Constitutive Expression of Adiponectin in Endothelial Progenitor Cells Protects a Rat Model of Cerebral Ischemia

Endothelial progenitor cells (EPCs), as precursors to endothelial cells, play a significant part in the process of endogenous blood vessel repair and maintenance of endothelial integrity. Adiponectin (APN) is an adipocyte-specific adipocytokine. In this study, we aim to test whether we transplant a...

Full description

Saved in:
Bibliographic Details
Published inJournal of neural transplantation & plasticity Vol. 2017; no. 2017; pp. 1 - 8
Main Authors Liu, Yumin, Wang, Meiyao, Feng, Hongliang, Yu, Qing, Xie, Xiaorui, Zhang, Renwei, Li, Yan
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects
Antibodies
Bone marrow
Carotid arteries
Cerebral ischemia
Endothelium
Experiments
Ischemia
Laboratory animals
Peptide hormones
Physiological aspects
Proteins
Stroke
Veins & arteries
China
Online AccessGet full text

Cover

Abstract Endothelial progenitor cells (EPCs), as precursors to endothelial cells, play a significant part in the process of endogenous blood vessel repair and maintenance of endothelial integrity. Adiponectin (APN) is an adipocyte-specific adipocytokine. In this study, we aim to test whether we transplant a combined graft of EPCs transfected with the adiponectin gene into a rat model of cerebral ischemia could improve functional recovery after middle cerebral artery occlusion (MCAO). Sprague-Dawley (SD) rats were randomly divided into a MCAO control group, a MCAO EPC treatment group, and a MCAO LV-APN-EPC treatment group. A focal cerebral ischemia and reperfusion model was induced by the intraluminal suture method. After 2 h of reperfusion, EPCs were transplanted by injection through the tail vein. A rotarod test was conducted to assess behavioral function before MCAO and on days 1, 7, and 14 after MCAO. After 14 d, TTC staining, CD31 immunofluorescence, and TUNEL staining were used to evaluate infarct volume, microvessel density, and cell apoptosis. Results revealed that behavioral function, infarct area percentage, microvessel density, and cell apoptosis rates were more favorable in the LV-APN-EPC treatment group than in the EPC treatment group. These data suggested that gene-modified cell therapy may be a useful approach for the treatment of ischemic stroke.
AbstractList Endothelial progenitor cells (EPCs), as precursors to endothelial cells, play a significant part in the process of endogenous blood vessel repair and maintenance of endothelial integrity. Adiponectin (APN) is an adipocyte-specific adipocytokine. In this study, we aim to test whether we transplant a combined graft of EPCs transfected with the adiponectin gene into a rat model of cerebral ischemia could improve functional recovery after middle cerebral artery occlusion (MCAO). Sprague-Dawley (SD) rats were randomly divided into a MCAO control group, a MCAO EPC treatment group, and a MCAO LV-APN-EPC treatment group. A focal cerebral ischemia and reperfusion model was induced by the intraluminal suture method. After 2 h of reperfusion, EPCs were transplanted by injection through the tail vein. A rotarod test was conducted to assess behavioral function before MCAO and on days 1, 7, and 14 after MCAO. After 14 d, TTC staining, CD31 immunofluorescence, and TUNEL staining were used to evaluate infarct volume, microvessel density, and cell apoptosis. Results revealed that behavioral function, infarct area percentage, microvessel density, and cell apoptosis rates were more favorable in the LV-APN-EPC treatment group than in the EPC treatment group. These data suggested that gene-modified cell therapy may be a useful approach for the treatment of ischemic stroke.
