CNS Inflammation and Bone Marrow Neuropathy in Type 1 Diabetes

• Published in: The American journal of pathology Vol. 183; no. 5; pp. 1608 - 1620
• Main Authors: Hu, Ping, Thinschmidt, Jeffrey S., Yan, Yuanqing, Hazra, Sugata, Bhatwadekar, Ashay, Caballero, Sergio, Salazar, Tatiana, Miyan, Jaleel A., Li, Wencheng, Derbenev, Andrei, Zsombok, Andrea, Tikhonenko, Maria, Dominguez, James M., McGorray, Susan P., Saban, Daniel R., Boulton, Michael E., Busik, Julia V., Raizada, Mohan K., Chan-Ling, Tailoi, Grant, Maria B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2013; American Society for Investigative Pathology
• Subjects: Animals; Bone Marrow - drug effects; Bone Marrow - innervation; Bone Marrow - pathology; Central Nervous System - drug effects; Central Nervous System - metabolism; Central Nervous System - pathology; Cytokines - metabolism; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - pathology; Enzyme-Linked Immunosorbent Assay; Green Fluorescent Proteins - metabolism; Hematopoiesis - drug effects; Herpesvirus 1, Suid - drug effects; Herpesvirus 1, Suid - physiology; Humans; Inflammation - complications; Inflammation - metabolism; Inflammation - pathology; Intercellular Signaling Peptides and Proteins - metabolism; Male; Mice; Mice, Inbred C57BL; Microglia - drug effects; Microglia - metabolism; Microglia - pathology; Minocycline - pharmacology; Models, Biological; Monocytes - drug effects; Monocytes - metabolism; Monocytes - pathology; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neurotransmitter Agents - metabolism; Pathology; Proto-Oncogene Proteins c-fos - metabolism; Rats; Rats, Wistar; Regular; Sympathetic Nervous System - drug effects; Sympathetic Nervous System - metabolism; Sympathetic Nervous System - pathology

By using pseudorabies virus expressing green fluorescence protein, we found that efferent bone marrow–neural connections trace to sympathetic centers of the central nervous system in normal mice. However, this was markedly reduced in type 1 diabetes, suggesting a significant loss of bone marrow inne...