Evolution of the gut microbiome following acute HIV-1 infection

• Published in: Microbiome Vol. 7; no. 1; pp. 73 - 17
• Main Authors: Rocafort, Muntsa, Noguera-Julian, Marc, Rivera, Javier, Pastor, Lucía, Guillén, Yolanda, Langhorst, Jost, Parera, Mariona, Mandomando, Inacio, Carrillo, Jorge, Urrea, Víctor, Rodríguez, Cristina, Casadellà, Maria, Calle, Maria Luz, Clotet, Bonaventura, Blanco, Julià, Naniche, Denise, Paredes, Roger
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.05.2019; BioMed Central; BMC
• Subjects: Acute Disease; acute HIV-1 infection; Adenoviruses; Adult; AIDS; Anergy; Antiretroviral agents; Antiretroviral therapy; Antiviral agents; Bacteria - classification; Bacteria - isolation & purification; Bioinformatics; CD4-Positive T-Lymphocytes; CD8 antigen; CD8-Positive T-Lymphocytes; Chronic Disease; Chronic infection; Digestive system; Feces - virology; Female; Gastrointestinal Microbiome; Genes; Genomes; Gut microbiota; HIV; HIV infections; HIV Infections - drug therapy; HIV Infections - microbiology; HIV-1; HIV-1 - isolation & purification; HIV-1 pathogenesis; Human immunodeficiency virus; Humans; Infeccions per VIH; Infections; Inflammation; Intestinal microflora; Lymphocytes; Lymphocytes T; Male; Metabolic disorders; Metagenomics; Microbiome; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Middle Aged; Monkeys & apes; Mozambique; Prospective Studies; Risk factors; Simian immunodeficiency virus; Studies; T cells; Taxonomy; Transcriptome; Type 2 diabetes; Viral Load; Virus diseases; Virus Shedding; Viruses; Young Adult; Mozambique; HIV-1; AIDS; HIV-1 pathogenesis; acute HIV-1 infection; Microbiome

In rhesus macaques, simian immunodeficiency virus infection is followed by expansion of enteric viruses but has a limited impact on the gut bacteriome. To understand the longitudinal effects of HIV-1 infection on the human gut microbiota, we prospectively followed 49 Mozambican subjects diagnosed wi...