Anoctamin 1/TMEM16A controls intestinal Cl− secretion induced by carbachol and cholera toxin

• Published in: Experimental & molecular medicine Vol. 51; no. 8; pp. 1 - 14
• Main Authors: Lee, Byeongjun, Hong, Gyu-Sang, Lee, Sung Hoon, Kim, Hyungsup, Kim, Ajung, Hwang, Eun Mi, Kim, Jiyoon, Lee, Min Goo, Yang, Jin-Young, Kweon, Mi-Na, Tse, Chung-Ming, Mark, Donowitz, Oh, Uhtaek
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.08.2019; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 13/1; 13/95; 42/41; 631/443; 64/60; 692/420; 9/74; Animals; Anoctamin-1 - genetics; Anoctamin-1 - physiology; Biomedical and Life Sciences; Biomedicine; Calcium - metabolism; Calcium channels; Calcium chloride; Carbachol; Carbachol - pharmacology; Chloride channels (calcium-gated); Chloride Channels - genetics; Chloride Channels - physiology; Chlorides - metabolism; Cholera; Cholera toxin; Cholera Toxin - pharmacology; Colitis; Colitis - chemically induced; Colitis - genetics; Colitis - metabolism; Colitis - pathology; Colon; Colorectal carcinoma; Cyclic AMP; Dextran; Epithelium; Female; Inflammatory bowel disease; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestine; Intestines - drug effects; Male; Medical Biochemistry; Mice; Mice, Knockout; Molecular Medicine; Secretion; Secretory Pathway - drug effects; Secretory Pathway - genetics; Sodium; Sodium sulfate; Stem Cells; Up-Regulation - drug effects; 생화학

Calcium-activated chloride channels (CaCCs) mediate numerous physiological functions and are best known for the transport of electrolytes and water in epithelia. In the intestine, CaCC currents are considered necessary for the secretion of fluid to protect the intestinal epithelium. Although genetic...