Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies

T cells modified via chimeric antigen receptors (CARs) have emerged as a promising treatment modality. Unparalleled clinical efficacy recently demonstrated in refractory B-cell malignancy has brought this new form of adoptive immunotherapy to the center stage. Nonetheless, its current success has al...

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Published inJournal of Immunology Research Vol. 2018; no. 2018; pp. 1 - 10
Main Authors Zhang, Yi, Yang, Ge, Hao, He, Sun, Shangjun, Fu, Yang
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects
Adoptive immunotherapy
Animals
Antigens
Cancer
Cancer therapies
Chemotherapy
Chimeric antigen receptors
Clinical trials
Clinical Trials as Topic
Cytokines
Drug dosages
Drug Resistance, Neoplasm
Drug-Related Side Effects and Adverse Reactions
Gene therapy
Humans
Immunology
Immunotherapy
Immunotherapy, Adoptive - methods
Leukemia
Lymphocytes
Lymphocytes B
Lymphocytes T
Lymphoma
Lymphoma, B-Cell - immunology
Lymphoma, B-Cell - therapy
Malignancy
Neurotoxicity
Non-Hodgkin's lymphomas
Receptors, Antigen, T-Cell - genetics
Receptors, Antigen, T-Cell - metabolism
Recombinant Fusion Proteins - genetics
Recurrence
Review
Suicide
Suicide genes
T cell receptors
T cells
T-Lymphocytes - immunology
T-Lymphocytes - transplantation
Therapeutic applications
Transcription activation
Trucks
China
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Abstract T cells modified via chimeric antigen receptors (CARs) have emerged as a promising treatment modality. Unparalleled clinical efficacy recently demonstrated in refractory B-cell malignancy has brought this new form of adoptive immunotherapy to the center stage. Nonetheless, its current success has also highlighted its potential treatment-related toxicities. The adverse events observed in the clinical trials are described in this review, after which, some innovative strategies developed to overcome these unwanted toxicities are outlined, including suicide genes, targeted activation, and other novel strategies.
AbstractList T cells modified via chimeric antigen receptors (CARs) have emerged as a promising treatment modality. Unparalleled clinical efficacy recently demonstrated in refractory B-cell malignancy has brought this new form of adoptive immunotherapy to the center stage. Nonetheless, its current success has also highlighted its potential treatment-related toxicities. The adverse events observed in the clinical trials are described in this review, after which, some innovative strategies developed to overcome these unwanted toxicities are outlined, including suicide genes, targeted activation, and other novel strategies.
T cells modified via chimeric antigen receptors (CARs) have emerged as a promising treatment modality. Unparalleled clinical efficacy recently demonstrated in refractory B-cell malignancy has brought this new form of adoptive immunotherapy to the center stage. Nonetheless, its current success has also highlighted its potential treatment-related toxicities. The adverse events observed in the clinical trials are described in this review, after which, some innovative strategies developed to overcome these unwanted toxicities are outlined, including suicide genes, targeted activation, and other novel strategies.T cells modified via chimeric antigen receptors (CARs) have emerged as a promising treatment modality. Unparalleled clinical efficacy recently demonstrated in refractory B-cell malignancy has brought this new form of adoptive immunotherapy to the center stage. Nonetheless, its current success has also highlighted its potential treatment-related toxicities. The adverse events observed in the clinical trials are described in this review, after which, some innovative strategies developed to overcome these unwanted toxicities are outlined, including suicide genes, targeted activation, and other novel strategies.