Endothelial progenitor cells (EPCs), as precursors to endothelial cells, play a significant part in the process of endogenous blood vessel repair and maintenance of endothelial integrity. Adiponectin (APN) is an adipocyte-specific adipocytokine. In this study, we aim to test whether we transplant a combined graft of EPCs transfected with the adiponectin gene into a rat model of cerebral ischemia could improve functional recovery after middle cerebral artery occlusion (MCAO). Sprague-Dawley (SD) rats were randomly divided into a MCAO control group, a MCAO EPC treatment group, and a MCAO LV-APN-EPC treatment group. A focal cerebral ischemia and reperfusion model was induced by the intraluminal suture method. After 2 h of reperfusion, EPCs were transplanted by injection through the tail vein. A rotarod test was conducted to assess behavioral function before MCAO and on days 1, 7, and 14 after MCAO. After 14 d, TTC staining, CD31 immunofluorescence, and TUNEL staining were used to evaluate infarct volume, microvessel density, and cell apoptosis. Results revealed that behavioral function, infarct area percentage, microvessel density, and cell apoptosis rates were more favorable in the LV-APN-EPC treatment group than in the EPC treatment group. These data suggested that gene-modified cell therapy may be a useful approach for the treatment of ischemic stroke.Endothelial progenitor cells (EPCs), as precursors to endothelial cells, play a significant part in the process of endogenous blood vessel repair and maintenance of endothelial integrity. Adiponectin (APN) is an adipocyte-specific adipocytokine. In this study, we aim to test whether we transplant a combined graft of EPCs transfected with the adiponectin gene into a rat model of cerebral ischemia could improve functional recovery after middle cerebral artery occlusion (MCAO). Sprague-Dawley (SD) rats were randomly divided into a MCAO control group, a MCAO EPC treatment group, and a MCAO LV-APN-EPC treatment group. A focal cerebral ischemia and reperfusion model was induced by the intraluminal suture method. After 2 h of reperfusion, EPCs were transplanted by injection through the tail vein. A rotarod test was conducted to assess behavioral function before MCAO and on days 1, 7, and 14 after MCAO. After 14 d, TTC staining, CD31 immunofluorescence, and TUNEL staining were used to evaluate infarct volume, microvessel density, and cell apoptosis. Results revealed that behavioral function, infarct area percentage, microvessel density, and cell apoptosis rates were more favorable in the LV-APN-EPC treatment group than in the EPC treatment group. These data suggested that gene-modified cell therapy may be a useful approach for the treatment of ischemic stroke.
Audience Academic
Author Yu, Qing
Wang, Meiyao
Xie, Xiaorui
Zhang, Renwei
Li, Yan
Liu, Yumin
Feng, Hongliang
AuthorAffiliation 2 Department of Neurology, Xiangyang Central Hospital, Xiangyang 441000, China
1 Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
AuthorAffiliation_xml – name: 2 Department of Neurology, Xiangyang Central Hospital, Xiangyang 441000, China
– name: 1 Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
Author_xml – sequence: 1
  fullname: Liu, Yumin
– sequence: 2
  fullname: Wang, Meiyao
– sequence: 3
  fullname: Feng, Hongliang
– sequence: 4
  fullname: Yu, Qing
– sequence: 5
  fullname: Xie, Xiaorui
– sequence: 6
  fullname: Zhang, Renwei
– sequence: 7
  fullname: Li, Yan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29201467$$D View this record in MEDLINE/PubMed
BookMark eNqFkt1rFDEUxQep2G31zWcZEETQbZNMPmZehLKsWqgoos8hk9zsZplN1iRb9b83425ttyiSgcCd3zm5uTkn1ZEPHqrqKUZnGDN2ThAW57xFnaDsQTXBvBVTRmlzVE0I6tCUdYgeVycprRCinDH2qDomXVFRLibVZhZ8yi5vs7uGev5jEyElF3wdbH1h3KacpbPzdfnm3oS8hMGpof4UwwK8yyHWMxiGNBZyIVOt6s8q1x-CgWH0mEGEPhbFZdJLWDv1uHpo1ZDgyX4_rb6-nX-ZvZ9efXx3Obu4mmresDy1mBva8d4A660hxihBrdEdtkq1PekEsWARZ6SlDEBoUEJ10PZGi8aCMs1pdbnzNUGt5Ca6tYo_ZVBO_i6EuJAqZqcHkAQwJohCD72i1PYKW4MNdA3rSW8aUbze7Lw2234NRoPP5UoHpod_vFvKRbiWjAssKCoGL_cGMXzbQspy7ZIug1MewjZJ3IkGEYpbVtDn99BV2EZfRiUJRYJz3AhySy1UuYDzNpRz9WgqLxjlbdMRPvZ99heqLFNeQpenta7UDwQv7giWoIa8TGEo4SgpOQSf3Z3In1HcBKsAZAfoGFKKYKV2WY0-pQU3SIzkmF45plfu01tEr--Jbnz_gb_a4Uvnjfru_kfvW4bCgFW3NO4aXFr-BSaiBwA
