j.chest.2021.02.062 10.1016/j.rmed.2020.106197 10.1016/j.cmi.2020.09.023 10.1038/s41598-020-74497-9 10.1016/j.ctcp.2020.101166 10.1148/radiol.2020200370 10.1148/radiol.2462070712 10.1378/chest.128.3.1393 10.1016/j.jinf.2021.05.034 10.1136/thx.54.7.581 10.1001/jamanetworkopen.2020.36142 10.1016/S0140-6736(20)32656-8 10.1183/13993003.03677-2020 10.1136/thoraxjnl-2020-216308 10.1164/rccm.201112-2160CI 10.1038/s41586-020-2700-3 10.1183/13993003.01217-2020 |
| ContentType | Journal Article |
| Copyright | 2021 The Authors The Authors 2021 The Authors. 2021 The Authors 2021 |
| Copyright_xml | – notice: 2021 The Authors – notice: The Authors – notice: 2021 The Authors. – notice: 2021 The Authors 2021 |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.1016/j.eclinm.2021.101255 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2589-5370 |
| EndPage | 101255 |
| ExternalDocumentID | oai_doaj_org_article_2317f89b447e4ac6bf2e983b531a554a PMC8735830 35018338 10_1016_j_eclinm_2021_101255 S2589537021005368 1_s2_0_S2589537021005368 |
| Genre | Journal Article |
| GroupedDBID | .1- .FO 0R~ 53G AAEDW AALRI AAMRU AAXUO AAYWO ABMAC ACLIJ ACVFH ADBBV ADCNI ADVLN AEUPX AEXQZ AFPUW AFRHN AFTJW AIGII AITUG AJUYK AKBMS AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS APXCP BCNDV EBS EJD FDB GROUPED_DOAJ HYE M41 OK1 ROL RPM SSZ Z5R 0SF 6I. AACTN NCXOZ AAFTH AFCTW AAYXX CITATION NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c637t-1f76b6652344e1892fd40b37c084bc50f4bb5194f80e0a93aea49f3ab93befb73 |
| IEDL.DBID | DOA |
| ISSN | 2589-5370 |
| IngestDate | Wed Aug 27 01:26:24 EDT 2025 Thu Aug 21 13:56:09 EDT 2025 Thu Jul 10 22:44:27 EDT 2025 Thu Jan 02 22:54:07 EST 2025 Thu Apr 24 23:09:00 EDT 2025 Tue Jul 01 01:50:23 EDT 2025 Tue Jul 25 20:56:45 EDT 2023 Tue Feb 25 20:04:35 EST 2025 Tue Aug 26 20:24:25 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | COVID-19 Pulmonary diffusion capacity Dynamic changes |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. 2021 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c637t-1f76b6652344e1892fd40b37c084bc50f4bb5194f80e0a93aea49f3ab93befb73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. These authors contributed equally to this article as corresponding authors and supervised the work. |
| OpenAccessLink | https://doaj.org/article/2317f89b447e4ac6bf2e983b531a554a |
| PMID | 35018338 |
| PQID | 2619211968 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_2317f89b447e4ac6bf2e983b531a554a pubmedcentral_primary_oai_pubmedcentral_nih_gov_8735830 proquest_miscellaneous_2619211968 pubmed_primary_35018338 crossref_primary_10_1016_j_eclinm_2021_101255 crossref_citationtrail_10_1016_j_eclinm_2021_101255 elsevier_sciencedirect_doi_10_1016_j_eclinm_2021_101255 elsevier_clinicalkeyesjournals_1_s2_0_S2589537021005368 elsevier_clinicalkey_doi_10_1016_j_eclinm_2021_101255 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-01-01 |
| PublicationDateYYYYMMDD | 2022-01-01 |
| PublicationDate_xml | – month: 01 year: 2022 text: 2022-01-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | EClinicalMedicine |
| PublicationTitleAlternate | EClinicalMedicine |
| PublicationYear | 2022 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