Audience Academic
Author Hao, He
Yang, Ge
Fu, Yang
Sun, Shangjun
Zhang, Yi
AuthorAffiliation 4 Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
2 Department of Oncology, Ansteel Group Hospital, Anshan, Liaoning 114000, China
5 Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
1 Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
3 Department of Orthopedics, Ansteel Group Hospital, Anshan, Liaoning 114000, China
AuthorAffiliation_xml – name: 1 Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
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– name: 3 Department of Orthopedics, Ansteel Group Hospital, Anshan, Liaoning 114000, China
– name: 4 Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
– name: 2 Department of Oncology, Ansteel Group Hospital, Anshan, Liaoning 114000, China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/29850622$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/srep18950
10.1371/journal.pone.0128151
10.1016/j.cell.2016.09.011
10.1097/CJI.0b013e3181ee6675
10.1111/imr.12125
10.1097/PPO.0000000000000035
10.1126/scitranslmed.3010162
10.1126/scitranslmed.3005568
10.1158/1078-0432.CCR-12-1449
10.1111/bjh.14680
10.1200/JCO.2014.58.0225
10.1016/j.cell.2016.01.011
10.1200/JCO.2010.28.6963
10.5402/2012/278093
10.1186/s13045-016-0299-5
10.1172/JCI35700
10.1200/JCO.2012.46.6441
10.1126/scitranslmed.3005930
10.1126/scitranslmed.3003761
10.1158/2326-6066.CIR-13-0008
10.1186/s13045-016-0379-6
10.1200/JCO.2006.05.9964
10.1371/journal.pone.0166891
10.1158/0008-5472.CAN-11-3890
10.18632/oncotarget.4071
10.1182/blood-2014-01-545020
10.1182/blood-2015-02-628354
10.1038/mt.2013.17
10.3324/haematol.2008.001677
10.1097/PPO.0000000000000155
10.1126/science.aab4077
10.1089/hum.1995.6.6-813
10.1097/ppo.0000000000000034
10.1056/NEJMoa1407222
10.1182/blood-2014-11-612903
10.1182/blood-2014-01-552174
10.1517/14712598.2015.1046430
10.1016/j.cell.2016.01.012
10.1200/JCO.2008.16.5449
10.1006/mthe.2001.0433
10.1182/blood-2015-06-650812
10.1200/JCO.2015.64.5929
10.1186/s13045-017-0444-9
10.1007/s10875-012-9689-9
10.1056/NEJMoa1215134
10.1038/leu.2015.52
10.1126/science.276.5319.1719
10.1126/scitranslmed.aac5415
10.1172/JCI84813
10.1186/s13045-015-0195-4
10.1186/s13045-015-0227-0
10.1038/mtna.2013.32
10.1371/journal.pone.0082742
10.1126/science.1088547
10.1182/blood-2013-11-492231
10.1186/s13045-017-0474-3
10.1158/2326-6066.CIR-13-0170
10.3324/haematol.2014.112748
10.1126/scitranslmed.3006034
10.1016/S1470-2045(14)71170-2
10.1126/scitranslmed.aaf8621
10.1586/eci.09.31
10.1186/s13045-017-0453-8
10.1126/scitranslmed.3006597
10.1038/mto.2016.11
10.3389/fphar.2014.00254
10.1016/j.bbmt.2010.03.014
10.3389/fphar.2014.00235
10.1016/j.pharmthera.2017.03.012
10.1126/science.1076514
10.1182/blood-2010-07-294520
10.1182/blood-2013-03-490565
10.1515/hsz-2014-0178
10.1186/s12967-015-0460-x
10.1200/JCO.2014.59.1586
10.1007/s00262-014-1641-9
10.1126/science.aad5289
10.1056/NEJMra0904569
10.1200/JCO.2014.56.2025
10.1002/jgm.2604
10.1182/blood-2004-11-4564
10.1056/NEJMoa1106152
10.1182/blood-2013-11-541235
10.1126/scitranslmed.3008226
10.1172/JCI85309
10.1056/NEJMoa1112802
10.1158/0008-5472.CAN-13-1365
10.1182/blood-2014-05-552729
10.1038/gt.2010.91
10.1158/1078-0432.CCR-06-1183
10.1016/j.ymthe.2016.10.012
10.1097/CCM.0000000000002053
10.1038/leu.2010.75
10.1073/pnas.1524155113
10.1111/imr.12131
10.1038/nrc3322
10.1021/jacs.5b00106
10.1016/S0140-6736(14)61403-3
10.1172/JCI83092
10.1182/blood-2014-01-551671
10.1158/0008-5472.CAN-11-3898
10.1182/blood-2009-03-209650
10.1056/NEJMoa1103849
10.1182/blood-2013-02-485623
10.1038/nbt.2459
ContentType Journal Article
Copyright Copyright © 2018 Shangjun Sun et al.
COPYRIGHT 2018 John Wiley & Sons, Inc.
Copyright © 2018 Shangjun Sun et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2018 Shangjun Sun et al. 2018
Copyright_xml – notice: Copyright © 2018 Shangjun Sun et al.
– notice: COPYRIGHT 2018 John Wiley & Sons, Inc.
