Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges

Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes,...

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Published inTrends in molecular medicine Vol. 16; no. 12; pp. 574 - 583
Main Authors He, Xiaoxiao, Gao, Jinhao, Gambhir, Sanjiv Sam, Cheng, Zhen
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2010
Subjects
Animals
Fluorescent Dyes - adverse effects
Humans
Molecular Imaging - instrumentation
Nanoparticles - adverse effects
Nanotechnology - instrumentation
Neoplasms - diagnosis
Pathology
Spectroscopy, Near-Infrared - instrumentation
Online AccessGet full text
ISSN1471-4914
1471-499X
1471-499X
DOI10.1016/j.molmed.2010.08.006

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Abstract Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity, and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will probably be realized through persistent interdisciplinary amalgamation of diverse research fields.
AbstractList Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity, and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will probably be realized through persistent interdisciplinary amalgamation of diverse research fields.
Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will likely be realized through persistent interdisciplinary amalgamation of diverse research fields.
Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity, and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will probably be realized through persistent interdisciplinary amalgamation of diverse research fields.Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity, and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will probably be realized through persistent interdisciplinary amalgamation of diverse research fields.
Author He, Xiaoxiao
Cheng, Zhen
Gao, Jinhao
Gambhir, Sanjiv Sam
AuthorAffiliation 3 Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China
4 Departments of Radiology and Bioengineering, Stanford University, Stanford, California 94305, USA
1 Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA
2 State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Biology, Hunan University, Changsha 410082, P.R. China
AuthorAffiliation_xml – name: 1 Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA
– name: 3 Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China
– name: 2 State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Biology, Hunan University, Changsha 410082, P.R. China
– name: 4 Departments of Radiology and Bioengineering, Stanford University, Stanford, California 94305, USA
Author_xml – sequence: 1
  givenname: Xiaoxiao
  surname: He
  fullname: He, Xiaoxiao
  organization: Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA
– sequence: 2
  givenname: Jinhao
  surname: Gao
  fullname: Gao, Jinhao
  organization: Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA
– sequence: 3
  givenname: Sanjiv Sam
  surname: Gambhir
  fullname: Gambhir, Sanjiv Sam
  organization: Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA
– sequence: 4
  givenname: Zhen
  surname: Cheng
  fullname: Cheng, Zhen
  email: zcheng@stanford.edu
  organization: Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20870460$$D View this record in MEDLINE/PubMed
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Snippet Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new...
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SubjectTerms Animals
Fluorescent Dyes - adverse effects
Humans
Molecular Imaging - instrumentation
Nanoparticles - adverse effects
Nanotechnology - instrumentation
Neoplasms - diagnosis
Pathology
Spectroscopy, Near-Infrared - instrumentation
Title Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
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