| References | Zhang, Cao, Tan (bib0028) 2021; 76 Fortini, Torrigiani, Sbaragli (bib0006) 2021 Yan, Huang, Wang (bib0010) 2021; 83 Hansell, Bankier, MacMahon, McLoud, Müller, Remy (bib0021) 2008; 246 Huang, Yao, Gu (bib0026) 2021; 398 Wu, Liu, Zhou (bib0013) 2021; 9 González, Benítez, Carmona (bib0005) 2021; 160 Cao, Han, Gu (bib0023) 2020; 10 Mo, Jian, Su (bib0007) 2020; 55 Shah, Wong, Hague (bib0009) 2021; 76 National Health Commission & State Administration of Traditional Chinese Medicine. Diagnosis and treatment protocol for novel coronavirus pneumonia. Graham, Steenbruggen, Miller (bib0020) 2019; 200 WHO. Coronavirus disease (COVID-19) pandemic. Hughes, Pride (bib0024) 2012; 186 Ong, Ng, Lee (bib0016) 2005; 128 Hui, Wong, Ko (bib0014) 2005; 128 Pan, Ye, Sun (bib0022) 2020; 295 Takahashi, Ellingson, Wong (bib0029) 2020; 588 Chen, Gao, Chen (bib0025) 2020; 56 Xiong, Xu, Li (bib0002) 2021; 27 Date last accessed: August 30, 2021. Bestall, Paul, Garrod, Garnham, Jones, Wedzicha (bib0019) 1999; 54 Qin, Xu, Wang (bib0030) 2021 Liu, Zhang, Yang, Zhang, Li, Chen (bib0027) 2020; 39 Huang, Huang, Wang (bib0012) 2021; 397 van der Sar-van der Brugge, Talman, Boonman-de Winter (bib0011) 2021; 176 Qin, Chen, Zhang (bib0008) 2021; 58 Park, Jun, Kim (bib0017) 2018; 33 Daher, Balfanz, Cornelissen (bib0004) 2020; 174 Bellan, Soddu, Balbo (bib0003) 2021; 4 Ngai, Ko, Ng, To, Tong, Hui (bib0015) 2010; 15 Date last updated: March 3, 2020. Date last assessed: August 17, 2021. Liu (10.1016/j.eclinm.2021.101255_bib0027) 2020; 39 Takahashi (10.1016/j.eclinm.2021.101255_bib0029) 2020; 588 Bellan (10.1016/j.eclinm.2021.101255_bib0003) 2021; 4 Shah (10.1016/j.eclinm.2021.101255_bib0009) 2021; 76 Qin (10.1016/j.eclinm.2021.101255_bib0030) 2021 Mo (10.1016/j.eclinm.2021.101255_bib0007) 2020; 55 Hui (10.1016/j.eclinm.2021.101255_bib0014) 2005; 128 10.1016/j.eclinm.2021.101255_bib0001 Zhang (10.1016/j.eclinm.2021.101255_bib0028) 2021; 76 Hughes (10.1016/j.eclinm.2021.101255_bib0024) 2012; 186 González (10.1016/j.eclinm.2021.101255_bib0005) 2021; 160 Huang (10.1016/j.eclinm.2021.101255_bib0012) 2021; 397 Cao (10.1016/j.eclinm.2021.101255_bib0023) 2020; 10 10.1016/j.eclinm.2021.101255_bib0018 Graham (10.1016/j.eclinm.2021.101255_bib0020) 2019; 200 Chen (10.1016/j.eclinm.2021.101255_bib0025) 2020; 56 Xiong (10.1016/j.eclinm.2021.101255_bib0002) 2021; 27 Huang (10.1016/j.eclinm.2021.101255_bib0026) 2021; 398 Yan (10.1016/j.eclinm.2021.101255_bib0010) 2021; 83 Park (10.1016/j.eclinm.2021.101255_bib0017) 2018; 33 Hansell (10.1016/j.eclinm.2021.101255_bib0021) 2008; 246 Wu (10.1016/j.eclinm.2021.101255_bib0013) 2021; 9 Ong (10.1016/j.eclinm.2021.101255_bib0016) 2005; 128 van der Sar-van der Brugge (10.1016/j.eclinm.2021.101255_bib0011) 2021; 176 Daher (10.1016/j.eclinm.2021.101255_bib0004) 2020; 174 Bestall (10.1016/j.eclinm.2021.101255_bib0019) 1999; 54 Fortini (10.1016/j.eclinm.2021.101255_bib0006) 2021 Ngai (10.1016/j.eclinm.2021.101255_bib0015) 2010; 15 Pan (10.1016/j.eclinm.2021.101255_bib0022) 2020; 295 Qin (10.1016/j.eclinm.2021.101255_bib0008) 2021; 58 |
| References_xml | – volume: 397 start-page: 220 year: 2021 end-page: 232 ident: bib0012 article-title: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study publication-title: Lancet – volume: 54 start-page: 581 year: 1999 end-page: 586 ident: bib0019 article-title: Usefulness of the medical research council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease publication-title: Thorax – start-page: 1 year: 2021 end-page: 9 ident: bib0006 article-title: COVID-19: persistence of symptoms and lung alterations after 3-6 months from hospital discharge publication-title: Infection – volume: 33 start-page: e169 year: 2018 ident: bib0017 article-title: Correlation between pneumonia severity and pulmonary