A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 139; no. 2; p. 653
• Main Authors: Lee, Jung Hoon, Wada, Taira, Febbraio, Maria, He, Jinhan, Matsubara, Tsutomu, Lee, Min Jae, Gonzalez, Frank J, Xie, Wen
• Format: Journal Article
• Language: English
• Published: United States 01.08.2010
• Subjects: Adiposity; Animals; Basic Helix-Loop-Helix Transcription Factors; Body Weight; CD36 Antigens - genetics; CD36 Antigens - metabolism; Cell Line; Fatty Acid Transport Proteins - metabolism; Fatty Acids - metabolism; Fatty Liver - chemically induced; Fatty Liver - genetics; Fatty Liver - metabolism; Fatty Liver - physiopathology; Female; Humans; Liver - drug effects; Liver - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Oxidation-Reduction; Oxidative Stress; Polychlorinated Dibenzodioxins - toxicity; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon - agonists; Receptors, Aryl Hydrocarbon - deficiency; Receptors, Aryl Hydrocarbon - genetics; Receptors, Aryl Hydrocarbon - metabolism; Transfection; Triglycerides - metabolism

The aryl hydrocarbon receptor (AhR) also known as the dioxin receptor or xenobiotic receptor is a member of the basic helix-loop-helix/period AhR nuclear translocator single minded family. The goal of this study was to determine the endobiotic role of AhR in hepatic steatosis. Wild-type, constitutiv...