Age‐associated expression of p21and p53 during human wound healing

• Published in: Aging cell Vol. 20; no. 5; pp. e13354 - n/a
• Main Authors: Chia, Chee W., Sherman‐Baust, Cheryl A., Larson, Sara A., Pandey, Ritu, Withers, Roxanne, Karikkineth, Ajoy C., Zukley, Linda M., Campisi, Judith, Egan, Josephine M., Sen, Ranjan, Ferrucci, Luigi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2021; Anatomical Society - Wiley; John Wiley and Sons Inc
• Subjects: Adult; Age; Aged; aging; Aging - metabolism; BASIC BIOLOGICAL SCIENCES; Biomarkers; Biopsy; Care and treatment; Conflicts of interest; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Cyclin-dependent kinase inhibitor p21; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Dipeptidyl-peptidase IV; Female; Fibroblasts; Gelatinase B; human wound healing; Humans; Immunohistochemistry; Male; Metalloproteinase; Older people; p21; p53; Peptidase; Phenotypes; Pilot Projects; Proteins; RNA; Senescence; Short Take; Skin - metabolism; Tumor proteins; Tumor Suppressor Protein p53 - metabolism; Women; Wound Healing; Wounds and injuries; β-Galactosidase; aging; human wound healing; p21; p53

In mice, cellular senescence and senescence‐associated secretory phenotype (SASP) positively contribute to cutaneous wound healing. In this proof‐of‐concept study, we investigated the expressions of p16, p21, and other senescence‐associated biomarkers during human wound healing in 24 healthy subject...