Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice

• Published in: Biological research Vol. 53; no. 1; pp. 48 - 12
• Main Authors: Gao, Jintao, Chen, Fangru, Fang, Huanan, Mi, Jing, Qi, Qi, Yang, Mengjuan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.10.2020; BioMed Central; Sociedad de Biología de Chile; BMC
• Subjects: Adjuvants, Immunologic - adverse effects; Analysis; Animals; Anti-Inflammatory Agents - pharmacology; Antiviral drugs; Apoptosis; BIOLOGY; Cell growth; Cell Proliferation; Cell viability; Cholecystokinin; Cytokines; Daphnetin; Dermatologic agents; Dermatology; Erythema; Formulae, receipts, prescriptions; Humans; IL-1β; Imiquimod; Imiquimod - adverse effects; Immunofluorescence; Inflammation; Inflammation - drug therapy; Inflammatory response; Interleukin 22; Interleukin 6; Interleukin 8; Keratin; Keratinocytes; Mice; Mice, Inbred BALB C; Monocyte chemoattractant protein 1; mRNA; NF-κB protein; NF-κb signaling pathway; Nuclear nonproliferation; Nuclear transport; Oncostatin M; Pathogenesis; Phosphorylation; Proliferation; Psoriasis; Psoriasis - chemically induced; Psoriasis - drug therapy; Rabbits; RNA; Signal transduction; Skin; Skin diseases; Skin lesions; Tumor necrosis factor; Tumor necrosis factor-α; Umbelliferones - pharmacology; Western blotting; Inflammatory response; Daphnetin; NF-κb signaling pathway; Proliferation; Psoriasis

Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hyperproliferation and excessive inflammatory response are considered to be potentially usefu...