complications in middle east respiratory syndrome publication-title: J Korean Med Sci – volume: 10 start-page: 17543 year: 2020 ident: bib0023 article-title: Prognostic value of baseline clinical and HRCT findings in 101 patients with severe COVID-19 in Wuhan, China publication-title: Sci Rep – volume: 160 start-page: 187 year: 2021 end-page: 198 ident: bib0005 article-title: Pulmonary function and radiologic features in survivors of critical COVID-19: a 3-month prospective cohort publication-title: Chest – volume: 186 start-page: 132 year: 2012 end-page: 139 ident: bib0024 article-title: Examination of the carbon monoxide diffusing capacity (DL(CO)) in relation to its K publication-title: Am J Respir Crit Care Med – volume: 128 start-page: 1393 year: 2005 end-page: 1400 ident: bib0016 article-title: 1-year pulmonary function and health status in survivors of severe acute respiratory syndrome publication-title: Chest – volume: 588 start-page: 315 year: 2020 end-page: 320 ident: bib0029 article-title: Sex differences in immune responses that underlie COVID-19 disease outcomes publication-title: Nature – volume: 55 year: 2020 ident: bib0007 article-title: Abnormal pulmonary function in COVID-19 patients at time of hospital discharge publication-title: Eur Respir J – volume: 174 year: 2020 ident: bib0004 article-title: Follow up of patients with severe coronavirus disease 2019 (COVID-19): pulmonary and extrapulmonary disease sequelae publication-title: Respir Med – volume: 76 start-page: 402 year: 2021 end-page: 404 ident: bib0009 article-title: A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations publication-title: Thorax – volume: 176 year: 2021 ident: bib0011 article-title: Pulmonary function and health-related quality of life after COVID-19 pneumonia publication-title: Respir Med – volume: 15 start-page: 543 year: 2010 end-page: 550 ident: bib0015 article-title: The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status publication-title: Respirology – reference: . Date last updated: March 3, 2020. Date last assessed: August 17, 2021. – volume: 27 start-page: 89 year: 2021 end-page: 95 ident: bib0002 article-title: Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study publication-title: Clin Microbiol Infect – reference: WHO. Coronavirus disease (COVID-19) pandemic. – year: 2021 ident: bib0030 article-title: Analyzing master regulators and scRNA-seq of COVID-19 patients reveals an underlying anti-SARS-CoV-2 mechanism of ZNF proteins publication-title: Brief Bioinform – volume: 4 year: 2021 ident: bib0003 article-title: Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge publication-title: JAMA Netw Open – reference: . Date last accessed: August 30, 2021. – volume: 76 start-page: 533 year: 2021 end-page: 550 ident: bib0028 article-title: Clinical, radiological, and laboratory characteristics and risk factors for severity and mortality of 289 hospitalized COVID-19 patients publication-title: Allergy – volume: 246 start-page: 697 year: 2008 end-page: 722 ident: bib0021 article-title: Fleischner society: glossary of terms for thoracic imaging publication-title: Radiology – volume: 39 year: 2020 ident: bib0027 article-title: Respiratory rehabilitation in elderly patients with COVID-19: a randomized controlled study publication-title: Complement Ther Clin Pract – volume: 56 year: 2020 ident: bib0025 article-title: Impaired pulmonary function in discharged patients with COVID-19: more work ahead publication-title: Eur Respir J – volume: 