Mechanisms regulating intestinal barrier integrity and its pathological implications

• Published in: Experimental & molecular medicine Vol. 50; no. 8; pp. 1 - 9
• Main Authors: Chelakkot, Chaithanya, Ghim, Jaewang, Ryu, Sung Ho
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2018; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 631/80/304; 692/699/1503; 96; 96/95; Animals; Antigens; Bacteria; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cytokines; Dendritic cells; Disease; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - pathology; Gastrointestinal tract; Humans; Immune system; Inflammatory bowel diseases; Intestinal Diseases - pathology; Intestinal Mucosa - pathology; Intestine; Intestines - pathology; Intracellular signalling; Medical Biochemistry; Metabolic disorders; Microbiota; Molecular biology; Molecular Medicine; Mucosa; Peptides; Permeability; Post-translation; Proteins; Regulation; Review; Review Article; Signal transduction; Stem Cells; Tight Junction Proteins - metabolism; 생화학

The gastrointestinal tract is a specialized organ in which dynamic interactions between host cells and the complex environment occur in addition to food digestion. Together with the chemical barrier of the mucosal layer and the cellular immune system, the epithelial cell layer performs a pivotal rol...