An integrative systems genetic analysis of mammalian lipid metabolism

• Published in: Nature (London) Vol. 567; no. 7747; pp. 187 - 193
• Main Authors: Parker, Benjamin L., Calkin, Anna C., Seldin, Marcus M., Keating, Michael F., Tarling, Elizabeth J., Yang, Pengyi, Moody, Sarah C., Liu, Yingying, Zerenturk, Eser J., Needham, Elise J., Miller, Matthew L., Clifford, Bethan L., Morand, Pauline, Watt, Matthew J., Meex, Ruth C. R., Peng, Kang-Yu, Lee, Richard, Jayawardana, Kaushala, Pan, Calvin, Mellett, Natalie A., Weir, Jacquelyn M., Lazarus, Ross, Lusis, Aldons J., Meikle, Peter J., James, David E., de Aguiar Vallim, Thomas Q., Drew, Brian G.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2019; Nature Publishing Group
• Subjects: 13/109; 38/89; 45/43; 631/443/319; 631/553; 64/60; 82/58; 82/79; Animals; Bioinformatics; Biological markers; Biomarkers; Blood proteins; Chemical compounds; Cholesterol; Datasets; Diagnostic systems; Fatty liver; Genetic analysis; Genetic aspects; Genetic diversity; Genetic research; Genetic testing; Genetic variance; Genomes; Genomics; HEK293 Cells; Homeostasis; Humanities and Social Sciences; Humans; Identification; Lipid metabolism; Lipid Metabolism - genetics; Lipid Metabolism - physiology; Lipids; Lipids - analysis; Lipids - blood; Lipids - classification; Lipids - genetics; Liver; Liver - chemistry; Liver - metabolism; Liver - pathology; Localization; Male; Mammals; Medical schools; Metabolic disorders; Metabolic syndrome; Metabolism; Methods; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; multidisciplinary; Musculoskeletal system; Obesity - genetics; Obesity - metabolism; Pathogenesis; Peptides; Pharmacology; Physiological aspects; Plasma; Proteasome Endopeptidase Complex - chemistry; Proteasome Endopeptidase Complex - genetics; Proteasome Endopeptidase Complex - metabolism; Proteins; Proteomics; Science; Science (multidisciplinary); Software

Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and progression of hepatosteatosis and metabolic syndrome. These conditions are highly prevalent in developed societies and currently have limited options for diagnostic and therapeutic intervention. Here, using a proteo...