58 year: 2021 ident: bib0008 article-title: Diffusion capacity abnormalities for carbon monoxide in patients with COVID-19 at 3-month follow-up publication-title: Eur Respir J – reference: National Health Commission & State Administration of Traditional Chinese Medicine. Diagnosis and treatment protocol for novel coronavirus pneumonia. – volume: 9 start-page: 747 year: 2021 end-page: 754 ident: bib0013 article-title: 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study publication-title: Lancet Respir Med – volume: 295 start-page: 715 year: 2020 end-page: 721 ident: bib0022 article-title: Time course of lung changes at chest ct during recovery from coronavirus disease 2019 (COVID-19) publication-title: Radiology – volume: 200 start-page: e70 year: 2019 end-page: e88 ident: bib0020 publication-title: Am J Respir Crit Care Med – volume: 398 start-page: 747 year: 2021 end-page: 758 ident: bib0026 article-title: 1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study publication-title: Lancet – volume: 128 start-page: 2247 year: 2005 end-page: 2261 ident: bib0014 article-title: The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors publication-title: Chest – volume: 83 start-page: 381 year: 2021 end-page: 412 ident: bib0010 article-title: Follow-up study of pulmonary function among COVID-19 survivors 1 year after recovery publication-title: J Infect – ident: 10.1016/j.eclinm.2021.101255_bib0018 – volume: 128 start-page: 2247 year: 2005 ident: 10.1016/j.eclinm.2021.101255_bib0014 article-title: The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors publication-title: Chest doi: 10.1378/chest.128.4.2247 – volume: 76 start-page: 533 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0028 article-title: Clinical, radiological, and laboratory characteristics and risk factors for severity and mortality of 289 hospitalized COVID-19 patients publication-title: Allergy doi: 10.1111/all.14496 – volume: 33 start-page: e169 year: 2018 ident: 10.1016/j.eclinm.2021.101255_bib0017 article-title: Correlation between pneumonia severity and pulmonary complications in middle east respiratory syndrome publication-title: J Korean Med Sci doi: 10.3346/jkms.2018.33.e169 – volume: 15 start-page: 543 year: 2010 ident: 10.1016/j.eclinm.2021.101255_bib0015 article-title: The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status publication-title: Respirology doi: 10.1111/j.1440-1843.2010.01720.x – ident: 10.1016/j.eclinm.2021.101255_bib0001 – volume: 200 start-page: e70 year: 2019 ident: 10.1016/j.eclinm.2021.101255_bib0020 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201908-1590ST – volume: 56 year: 2020 ident: 10.1016/j.eclinm.2021.101255_bib0025 article-title: Impaired pulmonary function in discharged patients with COVID-19: more work ahead publication-title: Eur Respir J doi: 10.1183/13993003.02194-2020 – volume: 398 start-page: 747 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0026 article-title: 1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study publication-title: Lancet doi: 10.1016/S0140-6736(21)01755-4 – volume: 9 start-page: 747 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0013 article-title: 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study publication-title: Lancet Respir Med doi: 10.1016/S2213-2600(21)00174-0 – volume: 176 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0011 article-title: Pulmonary function and health-related quality of life after COVID-19 pneumonia publication-title: Respir