Secretory glycoprotein NS1 plays a crucial role in the particle formation of flaviviruses

• Published in: PLoS pathogens Vol. 18; no. 6; p. e1010593
• Main Authors: Tamura, Tomokazu, Torii, Shiho, Kajiwara, Kentaro, Anzai, Itsuki, Fujioka, Yoichiro, Noda, Kisho, Taguwa, Shuhei, Morioka, Yuhei, Suzuki, Rigel, Fauzyah, Yuzy, Ono, Chikako, Ohba, Yusuke, Okada, Masato, Fukuhara, Takasuke, Matsuura, Yoshiharu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2022; Public Library of Science (PLoS)
• Subjects: Amino acids; Apolipoproteins; Biology and life sciences; Cloning; Dengue fever; Encephalitis; Endoplasmic reticulum; Flaviviridae; Genomes; Glycoproteins; Health risks; Infections; Life cycles; Lipids; Medicine and Health Sciences; Mutagenesis; Mutants; Mutation; Oligomerization; Pathogenesis; Protein interaction; Proteins; Public health; Replication; Research and Analysis Methods; Roles; Viruses; West Nile virus

Flaviviruses, which are globally distributed and cause a spectrum of potentially severe illnesses, pose a major threat to public health. Although Flaviviridae viruses, including flaviviruses, possess similar genome structures, only the flaviviruses encode the non-structural protein NS1, which reside...