– notice: Copyright © 2018 Shangjun Sun et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2018 Shangjun Sun et al. 2018
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References 88
89
90
91
92
93
94
95
96
97
10
98
11
99
12
13
14
15
16
17
18
19
1
2
3
4
5
6
7
8
9
20
21
22
23
24
25
26
27
28
29
(30) 2003; 63
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
100
101
102
103
104
105
106
80
81
82
83
84
85
86
87
26759369 - Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):E459-68
27632680 - Crit Care Med. 2017 Feb;45(2):e124-e131
27626062 - Mol Ther Oncolytics. 2016 Apr 20;3:16011
15728125 - Blood. 2005 Jun 1;105(11):4247-54
22553251 - Sci Transl Med. 2012 May 2;4(132):132ra53
24667958 - Cancer J. 2014 Mar-Apr;20(2):127-33
26041741 - Blood. 2015 Jul 30;126(5):629-39
23304553 - ISRN Oncol. 2012;2012:278093
23515080 - Sci Transl Med. 2013 Mar 20;5(177):177ra38
18688285 - J Clin Invest. 2008 Sep;118(9):3132-42
23552369 - Sci Transl Med. 2013 Apr 3;5(179):179ps7
24782509 - Blood. 2014 Jun 12;123(24):3750-9
27907031 - PLoS One. 2016 Dec 1;11(12 ):e0166891
26405231 - Science. 2015 Oct 16;350(6258):aab4077
20889925 - Blood. 2011 Jan 6;117(1):72-82
9180086 - Science. 1997 Jun 13;276(5319):1719-24
23839099 - Mol Ther Nucleic Acids. 2013 Jul 09;2:e105
27526682 - J Hematol Oncol. 2016 Aug 15;9(1):70
20555360 - Gene Ther. 2010 Oct;17(10):1206-13
25488419 - Cancer Immunol Immunother. 2015 Jan;64(1):123-30
25317870 - N Engl J Med. 2014 Oct 16;371(16):1507-17
19734426 - Haematologica. 2009 Sep;94(9):1316-20
14633720 - Cancer Res. 2003 Nov 15;63(22):7907-12
22315351 - Cancer Res. 2012 Apr 1;72 (7):1844-52
17062687 - Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6106-15
26333935 - Sci Transl Med. 2015 Sep 2;7(303):303ra139
28482851 - J Hematol Oncol. 2017 May 8;10 (1):103
20428207 - Leukemia. 2010 Jun;24(6):1160-70
27605551 - Sci Transl Med. 2016 Sep 7;8(355):355ra116
24553386 - Sci Transl Med. 2014 Feb 19;6(224):224ra25
26884582 - J Clin Oncol. 2016 Apr 1;34(10):1104-11
26811520 - J Clin Oncol. 2016 Apr 1;34(10 ):1112-21
24667956 - Cancer J. 2014 Mar-Apr;20(2):119-22
24970931 - Blood. 2014 Aug 21;124(8):1277-87
25154820 - J Clin Oncol. 2015 Feb 20;33(6):540-9
28356156 - J Hematol Oncol. 2017 Mar 29;10 (1):78
23527958 - N Engl J Med. 2013 Apr 18;368(16):1509-1518
20842059 - J Immunother. 2010 Oct;33(8):780-8
27693353 - Cell. 2016 Oct 6;167(2):419-432.e16
25319501 - Lancet. 2015 Feb 7;385(9967):517-528
27111235 - J Clin Invest. 2016 Jun 1;126(6):2123-38
25985798 - Expert Opin Biol Ther. 2015;15(8):1145-54
25524800 - Lancet Oncol. 2015 Jan;16(1):57-66
20477639 - Expert Rev Clin Immunol. 2009 Sep;5(5):499-521
25890361 - J Transl Med. 2015 Mar 28;13:102
25505885 - Front Pharmacol. 2014 Nov 27;5:254
14564000 - Science. 2003 Oct 17;302(5644):415-9
25480499 - Haematologica. 2015 Mar;100(3):336-44
24409448 - Cancer Immunol Res. 2013 Jul;1(1):43-53
26750734 - Sci Rep. 2016 Jan 11;6:18950
26228169 - Blood. 2015 Jul 30;126(5):567-9
25389405 - Front Pharmacol. 2014 Oct 28;5:235
12242449 - Science. 2002 Oct 25;298(5594):850-4
28049484 - J Hematol Oncol. 2017 Jan 3;10 (1):1
