Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction

Glucose availability is limiting in tumor environments. Zou and colleagues show that reduced glycolytic metabolism in T cells within tumors suppresses expression of the methyltransferase EZH2, which limits production of antitumor effector molecules and enhances T cell apoptosis. Aerobic glycolysis r...

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Published inNature immunology Vol. 17; no. 1; pp. 95 - 103
Main Authors Zhao, Ende, Maj, Tomasz, Kryczek, Ilona, Li, Wei, Wu, Ke, Zhao, Lili, Wei, Shuang, Crespo, Joel, Wan, Shanshan, Vatan, Linda, Szeliga, Wojciech, Shao, Irene, Wang, Yin, Liu, Yan, Varambally, Sooryanarayana, Chinnaiyan, Arul M, Welling, Theodore H, Marquez, Victor, Kotarski, Jan, Wang, Hongbo, Wang, Zehua, Zhang, Yi, Liu, Rebecca, Wang, Guobin, Zou, Weiping
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.01.2016
Nature Publishing Group
Subjects
13/1
13/106
13/109
13/2
13/21
13/31
13/44
13/51
13/89
13/95
631/250/1619/554/1834/1269
631/250/2502/2170
631/250/580/1884
64/60
82/51
82/80
96/106
96/109
Animals
Biomedicine
Cell metabolism
Cell Separation
Chromatin Immunoprecipitation
Development and progression
Enhancer of Zeste Homolog 2 Protein
Female
Flow Cytometry
Fluorescent Antibody Technique
Gene Expression Regulation, Neoplastic - immunology
Genetic aspects
Glycolysis
Humans
Immunoblotting
Immunology
Infectious Diseases
Melanoma, Experimental - immunology
Mice, Inbred C57BL
MicroRNA
MicroRNAs
Neoplasms - immunology
Ovarian cancer
Ovarian Neoplasms - immunology
Polycomb Repressive Complex 2 - immunology
Properties
Real-Time Polymerase Chain Reaction
T cells
T-Lymphocytes - immunology
Tissue Array Analysis
Transfection
Tumor Escape - immunology
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Abstract Glucose availability is limiting in tumor environments. Zou and colleagues show that reduced glycolytic metabolism in T cells within tumors suppresses expression of the methyltransferase EZH2, which limits production of antitumor effector molecules and enhances T cell apoptosis. Aerobic glycolysis regulates T cell function. However, whether and how primary cancer alters T cell glycolytic metabolism and affects tumor immunity in cancer patients remains a question. Here we found that ovarian cancers imposed glucose restriction on T cells and dampened their function via maintaining high expression of microRNAs miR-101 and miR-26a, which constrained expression of the methyltransferase EZH2. EZH2 activated the Notch pathway by suppressing Notch repressors Numb and Fbxw7 via trimethylation of histone H3 at Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their survival via Bcl-2 signaling. Moreover, small hairpin RNA–mediated knockdown of human EZH2 in T cells elicited poor antitumor immunity. EZH2 + CD8 + T cells were associated with improved survival in patients. Together, these data unveil a metabolic target and mechanism of cancer immune evasion.
AbstractList Aerobic glycolysis regulates T cell function. However, whether and how primary cancer alters T cell glycolytic metabolism and affects tumor immunity in cancer patients remains a question. Here we found that ovarian cancers imposed glucose restriction on T cells and dampened their function via maintaining high expression of microRNAs miR-101 and miR-26a, which constrained expression of the methyltransferase EZH2. EZH2 activated the Notch pathway by suppressing Notch repressors Numb and Fbxw7 via trimethylation of histone H3 at Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their survival via Bcl-2 signaling. Moreover, small hairpin RNA-mediated knockdown of human EZH2 in T cells elicited poor antitumor immunity. EZH2(+)CD8(+) T cells were associated with improved survival in patients. Together, these data unveil a metabolic target and mechanism of cancer immune evasion.
Aerobic glycolysis regulates T cell function. However, if and how primary cancer alters T cell glycolytic metabolism and affects tumor immunity remains a question in cancer patients. Here we report that ovarian cancers imposed glucose restriction on T cells and dampened their function via maintaining high expression of microRNA101 and microRNA26a, which constrained expression of the methyltransferase EZH2. EZH2 activated the Notch pathway by suppressing Notch repressors, Numb and Fbxw7, via H3K27me3, and consequently stimulated T cell polyfunctional cytokine expression and promoted their survival via Bcl-2 signaling. Moreover, human shRNA-knockdown- EZH2 -deficient T cells elicited poor anti-tumor immunity. EZH2 + CD8 + T cells were associated with improved cancer patient survival. Together, the data unveil a novel metabolic target and mechanism of cancer immune evasion.
