Construction of a recombinant vaccine expressing Nipah virus glycoprotein using the replicative and highly attenuated vaccinia virus strain LC16m8

• Published in: PLoS neglected tropical diseases Vol. 17; no. 12; p. e0011851
• Main Authors: Watanabe, Shumpei, Yoshikawa, Tomoki, Kaku, Yoshihiro, Kurosu, Takeshi, Fukushi, Shuetsu, Sugimoto, Satoko, Nishisaka, Yuki, Fuji, Hikaru, Marsh, Glenn, Maeda, Ken, Ebihara, Hideki, Morikawa, Shigeru, Shimojima, Masayuki, Saijo, Masayuki
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2023; Public Library of Science (PLoS)
• Subjects: Antibodies; Antigenicity; Diagnosis; Disease control; Drug dosages; Encephalitis; Epidemics; Epidemiology; Experiments; FDA approval; Fusion protein; Genetic aspects; Genomes; Glycoproteins; Hamsters; Henipavirus; Henipaviruses; Infections; Inoculation; Monkeypox; Nipah virus; Plasmids; Proteins; Recombinants; Respiratory diseases; Respiratory disorders; Smallpox; Vaccines; Vectors; Viruses; Zoonoses; Japan; Ankara Turkey; Malaysia; Turkey; United States > US

Nipah virus (NiV) is a highly pathogenic zoonotic virus that causes severe encephalitis and respiratory diseases and has a high mortality rate in humans (>40%). Epidemiological studies on various fruit bat species, which are natural reservoirs of the virus, have shown that NiV is widely distribut...