Med doi: 10.1016/j.rmed.2020.106272 – year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0030 article-title: Analyzing master regulators and scRNA-seq of COVID-19 patients reveals an underlying anti-SARS-CoV-2 mechanism of ZNF proteins publication-title: Brief Bioinform doi: 10.1093/bib/bbab118 – volume: 160 start-page: 187 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0005 article-title: Pulmonary function and radiologic features in survivors of critical COVID-19: a 3-month prospective cohort publication-title: Chest doi: 10.1016/j.chest.2021.02.062 – volume: 174 year: 2020 ident: 10.1016/j.eclinm.2021.101255_bib0004 article-title: Follow up of patients with severe coronavirus disease 2019 (COVID-19): pulmonary and extrapulmonary disease sequelae publication-title: Respir Med doi: 10.1016/j.rmed.2020.106197 – volume: 27 start-page: 89 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0002 article-title: Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study publication-title: Clin Microbiol Infect doi: 10.1016/j.cmi.2020.09.023 – volume: 10 start-page: 17543 year: 2020 ident: 10.1016/j.eclinm.2021.101255_bib0023 article-title: Prognostic value of baseline clinical and HRCT findings in 101 patients with severe COVID-19 in Wuhan, China publication-title: Sci Rep doi: 10.1038/s41598-020-74497-9 – start-page: 1 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0006 article-title: COVID-19: persistence of symptoms and lung alterations after 3-6 months from hospital discharge publication-title: Infection – volume: 39 year: 2020 ident: 10.1016/j.eclinm.2021.101255_bib0027 article-title: Respiratory rehabilitation in elderly patients with COVID-19: a randomized controlled study publication-title: Complement Ther Clin Pract doi: 10.1016/j.ctcp.2020.101166 – volume: 295 start-page: 715 year: 2020 ident: 10.1016/j.eclinm.2021.101255_bib0022 article-title: Time course of lung changes at chest ct during recovery from coronavirus disease 2019 (COVID-19) publication-title: Radiology doi: 10.1148/radiol.2020200370 – volume: 246 start-page: 697 year: 2008 ident: 10.1016/j.eclinm.2021.101255_bib0021 article-title: Fleischner society: glossary of terms for thoracic imaging publication-title: Radiology doi: 10.1148/radiol.2462070712 – volume: 128 start-page: 1393 year: 2005 ident: 10.1016/j.eclinm.2021.101255_bib0016 article-title: 1-year pulmonary function and health status in survivors of severe acute respiratory syndrome publication-title: Chest doi: 10.1378/chest.128.3.1393 – volume: 83 start-page: 381 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0010 article-title: Follow-up study of pulmonary function among COVID-19 survivors 1 year after recovery publication-title: J Infect doi: 10.1016/j.jinf.2021.05.034 – volume: 54 start-page: 581 year: 1999 ident: 10.1016/j.eclinm.2021.101255_bib0019 article-title: Usefulness of the medical research council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease publication-title: Thorax doi: 10.1136/thx.54.7.581 – volume: 4 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0003 article-title: Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge publication-title: JAMA Netw Open doi: 10.1001/jamanetworkopen.2020.36142 – volume: 397 start-page: 220 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0012 article-title: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study publication-title: Lancet doi: 10.1016/S0140-6736(20)32656-8 – volume: 58 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0008 