Genetic Variants of LRRK2 in Taiwanese Parkinson’s Disease

• Published in: PloS one Vol. 8; no. 12; p. e82001
• Main Authors: Wu, Yih-Ru, Chang, Kuo-Hsuan, Chang, Wen-Teng, Hsiao, Ya-Chin, Hsu, Hsuan-Chu, Jiang, Pei-Ru, Chen, Yi-Chun, Chao, Chih-Ying, Chang, Yi-Chung, Lee, Bo-Hsun, Hu, Fen-Ju, Chen, Wan-Ling, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 05.12.2013
• Subjects: Age; Amino acids; Bioinformatics; Chromosomes; Confidence intervals; Genetic aspects; Genetic diversity; Genetic variance; Genotyping; Haplotypes; Health risks; Inflammatory bowel disease; Kinases; Leucine; Life sciences; LRRK2 protein; Medicine; Missense mutation; Movement disorders; Mutation; Neurodegenerative diseases; Neurology; Parkinson's disease; Patients; Physicians; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Statistical analysis; Taiwan

Genetic variants of leucine-rich repeat kinase 2 (LRRK2) were reported to alter the risk for Parkinson's disease (PD). However, the genetic spectrum of LRRK2 variants has not been clearly disclosed yet in Taiwanese population. Herein, we sequenced LRRK2 coding region in 70 Taiwanese early onset...