TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Is Involved in Glucose Metabolism in Adipose Tissue through the Insulin/AKT Signaling Pathway

• Published in: International journal of endocrinology Vol. 2020; no. 2020; pp. 1 - 9
• Main Authors: Yang, Junling, Fukuchi, Ken-Ichiro
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 09.12.2020; Hindawi; John Wiley & Sons, Inc; Hindawi Limited; Wiley
• Subjects: Adipocytes; Adipose tissues; Biological response modifiers; Blood sugar monitoring; Body fat; Cardiovascular disease; Cytokines; Development and progression; Dextrose; Diabetes; Endocrinology; Genetic research; Glucose; Glucose metabolism; Inflammation; Insulin; Insulin resistance; Interferon; Kinases; Metabolic disorders; Obesity; Pathogens; Plasma; Type 2 diabetes; St Louis Missouri; United States > US; Pittsburgh Pennsylvania

Obesity significantly increases the risk of developing type 2 diabetes mellitus and other metabolic diseases. Obesity is associated with chronic low-grade inflammation in white adipose tissues, which is thought to play an essential role in developing insulin resistance. Many lines of evidence indica...