Fibroblast growth factors as tissue repair and regeneration therapeutics

• Published in: PeerJ (San Francisco, CA) Vol. 4; p. e1535
• Main Authors: Nunes, Quentin M, Li, Yong, Sun, Changye, Kinnunen, Tarja K, Fernig, David G
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 12.01.2016; PeerJ, Inc; PeerJ Inc
• Subjects: Biochemistry; Biotechnology; Cancer; Cell growth; Cell interactions; Communication; Drugs and Devices; Extracellular matrix; Fibroblast growth factor; Fibroblast growth factor receptor; Fibroblast growth factor receptors; Fibroblast growth factors; Fibroblasts; Growth factors; Heparan sulfate; Homeostasis; Kinases; Klotho; Klotho protein; Ligands; Organogenesis; Paracrine signalling; Physiological aspects; Proteins; Sulfates; Surgery and Surgical Specialties; Therapeutics; Translation; Translational Medicine; Tyrosine; Ulcer; Wound; Heparan sulfate; Fibroblast growth factor; Healing; Ulcer; Klotho; Protein therapeutic; Fibroblast growth factor receptor; Wound; Tissue repair

Cell communication is central to the integration of cell function required for the development and homeostasis of multicellular animals. Proteins are an important currency of cell communication, acting locally (auto-, juxta-, or paracrine) or systemically (endocrine). The fibroblast growth factor (F...