Amino acids in cancer
Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer 1 . The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon...
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| Published in | Experimental & molecular medicine Vol. 52; no. 1; pp. 15 - 30 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.01.2020
Springer Nature B.V Nature Publishing Group 생화학분자생물학회 |
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| Online Access | Get full text |
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| Abstract | Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer
1
. The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon metabolism contributions to cancer cell viability and growth. Amino acids, nutrients vital to the survival of all cell types, experience reprogrammed metabolism in cancer. This review outlines the diverse roles of amino acids within the tumor and in the tumor microenvironment. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, amino acid derivatives contribute to epigenetic regulation and immune responses linked to tumorigenesis and metastasis. Furthermore, in discussing the transporters and transaminases that mediate amino acid uptake and synthesis, we identify potential metabolic liabilities as targets for therapeutic intervention.
Cancer: How tumors hijack basic building blocks
Cancer changes how the body uses amino acids, the building blocks that all proteins are made of. A better understanding of these changes could lead to new cancer therapies. Cancer was already known to alter the body’s sugar metabolism to feed extra energy to fast-growing tumors. Recent reports have revealed that cancer also rewires amino acid metabolism. Jiyeon Kim at the University of Illinois at Chicago, USA, and co-workers have reviewed how cancer co-opts amino acids. They report that tumors use amino acids as an energy source and antioxidant precursor to balance their production of toxic reactive oxygen species. Amino acids are also instrumental in annotating the epigenetic code to enhance or suppress expression of tumor-related genes. The review illuminates a promising new approach to cancer therapeutics. |
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| AbstractList | Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer
. The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon metabolism contributions to cancer cell viability and growth. Amino acids, nutrients vital to the survival of all cell types, experience reprogrammed metabolism in cancer. This review outlines the diverse roles of amino acids within the tumor and in the tumor microenvironment. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, amino acid derivatives contribute to epigenetic regulation and immune responses linked to tumorigenesis and metastasis. Furthermore, in discussing the transporters and transaminases that mediate amino acid uptake and synthesis, we identify potential metabolic liabilities as targets for therapeutic intervention. Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer 1 . The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon metabolism contributions to cancer cell viability and growth. Amino acids, nutrients vital to the survival of all cell types, experience reprogrammed metabolism in cancer. This review outlines the diverse roles of amino acids within the tumor and in the tumor microenvironment. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, amino acid derivatives contribute to epigenetic regulation and immune responses linked to tumorigenesis and metastasis. Furthermore, in discussing the transporters and transaminases that mediate amino acid uptake and synthesis, we identify potential metabolic liabilities as targets for therapeutic intervention. Cancer changes how the body uses amino acids, the building blocks that all proteins are made of. A better understanding of these changes could lead to new cancer therapies. Cancer was already known to alter the body’s sugar metabolism to feed extra energy to fast-growing tumors. Recent reports have revealed that cancer also rewires amino acid metabolism. Jiyeon Kim at the University of Illinois at Chicago, USA, and co-workers have reviewed how cancer co-opts amino acids. They report that tumors use amino acids as an energy source and antioxidant precursor to balance their production of toxic reactive oxygen species. Amino acids are also instrumental in annotating the epigenetic code to enhance or suppress expression of tumor-related genes. The review illuminates a promising new approach to cancer therapeutics. Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer1. The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon metabolism contributions to cancer cell viability and growth. Amino acids, nutrients vital to the survival of all cell types, experience reprogrammed metabolism in cancer. This review outlines the diverse roles of amino acids within the tumor and in the tumor microenvironment. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, amino acid derivatives contribute to epigenetic regulation and immune responses linked to tumorigenesis and metastasis. Furthermore, in discussing the transporters and transaminases that mediate amino acid uptake and synthesis, we identify potential metabolic liabilities as targets for therapeutic intervention.Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer1. The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon metabolism contributions to cancer cell viability and growth. Amino acids, nutrients vital to the survival of all cell types, experience reprogrammed metabolism in cancer. This review outlines the diverse roles of amino acids within the tumor and in the tumor microenvironment. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, amino acid derivatives contribute to epigenetic regulation and immune responses linked to tumorigenesis and metastasis. Furthermore, in discussing the transporters and transaminases that mediate amino acid uptake and synthesis, we identify potential metabolic liabilities as targets for therapeutic intervention. Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer1. The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon metabolism contributions to cancer cell viability and growth. Amino acids, nutrients vital to the survival of all cell types, experience reprogrammed metabolism in cancer. This review outlines the diverse roles of amino acids within the tumor and in the tumor microenvironment. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, amino acid derivatives contribute to epigenetic regulation and immune responses linked to tumorigenesis and metastasis. Furthermore, in discussing the transporters and transaminases that mediate amino acid uptake and synthesis, we identify potential metabolic liabilities as targets for therapeutic intervention.Cancer: How tumors hijack basic building blocksCancer changes how the body uses amino acids, the building blocks that all proteins are made of. A better understanding of these changes could lead to new cancer therapies. Cancer was already known to alter the body’s sugar metabolism to feed extra energy to fast-growing tumors. Recent reports have revealed that cancer also rewires amino acid metabolism. Jiyeon Kim at the University of Illinois at Chicago, USA, and co-workers have reviewed how cancer co-opts amino acids. They report that tumors use amino acids as an energy source and antioxidant precursor to balance their production of toxic reactive oxygen species. Amino acids are also instrumental in annotating the epigenetic code to enhance or suppress expression of tumor-related genes. The review illuminates a promising new approach to cancer therapeutics. Cancer: How tumors hijack basic building blocks Cancer changes how the body uses amino acids, the building blocks that all proteins are made of. A better understanding of these changes could lead to new cancer therapies. Cancer was already known to alter the body’s sugar metabolism to feed extra energy to fast-growing tumors. Recent reports have revealed that cancer also rewires amino acid metabolism. Jiyeon Kim at the University of Illinois at Chicago, USA, and co-workers have reviewed how cancer co-opts amino acids. They report that tumors use amino acids as an energy source and antioxidant precursor to balance their production of toxic reactive oxygen species. Amino acids are also instrumental in annotating the epigenetic code to enhance or suppress expression of tumor-related genes. The review illuminates a promising new approach to cancer therapeutics. Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer 1 . The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon metabolism contributions to cancer cell viability and growth. Amino acids, nutrients vital to the survival of all cell types, experience reprogrammed metabolism in cancer. This review outlines the diverse roles of amino acids within the tumor and in the tumor microenvironment. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, amino acid derivatives contribute to epigenetic regulation and immune responses linked to tumorigenesis and metastasis. Furthermore, in discussing the transporters and transaminases that mediate amino acid uptake and synthesis, we identify potential metabolic liabilities as targets for therapeutic intervention. Cancer: How tumors hijack basic building blocks Cancer changes how the body uses amino acids, the building blocks that all proteins are made of. A better understanding of these changes could lead to new cancer therapies. Cancer was already known to alter the body’s sugar metabolism to feed extra energy to fast-growing tumors. Recent reports have revealed that cancer also rewires amino acid metabolism. Jiyeon Kim at the University of Illinois at Chicago, USA, and co-workers have reviewed how cancer co-opts amino acids. They report that tumors use amino acids as an energy source and antioxidant precursor to balance their production of toxic reactive oxygen species. Amino acids are also instrumental in annotating the epigenetic code to enhance or suppress expression of tumor-related genes. The review illuminates a promising new approach to cancer therapeutics. Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer1. The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon metabolism contributions to cancer cell viability and growth. Amino acids, nutrients vital to the survival of all cell types, experience reprogrammed metabolism in cancer. This review outlines the diverse roles of amino acids within the tumor and in the tumor microenvironment. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, amino acid derivatives contribute to epigenetic regulation and immune responses linked to tumorigenesis and metastasis. Furthermore, in discussing the transporters and transaminases that mediate amino acid uptake and synthesis, we identify potential metabolic liabilities as targets for therapeutic intervention. KCI Citation Count: 0 Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer 1 . The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon metabolism contributions to cancer cell viability and growth. Amino acids, nutrients vital to the survival of all cell types, experience reprogrammed metabolism in cancer. This review outlines the diverse roles of amino acids within the tumor and in the tumor microenvironment. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, amino acid derivatives contribute to epigenetic regulation and immune responses linked to tumorigenesis and metastasis. Furthermore, in discussing the transporters and transaminases that mediate amino acid uptake and synthesis, we identify potential metabolic liabilities as targets for therapeutic intervention. |
| Author | Rhyne, Shawn Kim, Jiyeon Lieu, Elizabeth L. Nguyen, Tu |
| Author_xml | – sequence: 1 givenname: Elizabeth L. surname: Lieu fullname: Lieu, Elizabeth L. organization: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago – sequence: 2 givenname: Tu surname: Nguyen fullname: Nguyen, Tu organization: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago – sequence: 3 givenname: Shawn surname: Rhyne fullname: Rhyne, Shawn organization: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago – sequence: 4 givenname: Jiyeon surname: Kim fullname: Kim, Jiyeon email: jiyeonk@uic.edu organization: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31980738$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002555939$$DAccess content in National Research Foundation of Korea (NRF) |
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| Snippet | Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing... Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing... Cancer: How tumors hijack basic building blocks Cancer changes how the body uses amino acids, the building blocks that all proteins are made of. A better... Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics... |
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| SubjectTerms | 631/67/2327 631/80 Amino acids Amino Acids - metabolism Animals Antioxidants Biomedical and Life Sciences Biomedicine Cancer Cell survival Cell viability Citric acid Energy metabolism Epigenesis, Genetic - physiology Epigenetics Glycolysis Humans Immune response Medical Biochemistry Metabolism Metastases Molecular Medicine Neoplasms - metabolism Nutrients Pentose phosphate pathway Reactive oxygen species Review Review Article Stem Cells Tricarboxylic acid cycle Tumor Microenvironment - physiology Tumorigenesis Tumors 생화학 |
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| Title | Amino acids in cancer |
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