Mitochondrial dysfunction and oxidative stress in heart disease

• Published in: Experimental & molecular medicine Vol. 51; no. 12; pp. 1 - 13
• Main Authors: Peoples, Jessica N., Saraf, Anita, Ghazal, Nasab, Pham, Tyler T., Kwong, Jennifer Q.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2019; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 692/699/75; 692/699/75/74; 96; 96/95; Animal models; Animals; Antioxidants; Biomedical and Life Sciences; Biomedicine; Cardiomyopathies - metabolism; Cell fate; Coronary artery disease; Heart diseases; Heart Diseases - metabolism; Humans; Medical Biochemistry; Mitochondria; Mitochondria - metabolism; Mitochondrial Diseases - metabolism; Molecular Medicine; Oxidative stress; Oxidative Stress - physiology; Reactive oxygen species; Reactive Oxygen Species - metabolism; Review; Review Article; Signal Transduction; Stem Cells; 생화학

Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players in molecular signaling and cell fate determination through reactive oxygen species (ROS). While ROS production has historically been portrayed as an unregulated process driving oxidative stress and disease path...