Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 141; no. 5; pp. 1572 - 1585
• Main Authors: Gao, Bin, Bataller, Ramon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2011
• Subjects: Adaptive Immunity; Adrenal Cortex Hormones - therapeutic use; Alcohol Drinking - adverse effects; Alcohol Liver Disease; Cytokines; Gastroenterology and Hepatology; Humans; Inflammation; Innate Immunity; Liver Diseases, Alcoholic - etiology; Liver Diseases, Alcoholic - physiopathology; Liver Diseases, Alcoholic - therapy; Liver Transplantation; Nutritional Support; Oxidative Stress - physiology; Temperance; Adaptive Immunity; SAMe; ACC; IL; Cytokines; Innate Immunity; AH; STAT3; Inflammation; SREBP-1c; TNF; LPS; IFN; PPAR; ALD; AMPK; HSC; miRNA; Alcohol Liver Disease; TLR; CB; acetyl-CoA carboxylase; AMP-activated protein kinase; cannabinoid receptor; S-adenosylmethionine; sterol regulatory element-binding protein 1c; hepatic stellate cell; peroxisome proliferator-activated receptor; interleukin; Toll-like receptor; signal transducer and activator of transcription 3; interferon; alcoholic hepatitis; alcoholic liver disease; tumor necrosis factor; microRNA; lipopolysaccharide

Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide and can lead to fibrosis and cirrhosis. The latest surveillance report published by the National Institute on Alcohol Abuse and Alcoholism showed that liver cirrhosis was the 12th leading cause of death in the United S...