Aerobic glycolysis regulates T cell function. However, whether and how primary cancer alters T cell glycolytic metabolism and affects tumor immunity in cancer patients remains a question. Here we found that ovarian cancers imposed glucose restriction on T cells and dampened their function via maintaining high expression of microRNAs miR-101 and miR-26a, which constrained expression of the methyltransferase EZH2. EZH2 activated the Notch pathway by suppressing Notch repressors Numb and Fbxw7 via trimethylation of histone H3 at Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their survival via Bcl-2 signaling. Moreover, small hairpin RNA-mediated knockdown of human EZH2 in T cells elicited poor antitumor immunity. EZH2 super(+)CD8 super(+) T cells were associated with improved survival in patients. Together, these data unveil a metabolic target and mechanism of cancer immune evasion.
Aerobic glycolysis regulates T cell function. However, whether and how primary cancer alters T cell glycolytic metabolism and affects tumor immunity in cancer patients remains a question. Here we found that ovarian cancers imposed glucose restriction on T cells and dampened their function via maintaining high expression of microRNAs miR-101 and miR-26a, which constrained expression of the methyltransferase EZH2. EZH2 activated the Notch pathway by suppressing Notch repressors Numb and Fbxw7 via trimethylation of histone H3 at Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their survival via Bcl-2 signaling. Moreover, small hairpin RNA-mediated knockdown of human EZH2 in T cells elicited poor antitumor immunity. [EZH2.sup.+][CD8.sup.+] T cells were associated with improved survival in patients. Together, these data unveil a metabolic target and mechanism of cancer immune evasion.
Glucose availability is limiting in tumor environments. Zou and colleagues show that reduced glycolytic metabolism in T cells within tumors suppresses expression of the methyltransferase EZH2, which limits production of antitumor effector molecules and enhances T cell apoptosis. Aerobic glycolysis regulates T cell function. However, whether and how primary cancer alters T cell glycolytic metabolism and affects tumor immunity in cancer patients remains a question. Here we found that ovarian cancers imposed glucose restriction on T cells and dampened their function via maintaining high expression of microRNAs miR-101 and miR-26a, which constrained expression of the methyltransferase EZH2. EZH2 activated the Notch pathway by suppressing Notch repressors Numb and Fbxw7 via trimethylation of histone H3 at Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their survival via Bcl-2 signaling. Moreover, small hairpin RNA–mediated knockdown of human EZH2 in T cells elicited poor antitumor immunity. EZH2 + CD8 + T cells were associated with improved survival in patients. Together, these data unveil a metabolic target and mechanism of cancer immune evasion.
Audience Academic
Author Wan, Shanshan
Kryczek, Ilona
Wang, Hongbo
Zhao, Ende
Wang, Yin
Li, Wei
Zhao, Lili
Zhang, Yi
Wang, Zehua
Shao, Irene
Liu, Rebecca
Chinnaiyan, Arul M
Kotarski, Jan
Zou, Weiping
Maj, Tomasz
Wu, Ke
Crespo, Joel
Varambally, Sooryanarayana
Vatan, Linda
Welling, Theodore H
Szeliga, Wojciech
Marquez, Victor
Liu, Yan
Wei, Shuang
Wang, Guobin
AuthorAffiliation 1 Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI
3 Department of Biostatistics, University of Michigan School of Medicine, Ann Arbor, MI
6 The First Department of Gynecologic Oncology and Gynecology, Medical University of Lublin, Poland, 20-081
7 Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI
2 Departments of Surgery, and Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
4 Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI
9 Graduate Programs in Immunology and Cancer Biology, University of Michigan, Ann Arbor, MI
