Gene Expression Noise in Spatial Patterning: hunchback Promoter Structure Affects Noise Amplitude and Distribution in Drosophila Segmentation

• Published in: PLoS computational biology Vol. 7; no. 2; p. e1001069
• Main Authors: Holloway, David M., Lopes, Francisco J. P., da Fontoura Costa, Luciano, Travençolo, Bruno A. N., Golyandina, Nina, Usevich, Konstantin, Spirov, Alexander V.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2011; Public Library of Science (PLoS)
• Subjects: Animals; Animals, Genetically Modified; Binding Sites - genetics; Biophysics/Transcription and Translation; Body Patterning - genetics; Body Patterning - physiology; Computational Biology; Computational Biology/Transcriptional Regulation; Computer Science/Applications; Developmental Biology/Developmental Molecular Mechanisms; Developmental Biology/Pattern Formation; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Drosophila; Drosophila melanogaster - embryology; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Embryonic development; Embryos; Experiments; Gene expression; Gene Expression Profiling - statistics & numerical data; Gene Expression Regulation, Developmental; Genes, Insect; Genetic aspects; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Models, Genetic; Mutation; Noise; Physiological aspects; Promoter Regions, Genetic; Protein Binding; Proteins; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stochastic models; Stochastic Processes; Trans-Activators - genetics; Trans-Activators - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; United States; Genes, Insect; Drosophila Proteins; Promoter Regions, Genetic; Animals, Genetically Modified; Trans-Activators; Computational Biology; Gene Expression Profiling; Animals; Stochastic Processes; Gene Expression Regulation, Developmental; Homeodomain Proteins; Body Patterning; Protein Binding; Models, Genetic; Transcription Factors; Mutation; Binding Sites; Drosophila melanogaster; RNA, Messenger; DNA-Binding Proteins

Positional information in developing embryos is specified by spatial gradients of transcriptional regulators. One of the classic systems for studying this is the activation of the hunchback (hb) gene in early fruit fly (Drosophila) segmentation by the maternally-derived gradient of the Bicoid (Bcd)...