Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior

• Published in: Journal of psychiatric research Vol. 46; no. 1; pp. 72 - 79
• Main Authors: Roy, Alec, Hodgkinson, Colin A., DeLuca, Vincenzo, Goldman, David, Enoch, Mary-Anne
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.01.2012; Elsevier
• Subjects: Additives; Adult; Adult and adolescent clinical studies; African Americans; Biological and medical sciences; Black or African American; Carrier Proteins - genetics; Carriers; Child; Child Abuse - psychology; Childhood abuse; CRH; CRHR1; CRHR2; CTQ; Female; Gene Frequency; Gene-Environment Interaction; Genes; Genetic Association Studies; Genotype; Hospitals, Veterans; Humans; Logistic Models; Male; Medical sciences; Middle Aged; Polymorphism, Single Nucleotide - genetics; Prevalence; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Sex Factors; Substance dependence; Suicidal behaviour; Suicide; Surveys and Questionnaires; Tacrolimus Binding Proteins - genetics; African Americans; CRH; CTQ; Substance dependence; CRHR1; CRHR2; Hypothalamohypophysoadrenal axis; Corticotropin releasing factor; Risk taking; Suicide; Genetic determinism; Ethnic group; Suicide attempt; Hypothalamic hormone; Addiction; Gene; Risk factor; Early traumatism; Genetics; Hormone releasing factor; African American

Childhood trauma is associated with hypothalamic–pituitary–adrenal (HPA) axis dysregulation. Both factors increase risk for suicidal behavior. Corticotropin releasing hormone (CRH) regulates the HPA axis and its actions are moderated by a high-affinity binding protein (CRHBP). We hypothesized that C...