24358223 - PLoS One. 2013 Dec 17;8(12):e82742
24329791 - Immunol Rev. 2014 Jan;257(1):83-90
28369673 - Br J Haematol. 2018 Jun;181(5):689-692
25378643 - Sci Transl Med. 2014 Nov 5;6(261):261ra151
18809613 - J Clin Oncol. 2008 Nov 10;26(32):5233-9
23032741 - Clin Cancer Res. 2012 Dec 1;18(23):6436-45
24337479 - Sci Transl Med. 2013 Dec 11;5(215):215ra172
20921459 - J Clin Oncol. 2010 Nov 1;28(31):4722-9
22526592 - J Clin Immunol. 2012 Oct;32(5):1059-70
26337639 - J Hematol Oncol. 2015 Sep 04;8:104
20304086 - Biol Blood Marrow Transplant. 2010 Sep;16(9):1245-56
27760047 - J Clin Invest. 2016 Nov 1;126(11):4262-4272
11482986 - Mol Ther. 2001 Aug;4(2):146-8
22262649 - J Gene Med. 2012 Jun;14(6):405-15
26030772 - PLoS One. 2015 Jun 01;10(6):e0128151
25800760 - J Clin Oncol. 2015 May 20;33(15):1688-96
25205716 - Biol Chem. 2014 Nov 1;395(11):1341-52
23423337 - Mol Ther. 2013 Apr;21(4):904-12
26516270 - Science. 2015 Oct 30;350(6260):514-5
24329793 - Immunol Rev. 2014 Jan;257(1):107-26
23242161 - Nat Biotechnol. 2013 Jan;31(1):71-5
27454297 - J Clin Invest. 2016 Aug 1;126(8):3130-44
22659454 - Cancer Res. 2012 Jun 15;72(12):2924-30
24876563 - Blood. 2014 Jul 10;124(2):188-95
28434396 - J Hematol Oncol. 2017 Apr 24;10 (1):94
24578504 - Blood. 2014 Apr 24;123(17):2625-35
28342824 - Pharmacol Ther. 2017 Oct;178:83-91
28129120 - Mol Ther. 2017 Jan 4;25(1):259-273
25721896 - Leukemia. 2015 Aug;29(8):1637-47
24753538 - Blood. 2014 Jun 19;123(25):3895-905
24579088 - Cancer Immunol Res. 2014 Feb;2(2):112-20
23252525 - N Engl J Med. 2012 Dec 20;367 (25):2385-95
26830878 - Cell. 2016 Feb 11;164(4):780-91
22996603 - Nat Rev Cancer. 2012 Oct;12(10):671-84
26101914 - Oncotarget. 2015 Aug 28;6(25):21533-46
21561350 - N Engl J Med. 2011 May 12;364(19):1844-54
19377047 - Blood. 2009 Jun 18;113(25):6392-402
16648493 - J Clin Oncol. 2006 May 1;24(13):e20-2
22047558 - N Engl J Med. 2011 Nov 3;365(18):1673-83
26588679 - Cancer J. 2015 Nov-Dec;21(6):475-9
23770775 - Blood. 2013 Aug 8;122(6):863-71
26830879 - Cell. 2016 Feb 11;164(4):770-9
21830940 - N Engl J Med. 2011 Aug 25;365(8):725-33
7548281 - Hum Gene Ther. 1995 Jun;6(6):813-9
26692321 - J Hematol Oncol. 2015 Dec 21;8:130
24197131 - Cancer Res. 2014 Jan 1;74(1):93-103
23926201 - Sci Transl Med. 2013 Aug 7;5(197):197ra103
25049283 - Blood. 2014 Oct 30;124(18):2824-33
25692571 - J Am Chem Soc. 2015 Mar 4;137(8):2832-5
23678006 - Blood. 2013 Jun 27;121(26):5154-7
23650429 - J Clin Oncol. 2013 Jun 10;31(17):2152-9
25977584 - Blood. 2015 Jun 25;125(26):4103-13
References_xml – ident: 85
  doi: 10.1038/srep18950
– ident: 94
  doi: 10.1371/journal.pone.0128151
– ident: 81
  doi: 10.1016/j.cell.2016.09.011
– ident: 101
  doi: 10.1097/CJI.0b013e3181ee6675
– ident: 102
  doi: 10.1111/imr.12125
– ident: 25
  doi: 10.1097/PPO.0000000000000035
– ident: 99
  doi: 10.1126/scitranslmed.3010162
– ident: 1
  doi: 10.1126/scitranslmed.3005568
– ident: 90
  doi: 10.1158/1078-0432.CCR-12-1449
– ident: 43
  doi: 10.1111/bjh.14680
– ident: 13
  doi: 10.1200/JCO.2014.58.0225
– ident: 82
  doi: 10.1016/j.cell.2016.01.011