article-title: Diffusion capacity abnormalities for carbon monoxide in patients with COVID-19 at 3-month follow-up publication-title: Eur Respir J doi: 10.1183/13993003.03677-2020 – volume: 76 start-page: 402 year: 2021 ident: 10.1016/j.eclinm.2021.101255_bib0009 article-title: A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations publication-title: Thorax doi: 10.1136/thoraxjnl-2020-216308 – volume: 186 start-page: 132 year: 2012 ident: 10.1016/j.eclinm.2021.101255_bib0024 article-title: Examination of the carbon monoxide diffusing capacity (DL(CO)) in relation to its KCO and VA components publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201112-2160CI – volume: 588 start-page: 315 year: 2020 ident: 10.1016/j.eclinm.2021.101255_bib0029 article-title: Sex differences in immune responses that underlie COVID-19 disease outcomes publication-title: Nature doi: 10.1038/s41586-020-2700-3 – volume: 55 year: 2020 ident: 10.1016/j.eclinm.2021.101255_bib0007 article-title: Abnormal pulmonary function in COVID-19 patients at time of hospital discharge publication-title: Eur Respir J doi: 10.1183/13993003.01217-2020 |
| SSID | ssj0002048960 |
| Score | 2.2705755 |
| Snippet | The dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to describe the... SummaryBackgroundThe dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed... Background: The dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We aimed to... |
| SourceID | doaj pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 101255 |
| SubjectTerms | COVID-19 Dynamic changes Internal Medicine Pulmonary diffusion capacity |
| Title | Dynamic changes of pulmonary diffusion capacity in survivors of non-critical COVID-19 during the first six months |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S2589537021005368 https://www.clinicalkey.es/playcontent/1-s2.0-S2589537021005368 https://dx.doi.org/10.1016/j.eclinm.2021.101255 https://www.ncbi.nlm.nih.gov/pubmed/35018338 https://www.proquest.com/docview/2619211968 https://pubmed.ncbi.nlm.nih.gov/PMC8735830 https://doaj.org/article/2317f89b447e4ac6bf2e983b531a554a |
| Volume | 43 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQD4gL4s3ykpG4Rji248cRWqqCBBygqDfL9tpqqirbbjYI_j1jO1llAWk5cE38SGYmM9_E80DoFWmWLspoqxjA0-FW-8pGFuFzX0YugwKIn6MtPomTU_7hrDmbtfpKMWGlPHAh3GvAHzIq7TjM5NYLF2nQijmQHQumMEMjsHkzZ-oiH69xpXOKMG2UrhomyZQ3l4O7Qso7TInotE6XaMr0m9mlXL5_xzz9CT9_j6KcmaXjO-j2iCfxm_Ied9GN0N1DNz-OJ-b30fVRaTmPS4Zvj1cRXw2XIHx2_ROn9ihD-l-GPRhND4gctx3uB9Af31frPLhbdZUf-yHgw8_f3h9VtcYluxEDesSxBQCJ-_YHhkU35_0DdHr87uvhSTW2Wai8YHJT1VEKJwR4pJyHWmkal5w4Jj1R3PmGRO4c4DweFQnEamaD5Toy6zRzITrJHqIDeJbwGGHmGau9FqERltdUaiK0dSQAE2rHFF0gNhHZ-LEGeWqFcWmmYLMLU1hjEmtMYc0CVdtZV6UGx57xbxP_tmNTBe18AeTKjHJl9snVAjUT982UpApqFRZq92wu_zYv9KNu6E1temqI-ZIkMwkmON2gCYWazxzhT4E1_7Dny0k8DWiHdORju7AaepP94xq0LKz-qIjrliy5liNjad8dQd6h2-6drj3PFciVZI1i5Mn_IPRTdIumlJL8W-sZOtish_AcgN7Gvcjf9C_4QU8X |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dynamic+changes+of+pulmonary+diffusion+capacity+in+survivors+of+non-critical+COVID-19+during+the+first+six+months&rft.jtitle=EClinicalMedicine&rft.au=Mu+Chen&rft.au=Jingwei+Liu&rft.au=Ping+Peng&rft.au=Wenhua+Jian&rft.date=2022-01-01&rft.pub=Elsevier&rft.issn=2589-5370&rft.eissn=2589-5370&rft.volume=43&rft.spage=101255&rft_id=info:doi/10.1016%2Fj.eclinm.2021.101255&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_2317f89b447e4ac6bf2e983b531a554a |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F25895370%2Fcov200h.gif |