CitedBy_id crossref_primary_10_1152_ajpcell_00200_2018
crossref_primary_10_2174_1574888X15666200331135227
crossref_primary_10_3390_biomedicines10102616
crossref_primary_10_1155_2020_1273198
crossref_primary_10_3389_fneur_2021_630681
crossref_primary_10_31744_einstein_journal_2020RW5160
Cites_doi 10.2337/db16-er10b
10.1126/science.275.5302.964
10.1016/j.jneumeth.2008.06.018
10.1016/s0022-510x(00)00268-9
10.1371/journal.pone.0136819
10.1161/STR.0000000000000024
10.1371/journal.pone.0050105
10.1038/ajh.2008.278
10.1016/j.pneurobio.2007.08.001
10.1016/j.febslet.2009.07.011
10.1038/7434
10.1161/01.cir.103.5.634
10.1038/jcbfm.1990.47
10.1074/jbc.270.45.26746
10.1161/01.HYP.0000168923.92885.f7
10.2337/diabetes.53.1.195
10.2174/138161212799859657
10.1002/stem.219
10.1016/j.jvs.2009.05.049
10.1161/hh0302.104460
10.1038/386671a0
10.1161/01.RES.0000268193.46418.d1
10.1016/j.yjmcc.2011.03.008
10.1056/NEJMoa070240
10.1161/01.cir.0000039526.42991.93
10.12659/MSM.892299
10.1056/nejmc060685
10.1002/ana.21919
10.1074/jbc.M310389200
10.1161/01.str.20.1.84
ContentType Journal Article
Copyright Copyright © 2017 Renwei Zhang et al.
COPYRIGHT 2017 John Wiley & Sons, Inc.
Copyright © 2017 Renwei Zhang et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright © 2017 Renwei Zhang et al. 2017
Copyright_xml – notice: Copyright © 2017 Renwei Zhang et al.
– notice: COPYRIGHT 2017 John Wiley & Sons, Inc.
– notice: Copyright © 2017 Renwei Zhang et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Copyright © 2017 Renwei Zhang et al. 2017
DBID ADJCN
AHFXO
RHU
RHW
RHX
AAYXX
CITATION
NPM
3V.
7X7
7XB
88G
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
K9.
M0S
M2M
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
PSYQQ
Q9U
7X8
5PM
DOA
DOI 10.1155/2017/6809745
DatabaseName الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals
معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete
Hindawi Publishing Complete
Hindawi Publishing Subscription Journals
Hindawi Publishing Open Access
CrossRef
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Psychology Database (Alumni)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Psychology Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest One Psychology
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest One Psychology
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Central (New)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Psychology Journals (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Psychology Journals
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

Publicly Available Content Database
PubMed

CrossRef

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: RHX
  name: Hindawi Publishing Open Access
  url: http://www.hindawi.com/journals/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1687-5443
Editor Wyss, J. Michael
Editor_xml – sequence: 1
  givenname: J. Michael
  surname: Wyss
  fullname: Wyss, J. Michael
EndPage 8
ExternalDocumentID oai_doaj_org_article_2e11204ebeba44fba1fd1de935b2bd37
PMC5671740
A546839267
29201467
10_1155_2017_6809745
1193167
Genre Journal Article
GeographicLocations China
GeographicLocations_xml – name: China
GrantInformation_xml – fundername: National Natural Science Foundation of China
  grantid: 81371273
GroupedDBID ---
123
188
24P
29N
2UF
2WC
4.4
53G
5VS
7X7
8FI
8FJ
AAFWJ
AAJEY
ABDBF
ABIVO
ABUWG
ADBBV
ADJCN
ADRAZ
AEGXH
AENEX
AFKRA
AFPKN
AHFXO
AINHJ
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
CCPQU
CEFSP
CNMHZ
CS3
DIK
DU5
DWQXO
E3Z
EBD
EBS
EJD
EMOBN
ESX
F5P
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
H13
HMCUK
HYE
IAO
IHR
IHW
IL9
INH
INR
IPNFZ
IPY
ITC
KQ8
M2M
M48
M~E
O5R
O5S
OK1
P6G
PGMZT
PIMPY
PSYQQ
RHU
RHX
RIG
RNS
RPM
SV3
TR2
TUS
UKHRP
UZ5
WOQ
WOW
~8M
RHW
0R~
AAYXX
ACCMX
ACUHS
CITATION
OVT
PHGZM
PHGZT
NPM
3V.
