Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis

• Published in: Genome Biology Vol. 19; no. 1; p. 215
• Main Authors: Poetsch, Anna R., Boulton, Simon J., Luscombe, Nicholas M.
• Format: Journal Article
• Language: English
• Published: England BioMed Central 07.12.2018; BMC
• Subjects: Apurinic Acid - analysis; Apurinic sites; Binding sites; Bioinformatics; Cancer; Chemical modification; Chromatin; cold; Deoxyribonucleic acid; DNA; DNA Damage; DNA Repair; Exons; Gene expression; Gene mapping; Genome, Human; Genomes; Genomics; Guanine - analogs & derivatives; Guanine - analysis; Humans; Introns; Molecular modelling; Mutagenesis; Mutation; Mutation rates; Nucleotide sequence; Oxidative Stress; Promoters; regioselectivity; Transcription

DNA is subject to constant chemical modification and damage, which eventually results in variable mutation rates throughout the genome. Although detailed molecular mechanisms of DNA damage and repair are well understood, damage impact and execution of repair across a genome remain poorly defined. To...