Mediation by differential DNA methylation of known associations between single nucleotide polymorphisms and bladder cancer risk

• Published in: BMC medical genetics Vol. 21; no. 1; pp. 228 - 9
• Main Authors: Jordahl, Kristina M., Phipps, Amanda I., Randolph, Timothy W., Tinker, Lesley F., Nassir, Rami, Hou, Lifang, Anderson, Garnet L., Kelsey, Karl T., White, Emily, Bhatti, Parveen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.11.2020; BioMed Central; BMC
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, Ly - genetics; Antigens, Ly - metabolism; Bladder cancer; Bladder cancer risk SNPs; Cancer; Carcinogenesis - genetics; Carcinogenesis - metabolism; Carcinogenesis - pathology; Carcinoma, Transitional Cell - genetics; Carcinoma, Transitional Cell - metabolism; Carcinoma, Transitional Cell - pathology; Case-Control Studies; Cigarette Smoking - physiopathology; CpG Islands; DNA; DNA Methylation; DNA, Neoplasm - genetics; DNA, Neoplasm - metabolism; Female; Genetic aspects; Health aspects; Humans; Mediation analysis; Methylation; Middle Aged; Oncology, Experimental; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Receptors, Nicotinic - genetics; Receptors, Nicotinic - metabolism; Risk factors; Single nucleotide polymorphisms; Urinary Bladder - metabolism; Urinary Bladder - pathology; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; United States; Bladder cancer risk SNPs; DNA methylation; Bladder cancer; Mediation analysis

Though bladder cancer has been the subject of many well-powered genome-wide association studies, the mechanisms involving bladder-cancer-associated single nucleotide polymorphisms (SNPs) remain largely unknown. This study focuses on rs798766, rs401681, rs2294008, and rs8102137, which have been assoc...