7XB
8FK
AAMMB
AEFGJ
AGXDD
AIDQK
AIDYY
K9.
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c635t-f16d496bde5bfd2dda74fdc91faa8b2972fef0652845ee7cea7a9e8bdc73fead3
IEDL.DBID 7X7
ISSN 2090-5904
0792-8483
1687-5443
IngestDate Wed Aug 27 00:51:19 EDT 2025
Thu Aug 21 14:05:52 EDT 2025
Fri Jul 11 15:58:40 EDT 2025
Fri Jul 25 20:53:52 EDT 2025
Wed Mar 19 02:07:01 EDT 2025
Sat Mar 08 18:51:05 EST 2025
Thu May 22 21:27:24 EDT 2025
Wed Feb 19 02:44:04 EST 2025
Tue Jul 01 04:16:33 EDT 2025
Thu Apr 24 23:03:27 EDT 2025
Sun Jun 02 18:48:24 EDT 2024
Tue Nov 26 17:10:07 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2017
Language English
License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c635t-f16d496bde5bfd2dda74fdc91faa8b2972fef0652845ee7cea7a9e8bdc73fead3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Academic Editor: J. Michael Wyss
ORCID 0000-0003-3291-7780
0000-0003-0041-9322
0000-0002-9343-5278
0000-0001-5844-2811
0000-0002-9489-4601
0000-0002-6446-4731
0000-0002-8746-4865
OpenAccessLink https://www.proquest.com/docview/2407661372?pq-origsite=%requestingapplication%
PMID 29201467
PQID 2407661372
PQPubID 4727250
PageCount 8
ParticipantIDs doaj_primary_oai_doaj_org_article_2e11204ebeba44fba1fd1de935b2bd37
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5671740
proquest_miscellaneous_1973024185
proquest_journals_2407661372
gale_infotracmisc_A546839267
gale_infotracacademiconefile_A546839267
gale_healthsolutions_A546839267
pubmed_primary_29201467
crossref_citationtrail_10_1155_2017_6809745
crossref_primary_10_1155_2017_6809745
hindawi_primary_10_1155_2017_6809745
emarefa_primary_1193167
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2017-01-01
PublicationDateYYYYMMDD 2017-01-01
PublicationDate_xml – month: 01
  year: 2017
  text: 2017-01-01
  day: 01
PublicationDecade 2010
PublicationPlace Cairo, Egypt
PublicationPlace_xml – name: Cairo, Egypt
– name: United States
– name: New York
PublicationTitle Journal of neural transplantation & plasticity
PublicationTitleAlternate Neural Plast
PublicationYear 2017
Publisher Hindawi Publishing Corporation
Hindawi
John Wiley & Sons, Inc
Wiley
Publisher_xml – name: Hindawi Publishing Corporation
