Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2

• Published in: Cell Death & Disease Vol. 12; no. 6; pp. 515 - 17
• Main Authors: Amancio Carnero, Manuel P. Jiménez-García, Daniel Otero-Albiol, Antonio Lucena-Cacace
• Format: Journal Article
• Language: English
• Published: London Springer Science and Business Media LLC 20.05.2021; Nature Publishing Group UK; Springer Nature B.V; Nature Publishing Group
• Subjects: 13; 14/1; 14/63; 38; 42; 45; 45/100; 45/22; 45/61; 45/90; 631/67/1798; 631/67/71; 64/110; 82/80; 96/106; 96/95; Animal models; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Cancer; Cancer Stem Cell; Carcinogenesis; Cell Biology; Cell Culture; Cell differentiation; Cell Line, Tumor; Cell proliferation; Cell self-renewal; Cytology; Embryogenesis; Empty Spiracles Homeobox; EMX; EMX1; EMX2; Gene expression; Genes, Homeobox; Heterografts; Homeobox; Homeodomain Proteins; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; Immunology; KLF4 protein; Kruppel-Like Factor 4; Life Sciences; Medical Subject Headings::Anatomy::Body Regions::Transplants::Heterografts; Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor; Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells; Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Homeodomain Proteins; Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors; Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma; Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Carcinogenesis::Cocarcinogenesis; Medical Subject Headings::Organisms::Eukaryota::Animals; Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic::Mice, Knockout; Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL; Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred CBA; Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans; Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Developmental::Genes, Homeobox; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Myc protein; Neoplastic Stem Cells; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Nestin; Neural crest; Neural stem cells; Oct-4 protein; OSKM; Phenotypes; QH573-671; Sarcoma; Sarcoma - genetics; Sarcoma - metabolism; Sarcoma - pathology; Sarcomagenesis; Spiracles; Stem cell transplantation; Stem cells; Stemness; Transcription Factors; Transcription Factors - genetics; Transcription Factors - metabolism; Transgenic Mice; Tumor suppressor genes

The EMX (Empty Spiracles Homeobox) genes EMX1 and EMX2 are two homeodomain gene members of the EMX family of transcription factors involved in the regulation of various biological processes, such as cell proliferation, migration, and differentiation, during brain development and neural crest migrati...