– ident: 31
  doi: 10.1200/JCO.2010.28.6963
– ident: 17
  doi: 10.5402/2012/278093
– ident: 40
  doi: 10.1186/s13045-016-0299-5
– ident: 54
  doi: 10.1172/JCI35700
– ident: 46
  doi: 10.1200/JCO.2012.46.6441
– ident: 22
  doi: 10.1126/scitranslmed.3005930
– ident: 55
  doi: 10.1126/scitranslmed.3003761
– ident: 74
  doi: 10.1158/2326-6066.CIR-13-0008
– ident: 86
  doi: 10.1186/s13045-016-0379-6
– ident: 27
  doi: 10.1200/JCO.2006.05.9964
– ident: 71
  doi: 10.1371/journal.pone.0166891
– ident: 91
  doi: 10.1158/0008-5472.CAN-11-3890
– ident: 97
  doi: 10.18632/oncotarget.4071
– ident: 62
  doi: 10.1182/blood-2014-01-545020
– ident: 68
  doi: 10.1182/blood-2015-02-628354
– ident: 28
  doi: 10.1038/mt.2013.17
– ident: 61
  doi: 10.3324/haematol.2008.001677
– ident: 98
  doi: 10.1097/PPO.0000000000000155
– ident: 84
  doi: 10.1126/science.aab4077
– ident: 56
  doi: 10.1089/hum.1995.6.6-813
– ident: 76
  doi: 10.1097/ppo.0000000000000034
– ident: 3
  doi: 10.1056/NEJMoa1407222
– ident: 34
  doi: 10.1182/blood-2014-11-612903
– ident: 106
  doi: 10.1182/blood-2014-01-552174
– ident: 103
  doi: 10.1517/14712598.2015.1046430
– ident: 80
  doi: 10.1016/j.cell.2016.01.012
– ident: 45
  doi: 10.1200/JCO.2008.16.5449
– ident: 59
  doi: 10.1006/mthe.2001.0433
– ident: 33
  doi: 10.1182/blood-2015-06-650812
– ident: 10
  doi: 10.1200/JCO.2015.64.5929
– ident: 15
  doi: 10.1186/s13045-017-0444-9
– ident: 73
  doi: 10.1007/s10875-012-9689-9
– ident: 7
  doi: 10.1056/NEJMoa1215134
– ident: 35
  doi: 10.1038/leu.2015.52
– ident: 57
  doi: 10.1126/science.276.5319.1719
– ident: 8
  doi: 10.1126/scitranslmed.aac5415
– ident: 64
  doi: 10.1172/JCI84813
– ident: 87
  doi: 10.1186/s13045-015-0195-4
– ident: 88
  doi: 10.1186/s13045-015-0227-0
– ident: 75
  doi: 10.1038/mtna.2013.32
– ident: 69
  doi: 10.1371/journal.pone.0082742
– ident: 53
  doi: 10.1126/science.1088547
– ident: 51
  doi: 10.1182/blood-2013-11-492231
– ident: 78
  doi: 10.1186/s13045-017-0474-3
– ident: 12
  doi: 10.1158/2326-6066.CIR-13-0170
– ident: 36
  doi: 10.3324/haematol.2014.112748
– ident: 37
  doi: 10.1126/scitranslmed.3006034
– ident: 41
  doi: 10.1016/S1470-2045(14)71170-2
– ident: 96
  doi: 10.1126/scitranslmed.aaf8621
– ident: 18
  doi: 10.1586/eci.09.31
– ident: 77
  doi: 10.1186/s13045-017-0453-8
– ident: 79
  doi: 10.1126/scitranslmed.3006597
– ident: 23
  doi: 10.1038/mto.2016.11
– ident: 58
  doi: 10.3389/fphar.2014.00254
– ident: 49
  doi: 10.1016/j.bbmt.2010.03.014
– ident: 65
  doi: 10.3389/fphar.2014.00235
– ident: 83
  doi: 10.1016/j.pharmthera.2017.03.012
– ident: 44
  doi: 10.1126/science.1076514
– ident: 50
  doi: 10.1182/blood-2010-07-294520
– ident: 38
  doi: 10.1182/blood-2013-03-490565
– ident: 39
  doi: 10.1515/hsz-2014-0178
– ident: 63
  doi: 10.1186/s12967-015-0460-x
– ident: 42
  doi: 10.1200/JCO.2014.59.1586
– ident: 52
  doi: 10.1007/s00262-014-1641-9
– ident: 2
  doi: 10.1126/science.aad5289
– volume: 63
  start-page: 7907
  issue: 22
  year: 2003
  ident: 30
  publication-title: Cancer Research
– ident: 21
  doi: 10.1056/NEJMra0904569
– ident: 11
  doi: 10.1200/JCO.2014.56.2025