– name: Hindawi
– name: John Wiley & Sons, Inc
– name: Wiley
References 22
23
24
25
26
27
28
29
30
10
11
12
13
14
15
16
17
18
19
1
2
3
4
5
6
7
8
9
20
21
References_xml – ident: 12
  doi: 10.2337/db16-er10b
– ident: 4
  doi: 10.1126/science.275.5302.964
– ident: 14
  doi: 10.1016/j.jneumeth.2008.06.018
– ident: 15
  doi: 10.1016/s0022-510x(00)00268-9
– ident: 26
  doi: 10.1371/journal.pone.0136819
– ident: 1
  doi: 10.1161/STR.0000000000000024
– ident: 29
  doi: 10.1371/journal.pone.0050105
– ident: 22
  doi: 10.1038/ajh.2008.278
– ident: 17
  doi: 10.1016/j.pneurobio.2007.08.001
– ident: 27
  doi: 10.1016/j.febslet.2009.07.011
– ident: 5
  doi: 10.1038/7434
– ident: 21
  doi: 10.1161/01.cir.103.5.634
– ident: 16
  doi: 10.1038/jcbfm.1990.47
– ident: 9
  doi: 10.1074/jbc.270.45.26746
– ident: 24
  doi: 10.1161/01.HYP.0000168923.92885.f7
– ident: 6
  doi: 10.2337/diabetes.53.1.195
– ident: 8
  doi: 10.2174/138161212799859657
– ident: 11
  doi: 10.1002/stem.219
– ident: 30
  doi: 10.1016/j.jvs.2009.05.049
– ident: 19
  doi: 10.1161/hh0302.104460
– ident: 18
  doi: 10.1038/386671a0
– ident: 23
  doi: 10.1161/01.RES.0000268193.46418.d1
– ident: 28
  doi: 10.1016/j.yjmcc.2011.03.008
– ident: 2
  doi: 10.1056/NEJMoa070240
– ident: 7
  doi: 10.1161/01.cir.0000039526.42991.93
– ident: 25
  doi: 10.12659/MSM.892299
– ident: 3
  doi: 10.1056/nejmc060685
– ident: 20
  doi: 10.1002/ana.21919
– ident: 10
  doi: 10.1074/jbc.M310389200
– ident: 13
  doi: 10.1161/01.str.20.1.84
SSID ssj0046555
ssj0055125
Score 2.5401783
Snippet Endothelial progenitor cells (EPCs), as precursors to endothelial cells, play a significant part in the process of endogenous blood vessel repair and...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
hindawi
emarefa
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1
SubjectTerms Antibodies
Bone marrow
Carotid arteries
Cerebral ischemia
Endothelium
Experiments
Ischemia
Laboratory animals
Peptide hormones
Physiological aspects
Proteins
Stroke
Veins & arteries
