41-LB: Changes in Circulating Metabolites, Including Butyrate, Points to Underlying Mechanism of a Probiotic Intervention That Improves Postprandial Hyperglycemia in Subjects with Type 2 Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 70; no. Supplement_1
• Main Authors: MCMURDIE, PAUL, STOEVA, MAGDALENA K., NEMCHEK, MADELEINE, TYAGI, SURABHI, GINES, JESSICA, EID, JOHN, KOLTERMAN, ORVILLE G.
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2021
• Subjects: Acetic acid; Animal models; Bile acids; Bilirubin; Biodegradation; Chenodeoxycholic acid; Diabetes; Diabetes mellitus (non-insulin dependent); Fatty acids; Feces; Hyperglycemia; Metabolic disorders; Metabolites; Microbiomes; Oxidation; Placebos; Probiotics; Propionic acid; Sulfonylurea; Ursodeoxycholic acid

Studies in type 2 diabetes (T2D) rodent models suggest the potential for individual microbial taxa in the human gut to improve or worsen metabolic disease via specific metabolites (signals) in hepatic or general circulation. We previously reported significant improvement in postprandial glucose cont...