Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism

• Published in: Journal of neural transplantation & plasticity Vol. 2016; no. 2016; pp. 1 - 13
• Main Authors: de Kloet, E. R., Molendijk, M. L.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; John Wiley & Sons, Inc; Wiley
• Subjects: Adaptation, Psychological - physiology; Animals; Antidepressants; Behavior; Behavior, Animal; Brain - metabolism; Brain - physiopathology; Coping; Corticosterone; Genetically modified organisms; Genotype & phenotype; Glucocorticoids - physiology; Learning; Limbic System - metabolism; Limbic System - physiopathology; Mental depression; Mice; Pathogenesis; Rats; Receptors, Glucocorticoid - metabolism; Receptors, Glucocorticoid - physiology; Receptors, Mineralocorticoid - metabolism; Receptors, Mineralocorticoid - physiology; Review; Rodents; Stress; Stress (Psychology); Stress, Psychological - metabolism; Stress, Psychological - physiopathology; Stress, Psychological - psychology; Swimming

In the forced swim test (FST) rodents progressively show increased episodes of immobility if immersed in a beaker with water from where escape is not possible. In this test, a compound qualifies as a potential antidepressant if it prevents or delays the transition to this passive (energy conserving)...