– ident: 47
  doi: 10.1002/jgm.2604
– ident: 60
  doi: 10.1182/blood-2004-11-4564
– ident: 66
  doi: 10.1056/NEJMoa1106152
– ident: 105
  doi: 10.1182/blood-2013-11-541235
– ident: 5
  doi: 10.1126/scitranslmed.3008226
– ident: 6
  doi: 10.1172/JCI85309
– ident: 26
  doi: 10.1056/NEJMoa1112802
– ident: 89
  doi: 10.1158/0008-5472.CAN-13-1365
– ident: 19
  doi: 10.1182/blood-2014-05-552729
– ident: 29
  doi: 10.1038/gt.2010.91
– ident: 48
  doi: 10.1158/1078-0432.CCR-06-1183
– ident: 14
  doi: 10.1016/j.ymthe.2016.10.012
– ident: 20
  doi: 10.1097/CCM.0000000000002053
– ident: 70
  doi: 10.1038/leu.2010.75
– ident: 92
  doi: 10.1073/pnas.1524155113
– ident: 16
  doi: 10.1111/imr.12131
– ident: 104
  doi: 10.1038/nrc3322
– ident: 93
  doi: 10.1021/jacs.5b00106
– ident: 4
  doi: 10.1016/S0140-6736(14)61403-3
– ident: 95
  doi: 10.1172/JCI83092
– ident: 67
  doi: 10.1182/blood-2014-01-551671
– ident: 32
  doi: 10.1158/0008-5472.CAN-11-3898
– ident: 100
  doi: 10.1182/blood-2009-03-209650
– ident: 9
  doi: 10.1056/NEJMoa1103849
– ident: 24
  doi: 10.1182/blood-2013-02-485623
– ident: 72
  doi: 10.1038/nbt.2459
– reference: 24358223 - PLoS One. 2013 Dec 17;8(12):e82742
– reference: 24579088 - Cancer Immunol Res. 2014 Feb;2(2):112-20
– reference: 23552369 - Sci Transl Med. 2013 Apr 3;5(179):179ps7
– reference: 16648493 - J Clin Oncol. 2006 May 1;24(13):e20-2
– reference: 28369673 - Br J Haematol. 2018 Jun;181(5):689-692
– reference: 23252525 - N Engl J Med. 2012 Dec 20;367 (25):2385-95
– reference: 26041741 - Blood. 2015 Jul 30;126(5):629-39
– reference: 7548281 - Hum Gene Ther. 1995 Jun;6(6):813-9
– reference: 26750734 - Sci Rep. 2016 Jan 11;6:18950
– reference: 24667958 - Cancer J. 2014 Mar-Apr;20(2):127-33
– reference: 26830879 - Cell. 2016 Feb 11;164(4):770-9
– reference: 25977584 - Blood. 2015 Jun 25;125(26):4103-13
– reference: 18688285 - J Clin Invest. 2008 Sep;118(9):3132-42
– reference: 25890361 - J Transl Med. 2015 Mar 28;13:102
– reference: 23032741 - Clin Cancer Res. 2012 Dec 1;18(23):6436-45
– reference: 25389405 - Front Pharmacol. 2014 Oct 28;5:235
– reference: 27907031 - PLoS One. 2016 Dec 1;11(12 ):e0166891
– reference: 24329793 - Immunol Rev. 2014 Jan;257(1):107-26
– reference: 23770775 - Blood. 2013 Aug 8;122(6):863-71
– reference: 28482851 - J Hematol Oncol. 2017 May 8;10 (1):103
– reference: 24782509 - Blood. 2014 Jun 12;123(24):3750-9
– reference: 26830878 - Cell. 2016 Feb 11;164(4):780-91
– reference: 24753538 - Blood. 2014 Jun 19;123(25):3895-905
– reference: 24337479 - Sci Transl Med. 2013 Dec 11;5(215):215ra172
– reference: 26228169 - Blood. 2015 Jul 30;126(5):567-9
– reference: 25480499 - Haematologica. 2015 Mar;100(3):336-44
– reference: 11482986 - Mol Ther. 2001 Aug;4(2):146-8
– reference: 25488419 - Cancer Immunol Immunother. 2015 Jan;64(1):123-30
– reference: 20921459 - J Clin Oncol. 2010 Nov 1;28(31):4722-9
– reference: 26101914 - Oncotarget. 2015 Aug 28;6(25):21533-46
– reference: 15728125 - Blood. 2005 Jun 1;105(11):4247-54
– reference: 19734426 - Haematologica. 2009 Sep;94(9):1316-20