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1ba9swFBajMNjL2NZd3GWbBt32MEx90cV-TENKu4cxxgp9E5Il0YDrhCRl27_fObLi1WWjL4W8xDpEkfT5nO_Y50LIYY1puUAU0sxwnrLK2rQSukzBuFjNi8yJvtrnV3F6zr5c8Isbrb4wJqwvD9xv3FHhgBFkDOYymjFvdO5tbl1dclMYW4Y8crB5O2eq18FYFAyDF2EkS3mdsV3IO-fg7efySFQZEGk-MkahZn9IzNXwXQ86-uElesc_F__ioLdDKW_YppMn5HEklXTaL-YpeeC6Z2R_2oFDffWbfqQhzDM8P98nK2zRGeIDQM_R-a8YCNvRpadTu1gtO1SBHYXPvLOYn9UCROm39RKgBrf_ms5c227wAr5_2FBNv-stxZ5qLf7GzK3xXXRLz8BvdlcL_Zycn8x_zE7T2HYhbYB9bFOfC8tqYazjxtvCWi2Zt02de60rU9Sy8M4DcwHDxp2TjdNS164ytpGlB2CWL8heB3_2FaFSgg8suXWSaQayWvBSsLriVlrvXZ6Qz7v9V02sSY6tMVoVfBPOFZ6WiqeVkA-D9KqvxfEfuWM8ykEGK2iHC4ArFXGl7sJVQl5GIPydC8huLmDkHQJD9Ymqg4ZQU84E0k2U-BQkUEfAchodUx1gU7Da1khyMpKEe7sZDR9G8N2x4MkOmSqqoI1CVx3IVymLhLwfhnECDKvr3PJ6o_IaFHyB9YtguT2Qh4mwjRma0YTIEcRH2zoe6RaXoUA5FxIc3ezgPs7hNXmES-2fek3I3nZ97d4AD9yat-GW_wM-u1iD
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Hindawi Publishing Open Access
  dbid: RHX
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lj9MwELbYlZC4IGB5BAoYaYEDisjDj_hYqq4KB4QQK_Vm2bGtrZRNq7Yr4N8zk7iBLCCQekk8qWP788w38XhMyKnCbblAFNLMcp6yyrm0EqZMwbg4w4vMiz7b50exOGcflnwZkyTtfl_CB2sH7nku34oqA-bLj8gRAAyd8sXyoHAxAxhGKhaZylKuMnaIb7_27MjydAn6u124Bq7NoJBvXqAr_HX1J8J5PW7yF0N0dofcjgySTvshv0tu-PYeOZm24D1ffqevaBfT2X0sPyEbPI-zCwYApUbn32LUa0vXgU7darNuUd-1FH7z1uFmrAbwSD9t14ArmOtbOvNNs8MbuNiwo4Z-NnuKB6g1-B8zv8WF54a-ByfZX67MfXJ-Nv8yW6TxjIW0BqqxT0MuHFPCOs9tcIVzRrLgapUHYypbKFkEH4CmgBXj3svaG2mUr6yrZRkAheUDctzCyz4iVEpweCV3XjLDQNYIXgqmKu6kC8HnCXlz6H9dxwTkeA5GoztHhHONo6XjaCXk5SC96RNv_EXuHQ7lIIPpsrsbACEdZ58uPNDKjAFgrWEsWJMHlzuvSm4L60qZkIcRCD_rAmabCyh5jsDQ_a7UQR3oKWcCuSVKvO4kUCFAc2oT9zVAp2BqrZHkZCQJE7keFZ9G8P2jwZMDMnXUNzuNfjkwrVIWCXkxFGMFGEPX-vXVTucKtHmByYqguT2Qh4rwzDK0mQmRI4iPunVc0q4uumzkXEjwarPH__f2T8gtvOw_Yk3I8X575Z8CrdvbZ92k_gE_rkRw
  priority: 102
  providerName: Hindawi Publishing
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1Zb9QwELZKERIvCCjHwgJGKvCAUnL4SB4QWlZbFSQQQqzUN8uJbbpSmizZrWj_PTPOAakKSHnZeDaO7W-ueDxDyH6Gx3LBUAjCnPOApcYEqdBJAMrFaB6HVrTZPj-LoyX7eMyPd0hfbbSbwM2Vrh3Wk1o25cH5j4t3wPBvPcNzDv57JN-INATTmF8j10EnSWTRT2zYT8AkYRjMGIdZGPAsZH0I_KV_j5STz-HvD-pq-K0HmX3jBL3ln6urbNLLoZV_6KrD2-RWZ2TSWYuKO2THVnfJ3qwCB_v0gr6kPuzTf0_fI2ss2enjBUDu0cV5Fxhb0drRmVmt6wpFYkXhWlQGz2uVAFn6pakBeiAOGjq3ZbnBG7gfsaGaftVbijXWSnzG3Da4N13SDzDZ9nSl75Hl4eLb_CjoyjAEBVgj28BFwrBM5Mby3JnYGC2ZM0UWOa3TPM5k7KwDSwYUHbdWFlZLndk0N4VMHAA1uU92K3jZh4RKCT6x5MZKphnQasETwbKUG2mcs9GEvO7nXxVdjnIslVEq76twrnC1VLdaE_JioF63uTn-Qvcel3KgwYza_kbdfFcdg6rYguUZMsB0rhlzuY6ciYzNEp7HuUnkhDzogPC7LzB-IwEtzxAYqj24OkgMNeNMoPmJFK88BaIYhlPo7ugDTApm3xpRTkeUwOvFqHm_A99_Bjztkal6jlLouoMxlsh4Qp4PzdgBhtlVtj7bqCgDgR9jPiMYbgvkoSMsa4ZqdULkCOKjaR23VKsTn7CcCwmOb_jo36_1mNzEQbTft6Zkd9uc2Sdg8W3zp56ZfwGFNFBi
  priority: 102
  providerName: Scholars Portal
Title Constitutive Expression of Adiponectin in Endothelial Progenitor Cells Protects a Rat Model of Cerebral Ischemia
URI https://search.emarefa.net/detail/BIM-1193167
https://dx.doi.org/10.1155/2017/6809745
https://www.ncbi.nlm.nih.gov/pubmed/29201467
https://www.proquest.com/docview/2407661372
https://www.proquest.com/docview/1973024185
https://pubmed.ncbi.nlm.nih.gov/PMC5671740
https://doaj.org/article/2e11204ebeba44fba1fd1de935b2bd37
Volume 2017
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3rb9MwELdgExJfEDAehVKMNOADipaHHSefUFd1KiCmUTGp3ywntlmlLCltJ-C_585xM4J4SJWlxqc4tn--h32-I-Qwx2u5oCgEYcF5wDKtgyxVSQDCRSsehyZto32eprNz9n7BF37DbePdKnc80TFq3ZS4R36ElgfIkkTEb1dfA8wahaerPoXGTbKPocvQpUssOoMLQ4OhC2Mc5mHA85DtHN85B5s_EkdpFoI6zXsiyUXud9dzFfxXHae-dYE28rflnzTR3x0qf5FQJ3fJHa9a0nGLhXvkhqnvk4NxDWb15Q_6ijpnT7eLfkBWmKjTeQkAt6PT794dtqaNpWO9XDU1MsKawm9aa7ylVQFQ6dm6AcABE1jTiamqDT7AU4gNVXSuthQzq1X4jolZ44l0Rd-B9Wwul-oBOT-Zfp7MAp98IShBB9kGNko1y9NCG15YHWutBLO6zCOrVFbEuYitsaC_gHjjxojSKKFykxW6FIkFeCYPyV4NH_uYUCHAEhZcG8EUA1qV8iRleca10NaaaEDe7MZflj4yOSbIqKSzUDiXOFvSz9aAvOyoV21Ejr_QHeNUdjQYR9s9aNZfpF-WMjagb4YMkFwoxmyhIqsjbfKEF3GhEzEgjzwQrtsClTdKoeY5AkO211U7PiHHnKWodCLFa0eBnAK6Uyp_4QEGBWNu9SiHPUpY4WWv-tCD7z8dHu6QKT0j2sjrZTMgL7pqbACd62rTXG1klAObjzGKEXS3BXLXECYzQ2E6IKIH8d6w9mvq5YULU85TAeZu-OTfn_WU3MZOtLtaQ7K3XV-ZZ6DnbYuRW8wjsn88PT2bj9xuCZQfPmVQfmRYzmeLnw0SVAk
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxELZKKgQXBJRHIFAjtXBAq-7DXmcPCKUhVUJLVFWt1JvrXds00nY3JKlK_xS_kZl9lUU8TpVyyXq0Xtvjb2bseRCyFWFYLigKjhtz7rC-1k4_VIEDwkUr7rsmLLN9TsPxCft8yk_XyI86FgbdKmtMLIBa5wmeke-g5QGyJBD-x_k3B6tG4e1qXUKjZIt9c30FJtvyw-QTrO-27--Njodjp6oq4CQgXFeO9ULNojDWhsdW-1orwaxOIs8q1Y_9SPjWWBDMgNvcGJEYJVRk-rFORGBh3gN47x2yzgIwZTpkfXc