Cellular Plasticity of Inflammatory Myeloid Cells in the Peritoneal Foreign Body Response

• Published in: The American journal of pathology Vol. 176; no. 1; pp. 369 - 380
• Main Authors: Mooney, Jane E, Rolfe, Barbara E, Osborne, Geoffrey W, Sester, David P, van Rooijen, Nico, Campbell, Gordon R, Hume, David A, Campbell, Julie H
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 2010; ASIP; American Society for Investigative Pathology
• Subjects: Animals; Biological and medical sciences; Cell Movement; Cell Shape; Cell Transdifferentiation; Female; Fibroblasts - cytology; Foreign Bodies - pathology; Foreign-Body Reaction - pathology; Green Fluorescent Proteins - metabolism; Implants, Experimental; Investigative techniques, diagnostic techniques (general aspects); Macrophages - cytology; Male; Medical sciences; Mice; Myeloid Cells - pathology; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Peritoneal Cavity - pathology; Peritoneal Lavage; Regular; Anatomic pathology; Plasticity; Foreign body; Inflammation; Inflammatory cell; Myeloid cell; Peritoneum

Implantation of sterile foreign objects in the peritoneal cavity of an animal initiates an inflammatory response and results in encapsulation of the objects by bone marrow-derived cells. Over time, a multilayered tissue capsule develops with abundant myofibroblasts embedded in extracellular matrix....