The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer

• Published in: Experimental & molecular medicine Vol. 52; no. 1; pp. 41 - 55
• Main Authors: Xu, Pei, Xiao, Haibo, Yang, Qi, Hu, Rui, Jiang, Lianyong, Bi, Rui, Jiang, Xueyan, Wang, Lei, Mei, Ju, Ding, Fangbao, Huang, Jianbing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2020; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 13/109; 13/51; 13/89; 631/337/458/582; 631/67/1612/1350; 631/80; 64/60; 82/29; 82/51; 82/80; Bioinformatics; Biomedical and Life Sciences; Biomedicine; Cell growth; Cell migration; Cell proliferation; Enzymes; Genomes; Lung cancer; Medical Biochemistry; Molecular Medicine; Non-small cell lung carcinoma; Ribonucleic acid; RNA; Small cell lung carcinoma; Stem Cells; Therapeutic applications; Transcription; Tumorigenesis; 생화학

Deubiquitinases (DUBs) and noncoding RNAs have been the subjects of recent extensive studies regarding their roles in lung cancer, but the mechanisms involved are largely unknown. In our study, we used The Cancer Genome Atlas data set and bioinformatics analyses and identified USP21, a DUB, as a pot...