0PTyqsR-TkaHTpO9GrsMjl9Wu9pzv-JipOuy7oMDzlhAsagUUAcEK_qtGNtw9R6v8avYn3fd3F85fZOLeQ_KgUmbpoOS-R2TNZI_JxiADQ_7imr6lhXtpcW6_QeZYGrTwSwB8paPvlQNuRnNLB3o2zzOE3ozCb5RpjAtLYWvQw0UOLA6ws6BDk6ZLfID3Hkuq6JFaUazlluI7hmaBd-ApnYC9bi5m6gk5uZWFeUo6GXzsc0KFANtbcG0EUwxoVciDkEV9roW21nhd8r6ef5lUudCxJEcqC5uIc4mrJavV6pLthnpe5gD5C90uLmVDg5m7iwf54qusgED6BjRcl8HeiRVjNlae1Z42UcBjP9aB6JJnFSPc9AVKthdCyyYyhiwDZBtkkgPOQlRzkeJdQYHYBMNJVBViAZOCWb5alL0WJWBK0mreqpjvPwPu1ZwpK-hbypuN2iVvmmbsAN35MpNfLqUXgWDxMW8SDLdk5KYjLJ-G4rtLRIvFW9Pabslm50VidB4KMLDdF__-rE1yb3z85UAeTKb7L8l9HFB5ptYjndXi0rwCLXMVv662NiVnt40mPwEDupDx
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGEIgXBIyPQmFG2uABRU0cO04eECpdq5WhaUJM2ptxYptV6pLSdhr71_jruMvXCOLjaVJfGp_i2D7_7s6-D0J2EgzLBUXB81MhPB4b48WRDj0QLkYL5tuoyvZ5GO0f8w8n4mSD_GhiYdCtssHEEqhNkeEZ-QAtD5AloWQDV7tFHO1N3i2-eVhBCm9am3IaFYsc2MsLMN9Wb6d7sNa7jE3Gn0f7Xl1hwMtA0K49F0SGJ1FqrEidYcZoyZ3JksBpHacskcxZB0IaMFxYKzOrpU5snJpMhg7WIIT33iA3ZSgC3GPypDX2MC0Zuk8yP_E9kfi8cboXYsAwZ3UU-6DKi444LKsGlKHBGv7rVkrcOkX7_GL2Jy34d2fOX6Tj5B65W6u1dFjx4X2yYfMHZGuYg0l_dklf0dLRtDzB3yILLBJaeigA0tLx99oVN6eFo0MzWxQ5gnBO4TfODUaIzWGT0KNlAcwOALSkIzufr_AB3oCsqKaf9JpiVbc5vmNkl3gbPqdTsNzt2Uw_JMfXsiyPyGYOH_uEUCnBCpfCWMk1B1odiTDiSSyMNM7ZoEfeNPOvsjorOhbnmKvSOhJC4WqperV6ZLelXlTZQP5C9x6XsqXBHN7lg2L5VdWQoJgFXdfnsItSzblLdeBMYGwSipSlJpQ98rhmhKu-QN0OImjZRsZQVahsi1FqKHiECi9SvC4pEKVgOJmugy1gUjDfV4ey36EEdMk6zTs18_1nwP2GM1UNgit1tWV75GXbjB2gY19ui_OVChIQMQwzKMFwK0ZuO8JCaijIe0R2WLwzrd2WfHZapkgXkQRT23_678_aJrcBQ9TH6eHBM3IHx1MdrvXJ5np5bp-DurlOX5T7mpIv1w0kPwECDZPB
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Constitutive+Expression+of+Adiponectin+in+Endothelial+Progenitor+Cells+Protects+a+Rat+Model+of+Cerebral+Ischemia&rft.jtitle=Neural+plasticity&rft.au=Zhang%2C+Renwei&rft.au=Xie%2C+Xiaorui&rft.au=Yu%2C+Qing&rft.au=Feng%2C+Hongliang&rft.date=2017-01-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.issn=2090-5904&rft.eissn=1687-5443&rft.volume=2017&rft_id=info:doi/10.1155%2F2017%2F6809745&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2090-5904&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2090-5904&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2090-5904&client=summon