Cardiomyocyte‐derived exosomal microRNA‐92a mediates post‐ischemic myofibroblast activation both in vitro and ex vivo

• Published in: ESC Heart Failure Vol. 7; no. 1; pp. 284 - 288
• Main Authors: Wang, Xujun, Morelli, Marco Bruno, Matarese, Alessandro, Sardu, Celestino, Santulli, Gaetano
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2020; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Apoptosis; Cardiomyocytes; Cell Differentiation; Cells, Cultured; Collagen; Disease Models, Animal; Epigenetics; Exosomes; Exosomes - metabolism; Experiments; Fibroblasts; Heart attacks; Mice; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Myocardial Infarction - genetics; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Myofibroblast; Myofibroblasts - metabolism; Myofibroblasts - pathology; Original; Original s; Pathophysiology; Up-Regulation; Epigenetics; MicroRNA; Exosomes; Myofibroblast

Aims We hypothesize that specific microRNAs (miRNAs) within cardiomyocyte‐derived exosomes play a pivotal role in the phenoconversion of cardiac myofibroblasts following myocardial infarction (MI). Methods and results We used an established murine model of MI, obtained in vivo via ligation of the le...