– reference: 26759369 - Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):E459-68
– reference: 12242449 - Science. 2002 Oct 25;298(5594):850-4
– reference: 28129120 - Mol Ther. 2017 Jan 4;25(1):259-273
– reference: 28356156 - J Hematol Oncol. 2017 Mar 29;10 (1):78
– reference: 23515080 - Sci Transl Med. 2013 Mar 20;5(177):177ra38
– reference: 25800760 - J Clin Oncol. 2015 May 20;33(15):1688-96
– reference: 25692571 - J Am Chem Soc. 2015 Mar 4;137(8):2832-5
– reference: 14564000 - Science. 2003 Oct 17;302(5644):415-9
– reference: 26516270 - Science. 2015 Oct 30;350(6260):514-5
– reference: 20428207 - Leukemia. 2010 Jun;24(6):1160-70
– reference: 23423337 - Mol Ther. 2013 Apr;21(4):904-12
– reference: 18809613 - J Clin Oncol. 2008 Nov 10;26(32):5233-9
– reference: 25721896 - Leukemia. 2015 Aug;29(8):1637-47
– reference: 26588679 - Cancer J. 2015 Nov-Dec;21(6):475-9
– reference: 26333935 - Sci Transl Med. 2015 Sep 2;7(303):303ra139
– reference: 23304553 - ISRN Oncol. 2012;2012:278093
– reference: 25319501 - Lancet. 2015 Feb 7;385(9967):517-528
– reference: 22047558 - N Engl J Med. 2011 Nov 3;365(18):1673-83
– reference: 20889925 - Blood. 2011 Jan 6;117(1):72-82
– reference: 27605551 - Sci Transl Med. 2016 Sep 7;8(355):355ra116
– reference: 27632680 - Crit Care Med. 2017 Feb;45(2):e124-e131
– reference: 25205716 - Biol Chem. 2014 Nov 1;395(11):1341-52
– reference: 24970931 - Blood. 2014 Aug 21;124(8):1277-87
– reference: 26692321 - J Hematol Oncol. 2015 Dec 21;8:130
– reference: 9180086 - Science. 1997 Jun 13;276(5319):1719-24
– reference: 20842059 - J Immunother. 2010 Oct;33(8):780-8
– reference: 24578504 - Blood. 2014 Apr 24;123(17):2625-35
– reference: 23242161 - Nat Biotechnol. 2013 Jan;31(1):71-5
– reference: 23650429 - J Clin Oncol. 2013 Jun 10;31(17):2152-9
– reference: 20477639 - Expert Rev Clin Immunol. 2009 Sep;5(5):499-521
– reference: 28342824 - Pharmacol Ther. 2017 Oct;178:83-91
– reference: 22315351 - Cancer Res. 2012 Apr 1;72 (7):1844-52
– reference: 27454297 - J Clin Invest. 2016 Aug 1;126(8):3130-44
– reference: 23678006 - Blood. 2013 Jun 27;121(26):5154-7
– reference: 24409448 - Cancer Immunol Res. 2013 Jul;1(1):43-53
– reference: 24329791 - Immunol Rev. 2014 Jan;257(1):83-90
– reference: 20555360 - Gene Ther. 2010 Oct;17(10):1206-13
– reference: 14633720 - Cancer Res. 2003 Nov 15;63(22):7907-12
– reference: 23527958 - N Engl J Med. 2013 Apr 18;368(16):1509-1518
– reference: 23839099 - Mol Ther Nucleic Acids. 2013 Jul 09;2:e105
– reference: 25154820 - J Clin Oncol. 2015 Feb 20;33(6):540-9
– reference: 26030772 - PLoS One. 2015 Jun 01;10(6):e0128151
– reference: 22996603 - Nat Rev Cancer. 2012 Oct;12(10):671-84
– reference: 25378643 - Sci Transl Med. 2014 Nov 5;6(261):261ra151
– reference: 21561350 - N Engl J Med. 2011 May 12;364(19):1844-54
– reference: 22262649 - J Gene Med. 2012 Jun;14(6):405-15
– reference: 26884582 - J Clin Oncol. 2016 Apr 1;34(10):1104-11
– reference: 26405231 - Science. 2015 Oct 16;350(6258):aab4077
– reference: 22553251 - Sci Transl Med. 2012 May 2;4(132):132ra53
– reference: 24667956 - Cancer J. 2014 Mar-Apr;20(2):119-22
