Microglial BDNF, PI3K, and p-ERK in the Spinal Cord Are Suppressed by Pulsed Radiofrequency on Dorsal Root Ganglion to Ease SNI-Induced Neuropathic Pain in Rats

• Published in: Pain research & management Vol. 2019; no. 2019; pp. 1 - 15
• Main Authors: Liu, Rongguo, Shi, Xiaomei, Fu, Shaoxiong, Xu, Xueru
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2019; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Analgesics; Animals; Antibiotics; Attention-deficit hyperactivity disorder; Bone cancer; Brain research; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - biosynthesis; Disease Models, Animal; Drug therapy; Electric stimulation therapy; Extracellular Signal-Regulated MAP Kinases - biosynthesis; Ganglia, Spinal - metabolism; Ganglion; Kinases; Male; Microglia - metabolism; Nervous system; Neuralgia - etiology; Neuralgia - metabolism; Neurosciences; Pain; Peripheral Nerve Injuries - complications; Phosphatidylinositol 3-Kinase - biosynthesis; Proteins; Pulsed Radiofrequency Treatment - methods; Rats; Rats, Sprague-Dawley; Rodents; Spinal cord; Spinal Cord - metabolism; Statistical analysis

Background. Pulsed radiofrequency (PRF) on the dorsal root ganglion (DRG) has been applied to alleviate neuropathic pain effectively, yet the mechanisms underlying pain reduction owing to this treatment are not clarified completely. The activated microglia, brain-derived neurotrophic factor (BDNF),...