Anti-asthma and antitussive effects of a fermented extract of a mixture of Ramulus mori, Anthriscus sylvestris, and Salvia plebeian

Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia pleb...

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Published in	Food Science and Biotechnology Vol. 30; no. 9; pp. 1257 - 1268
Main Authors	An, Mirae, Oh, Miae, Park, Keun-Tae, Seon, Ki Hwan, Jo, Jeong Eun, Lee, Seong Kweon, Kim, Jeong-Keun, Shin, Kwang Soon, Koh, Jong-Ho, Lim, Young-Hee
Format	Journal Article
Language	English
Published	Singapore Springer Science and Business Media LLC 01.09.2021 Springer Singapore Springer Nature B.V 한국식품과학회
Subjects	Anthriscus sylvestris Arginine Asthma biotechnology blood serum Bronchus Chemistry Chemistry and Materials Science Citric acid dust fermentation Food Science Guinea pigs Hepatotoxicity Herbal medicine immunity Immunoglobulin E Inflammation Interleukin 17 Interleukin 4 Interleukin 8 Lipopolysaccharides lungs Medicinal plants Nutrition Ovalbumin Plant extracts Research Article Respiratory diseases Salvia plebeia 식품과학 Anti-asthma Antitussive Anti-inflammation Fermented extract of medicinal plant
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ISSN	1226-7708 2092-6456 2092-6456
DOI	10.1007/s10068-021-00955-3

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Abstract	Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia , and Anthriscus sylvestris . The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health.
AbstractList	Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia , and Anthriscus sylvestris . The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health. Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing , and . The expression levels of and in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health. The online version contains supplementary material available at 10.1007/s10068-021-00955-3. Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia, and Anthriscus sylvestris. The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health. Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia, and Anthriscus sylvestris. The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health.Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia, and Anthriscus sylvestris. The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health.The online version contains supplementary material available at 10.1007/s10068-021-00955-3.SUPPLEMENTARY INFORMATIONThe online version contains supplementary material available at 10.1007/s10068-021-00955-3. Respiratory immunity is getting more importantrecently due to outbreak of respiratory diseases andincreasing the concentration of fine dust. The aim of thisstudy was to investigate respiratory protection effect of afermented extract of medicinal plants (FEMP) containingRamulus mori, Salvia plebeia, and Anthriscus sylvestris. The expression levels of IL-8 and IL-17 in LPS/poly-Larginine(PLA) and FEMP-cotreated A549 cells were lowerthan those in LPS/PLA only-treated cells. The levels ofIgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid(BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatorycells in the BALF decreased by FEMP treatment. Inthe citric acid-induced coughing guinea pig, the FEMPtreatment decreased the number of coughs. Therefore,FEMP shows anti-asthmatic and antitussive activitieswithout hepatotoxicity and can be used as a compoundaiming to improve respiratory health. KCI Citation Count: 2
Author	Mirae An Miae Oh Keun-Tae Park Seong Kweon Lee Jeong Eun Jo Jeong-Keun Kim Young-Hee Lim Ki Hwan Seon Kwang Soon Shin Jong-Ho Koh
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CitedBy_id	crossref_primary_10_3390_nu14071420 crossref_primary_10_1016_j_phytochem_2023_113865 crossref_primary_10_3390_plants13081087 crossref_primary_10_1007_s10068_024_01521_3
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Snippet	Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this... Respiratory immunity is getting more importantrecently due to outbreak of respiratory diseases andincreasing the concentration of fine dust. The aim of...
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SubjectTerms	Anthriscus sylvestris Arginine Asthma biotechnology blood serum Bronchus Chemistry Chemistry and Materials Science Citric acid dust fermentation Food Science Guinea pigs Hepatotoxicity Herbal medicine immunity Immunoglobulin E Inflammation Interleukin 17 Interleukin 4 Interleukin 8 Lipopolysaccharides lungs Medicinal plants Nutrition Ovalbumin Plant extracts Research Article Respiratory diseases Salvia plebeia 식품과학
Title	Anti-asthma and antitussive effects of a fermented extract of a mixture of Ramulus mori, Anthriscus sylvestris, and Salvia plebeian
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ispartofPNX	Food Science and Biotechnology, 2021, 30(9), , pp.1257-1268
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