Electropharmacological Characterization of Aciclovir in the Halothane-Anesthetized Dogs: A Proposal of Evaluation Method for Cardiovascular Safety Pharmacology of Anti-virus Drugs

• Published in: Cardiovascular toxicology Vol. 20; no. 4; pp. 419 - 426
• Main Authors: Kondo, Yoshiki, Hagiwara-Nagasawa, Mihoko, Kambayashi, Ryuichi, Goto, Ai, Chiba, Koki, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Matsumoto, Akio, Sugiyama, Atsushi
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2020; Springer; Springer Nature B.V
• Subjects: Action Potentials - drug effects; Acyclovir - toxicity; Analysis; Anesthesia, Inhalation; Anesthetics; Anesthetics, Inhalation; Animals; Antiviral Agents - toxicity; Arrhythmia; Arrhythmias, Cardiac - chemically induced; Arrhythmias, Cardiac - diagnosis; Arrhythmias, Cardiac - physiopathology; Biomedical and Life Sciences; Biomedicine; Blood pressure; Bradycardia; Calcium; Calcium ions; Cardiology; Change detection; Conduction; Contraction; Dogs; Dosage; Dose-Response Relationship, Drug; Drug therapy; Electrocardiography; Female; Frequency dependence; Halothane; Health aspects; Heart; Heart beat; Heart Conduction System - drug effects; Heart Conduction System - physiopathology; Heart rate; Heart Rate - drug effects; Hypertension; Hypotension; Methods; Pain; Pharmacology; Pharmacology/Toxicology; Prolongation; Risk Assessment; Sympathetic nervous system; Tachycardia; Time Factors; Toxicity Tests; Ventricle; Viruses; Aciclovir; inhibition; QT prolongation; Anti-virus drug; Cardiovascular adverse events; IKr inhibition

Given limited information regarding the pathophysiology underlying aciclovir-associated, clinically observed cardiovascular adverse events including chest pain, tachycardia, bradycardia, palpitation, arrhythmia, hypertension and hypotension, we investigated its electropharmacological effects using t...