Overcoming differences: The catalytic mechanism of metallo-β-lactamases

• Published in: FEBS letters Vol. 589; no. 22; pp. 3419 - 3432
• Main Authors: Meini, María-Rocío, Llarrull, Leticia I., Vila, Alejandro J.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 14.11.2015
• Subjects: active sites; Antibiotic resistance; bacteria; Bacteria - drug effects; Bacteria - enzymology; beta-Lactamases - chemistry; beta-Lactamases - metabolism; Biocatalysis; carbapenems; Crystallography, X-Ray; Drug design; Drug Resistance, Microbial; drugs; enzymes; genes; Humans; Hydrolysis; Mechanism; Metallo-β-lactamase; mutagenesis; zinc; Zinc enzyme; Metallo-β-lactamase; Drug design; Zinc enzyme; Mechanism; Antibiotic resistance

Metallo-β-lactamases are the latest resistance mechanism of pathogenic and opportunistic bacteria against carbapenems, considered as last resort drugs. The worldwide spread of genes coding for these enzymes, together with the lack of a clinically useful inhibitor, have raised a sign of alarm. Inhibi...