– reference: 28049484 - J Hematol Oncol. 2017 Jan 3;10 (1):1
– reference: 24876563 - Blood. 2014 Jul 10;124(2):188-95
– reference: 28434396 - J Hematol Oncol. 2017 Apr 24;10 (1):94
– reference: 27693353 - Cell. 2016 Oct 6;167(2):419-432.e16
– reference: 26811520 - J Clin Oncol. 2016 Apr 1;34(10 ):1112-21
– reference: 25524800 - Lancet Oncol. 2015 Jan;16(1):57-66
– reference: 23926201 - Sci Transl Med. 2013 Aug 7;5(197):197ra103
– reference: 27111235 - J Clin Invest. 2016 Jun 1;126(6):2123-38
– reference: 24553386 - Sci Transl Med. 2014 Feb 19;6(224):224ra25
– reference: 20304086 - Biol Blood Marrow Transplant. 2010 Sep;16(9):1245-56
– reference: 25317870 - N Engl J Med. 2014 Oct 16;371(16):1507-17
– reference: 27526682 - J Hematol Oncol. 2016 Aug 15;9(1):70
– reference: 17062687 - Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6106-15
– reference: 27626062 - Mol Ther Oncolytics. 2016 Apr 20;3:16011
– reference: 27760047 - J Clin Invest. 2016 Nov 1;126(11):4262-4272
– reference: 22659454 - Cancer Res. 2012 Jun 15;72(12):2924-30
– reference: 22526592 - J Clin Immunol. 2012 Oct;32(5):1059-70
– reference: 25505885 - Front Pharmacol. 2014 Nov 27;5:254
– reference: 19377047 - Blood. 2009 Jun 18;113(25):6392-402
– reference: 24197131 - Cancer Res. 2014 Jan 1;74(1):93-103
– reference: 26337639 - J Hematol Oncol. 2015 Sep 04;8:104
– reference: 21830940 - N Engl J Med. 2011 Aug 25;365(8):725-33
– reference: 25049283 - Blood. 2014 Oct 30;124(18):2824-33
– reference: 25985798 - Expert Opin Biol Ther. 2015;15(8):1145-54
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Snippet T cells modified via chimeric antigen receptors (CARs) have emerged as a promising treatment modality. Unparalleled clinical efficacy recently demonstrated in...
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SubjectTerms Adoptive immunotherapy
Animals
Antigens
Cancer
Cancer therapies
Chemotherapy
Chimeric antigen receptors
Clinical trials
Clinical Trials as Topic
Cytokines
Drug dosages
Drug Resistance, Neoplasm
Drug-Related Side Effects and Adverse Reactions
Gene therapy
Humans
Immunology
Immunotherapy
Immunotherapy, Adoptive - methods
Leukemia
Lymphocytes
Lymphocytes B
Lymphocytes T
Lymphoma
Lymphoma, B-Cell - immunology
Lymphoma, B-Cell - therapy
Malignancy
Neurotoxicity
Non-Hodgkin's lymphomas
Receptors, Antigen, T-Cell - genetics
Receptors, Antigen, T-Cell - metabolism
Recombinant Fusion Proteins - genetics
Recurrence
Review
Suicide
Suicide genes
T cell receptors
T cells
T-Lymphocytes - immunology
T-Lymphocytes - transplantation
Therapeutic applications
Transcription activation
Trucks
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Title Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies
URI https://search.emarefa.net/detail/BIM-1191763
https://dx.doi.org/10.1155/2018/2386187
https://www.ncbi.nlm.nih.gov/pubmed/29850622
https://www.proquest.com/docview/2032395142
https://www.proquest.com/docview/2047920913
https://pubmed.ncbi.nlm.nih.gov/PMC5932485
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Volume 2018
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