Aging Induced p53/p21 in Genioglossus Muscle Stem Cells and Enhanced Upper Airway Injury

• Published in: Stem cells international Vol. 2020; no. 2020; pp. 1 - 13
• Main Authors: Liu, Yuehua, Han, Xin-Xin, Zhang, Meng-Han, Huang, Wei, Liu, Shang-Feng, Deng, Jia-Jia, Zhang, Wei-Hua, Yu, Liming, Zhu, Lu-Ying, Lu, Yan-Qin
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Age; Aging; Aging (artificial); Apnea; Apoptosis; Attenuation; Biotechnology; Cell adhesion & migration; Cyclin-dependent kinase inhibitor p21; Damage; Differentiation; Ethylenediaminetetraacetic acid; Fibroblasts; Genioglossus muscle; Hypoxia; Immunoglobulins; Injuries; Microscopy; Muscles; p53 Protein; Permeability; Polymerase chain reaction; Regeneration; Respiratory tract; Sleep; Sleep apnea; Sleep apnea syndromes; Sleep disorders; Social aspects; Social conditions; Social problems; Stem cells; Tumor proteins; Wound healing; China; Beijing China; United Kingdom > UK; United States > US

Aging of population brings related social problems, such as muscle attenuation and regeneration barriers with increased aging. Muscle repair and regeneration depend on muscle stem cells (MuSCs). Obstructive sleep apnea (OSA) rises in the aging population. OSA leads to hypoxia and upper airway muscle...