Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance

• Published in: Diabetes (New York, N.Y.) Vol. 60; no. 8; pp. 2051 - 2060
• Main Authors: Ghosh, Sangeeta, Lertwattanarak, Raweewan, Lefort, Natalie, Molina-Carrion, Marjorie, Joya-Galeana, Joaquin, Bowen, Benjamin P., Garduno-Garcia, Jose de Jesus, Abdul-Ghani, Muhammad, Richardson, Arlan, DeFronzo, Ralph A., Mandarino, Lawrence, Van Remmen, Holly, Musi, Nicolas
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.08.2011
• Subjects: 60 APPLIED LIFE SCIENCES; Adenosine Triphosphate - biosynthesis; Adolescent; Adult; Age; Aged; Aging - physiology; BASIC BIOLOGICAL SCIENCES; Biological and medical sciences; Biopsy; Development and progression; Diabetes; Diabetes. Impaired glucose tolerance; Diagnosis; DNA-Binding Proteins; Endocrine pancreas. Apud cells (diseases); Endocrinology & Metabolism; Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Exercise; Free radicals; Gene Expression Profiling; Glucose; Glucose Intolerance - physiopathology; Glucose tolerance test; Glucose tolerance tests; Heat-Shock Proteins - biosynthesis; Homeostasis; Humans; Insulin resistance; Lipid Peroxidation; Lipids; Medical sciences; Metabolism; Mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Mitochondrial Proteins; Nuclear Respiratory Factor 1 - biosynthesis; Oxidative stress; Pathogenesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical fitness; Physiological aspects; Proteins; Proteomics; Reactive Oxygen Species - metabolism; Research design; Theories of aging; Transcription Factors - biosynthesis; Type 2 diabetes; United States; Endocrinopathy; Human; Mitochondria; Oxygen; Diabetes mellitus; Impaired glucose tolerance; Elderly

Aging increases the risk of developing impaired glucose tolerance (IGT) and type 2 diabetes. It has been proposed that increased reactive oxygen species (ROS) generation by dysfunctional mitochondria could play a role in the pathogenesis of these metabolic abnormalities. We examined whether aging pe...