NAD+ regulates nucleotide metabolism and genomic DNA replication

• Published in: Nature cell biology Vol. 25; no. 12; pp. 1774 - 1786
• Main Authors: Munk, Sebastian Howen Nesgaard, Merchut-Maya, Joanna Maria, Adelantado Rubio, Alba, Hall, Arnaldur, Pappas, George, Milletti, Giacomo, Lee, MyungHee, Johnsen, Lea Giørtz, Guldberg, Per, Bartek, Jiri, Maya-Mendoza, Apolinar
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 2023
• Subjects: 13/31; 14/19; 14/63; 38/91; 631/337/151/1431; 631/337/1644; 82/58; Biomedical and Life Sciences; Cancer Research; Cell Biology; Developmental Biology; Life Sciences; Medicin och hälsovetenskap; Stem Cells

The intricate orchestration of enzymatic activities involving nicotinamide adenine dinucleotide (NAD + ) is essential for maintaining metabolic homeostasis and preserving genomic integrity. As a co-enzyme, NAD + plays a key role in regulating metabolic pathways, such as glycolysis and Kreb’s cycle....