A Novel Wistar Rat Model of Obesity-Related Nonalcoholic Fatty Liver Disease Induced by Sucrose-Rich Diet

• Published in: Journal of Diabetes Research Vol. 2016; no. 2016; pp. 1 - 10
• Main Authors: Ferrari, Teresa Cristina A., Coimbra, Cândido C., Couto, Claudia A., Leme, Fabíola O. P., Gioda, Carolina R., Leite, Laura H. R., Lima, Maria Luíza R. P., Leite, Virginia H. R.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Analytical chemistry; Animals; Biomarkers - blood; Blood; Blood Glucose - metabolism; Body Mass Index; Carbohydrates; Catalase - metabolism; Cholesterol; Decomposition; Diet; Dietary Sucrose; Disease Models, Animal; Enzymes; Exercise Therapy - methods; Fatty liver; Immunohistochemistry; Insulin - blood; Insulin Resistance; Laboratory animals; Leptin - blood; Lipids - blood; Lipoproteins; Liver - metabolism; Liver - pathology; Liver diseases; Low density lipoproteins; Male; Malondialdehyde - metabolism; Medical examination; Metabolism; Mutation; Non-alcoholic Fatty Liver Disease - blood; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - pathology; Non-alcoholic Fatty Liver Disease - therapy; Obesity; Obesity - blood; Obesity - etiology; Obesity - pathology; Obesity - therapy; Oxidative Stress; Pathogenesis; Proteins; Rats, Wistar; Running; Superoxide Dismutase - metabolism; Time Factors; Brazil; United States > US

The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood, and experimental models are an alternative to study this issue. We investigated the effects of a simple carbohydrate-rich diet on the development of obesity-related NAFLD and the impact of physical training on the...