Endothelial Function and Aminothiol Biomarkers of Oxidative Stress in Healthy Adults

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 52; no. 1; pp. 80 - 85
• Main Authors: Ashfaq, Salman, Abramson, Jerome L., Jones, Dean P., Rhodes, Steven D., Weintraub, William S., Hooper, W Craig, Vaccarino, Viola, Alexander, R Wayne, Harrison, David G., Quyyumi, Arshed A.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.07.2008; Hagerstown, MD Lippincott
• Subjects: Adult; Aged; Arterial hypertension. Arterial hypotension; Atherosclerosis - blood; Atherosclerosis - diagnosis; Atherosclerosis - physiopathology; Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Brachial Artery - diagnostic imaging; Brachial Artery - drug effects; Brachial Artery - physiopathology; Cardiology. Vascular system; Cysteine - analogs & derivatives; Cysteine - blood; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Fundamental and applied biological sciences. Psychology; Glutathione - analogs & derivatives; Glutathione - blood; Glutathione Disulfide - blood; Hemodynamics. Rheology; Humans; Male; Medical sciences; Middle Aged; Nitroglycerin - pharmacology; Oxidative Stress; Risk Factors; Sulfhydryl Compounds - blood; Ultrasonography; Vasodilation; Vertebrates: cardiovascular system; Hypertension; endothelial function; Oxidative stress; risk factors; antioxidants; flow mediated vasodilation; Risk factor; Cardiovascular disease; Antioxidant; Vasodilation

Endothelial dysfunction is known to precede the development of atherosclerosis and results primarily from increased oxidative degradation of NO. We hypothesized that assessment of oxidative stress in the bloodstream will reliably predict endothelial function in healthy adults. A total of 124 healthy...