10 Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI
5 Chemical Biology Laboratory, Center for Cancer Research, NCI-Frederick, Frederick, Maryland
8 Department of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, MI
AuthorAffiliation_xml – name: 6 The First Department of Gynecologic Oncology and Gynecology, Medical University of Lublin, Poland, 20-081
– name: 9 Graduate Programs in Immunology and Cancer Biology, University of Michigan, Ann Arbor, MI
– name: 1 Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI
– name: 5 Chemical Biology Laboratory, Center for Cancer Research, NCI-Frederick, Frederick, Maryland
– name: 4 Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI
– name: 7 Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI
– name: 10 Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI
– name: 3 Department of Biostatistics, University of Michigan School of Medicine, Ann Arbor, MI
– name: 2 Departments of Surgery, and Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
– name: 8 Department of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, MI
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/26523864$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1084/jem.20050930
10.1038/ni.2687
10.1126/scitranslmed.3002949
10.1084/jem.20070784
10.1126/science.1076997
10.1016/j.immuni.2011.09.019
10.1038/nature11606
10.1111/j.0006-341X.2000.00337.x
10.1038/nrc2355
10.1038/nm.2446
10.1182/blood-2004-06-2482
10.1126/science.1165395
10.1182/blood-2009-03-213496
10.1016/j.immuni.2012.11.021
10.1074/jbc.M105245200
10.1016/j.coi.2012.12.003
10.1146/annurev.immunol.22.012703.104554
10.4049/jimmunol.1302943
10.1016/S0092-8674(04)00451-9
10.1182/blood-2008-03-147645
10.1126/scitranslmed.3003761
10.1016/j.immuni.2014.03.010
10.1084/jem.20120342
10.1016/j.cell.2008.07.049
10.1093/biomet/80.3.557
10.1016/j.cell.2013.05.016
10.1084/jem.20082292
10.1101/gad.1524107
10.1038/nm1093
10.1084/jem.20062363
10.1016/j.immuni.2013.09.015
10.1038/nm1201-1339
10.1038/nm863
10.1038/nri2742
10.4161/onci.19440
10.1038/nature04431
10.1038/ni1234
10.1038/nature01075
10.1038/ni.2035
10.1126/science.1129139
10.1002/ijc.25967
10.1056/NEJMoa051424
10.1016/j.immuni.2013.09.012
10.1056/NEJMoa020177
10.1084/jem.20071331
10.1074/jbc.M103992200
10.1038/nri2619
10.1158/1535-7163.MCT-09-0013
10.1182/blood-2009-03-208249
10.1016/j.immuni.2013.08.025
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References Pagès (CR15) 2005; 353
Kryczek (CR44) 2006; 203
Gaucher (CR4) 2008; 205
Ahmed, Bevan, Reiner, Fearon (CR33) 2009; 9
Marrack, Kappler (CR18) 2004; 22
Yang (CR39) 2013; 39
Tong (CR14) 2014; 192
McCabe (CR21) 2012; 492
Varambally (CR27) 2008; 322
Harari (CR3) 2008; 205
Heagerty, Lumley, Pepe (CR31) 2000; 56
Wei, Zhao, Kryczek, Zou (CR38) 2012; 1
Zheng, Zha, Driessens, Locke, Gajewski (CR7) 2012; 209
Wirtz–Peitz, Nishimura, Knoblich (CR24) 2008; 135
Oberg (CR25) 2001; 276
Yamamoto (CR48) 2001; 276
Crespo, Sun, Welling, Tian, Zou (CR8) 2013; 25
Precopio (CR5) 2007; 204
Zou (CR46) 2001; 7
Kryczek (CR49) 2014; 40
Scholler (CR32) 2012; 4
Cao (CR12) 2002; 298
Fiskus (CR43) 2009; 114
Kryczek (CR19) 2011; 3
Almeida (CR2) 2007; 204
Zou, Restifo (CR36) 2010; 10
Amsen (CR23) 2004; 117
Tumes (CR13) 2013; 39
Gubser (CR9) 2013; 14
Curiel (CR29) 2004; 10
Curiel (CR45) 2003; 9
Varambally (CR41) 2002; 419
Zhang (CR16) 2003; 348
Cui (CR26) 2013; 39
Wherry (CR6) 2011; 12
Miranda (CR20) 2009; 8
Gattinoni (CR35) 2011; 17
Kryczek (CR17) 2009; 114
Lin, Wei, Ying (CR50) 1993; 80
Tan (CR42) 2007; 21
Chang (CR10) 2013; 153
Ciofani, Zuniga–Pflucker (CR22) 2005; 6
Sander (CR28) 2008; 112
Powell, Dudley, Robbins, Rosenberg (CR37) 2005; 105
Muranski (CR40) 2011; 35
Ladell (CR1) 2013; 38
Viré (CR11) 2006; 439
Kryczek (CR47) 2012; 130
Galon (CR30) 2006; 313
Rosenberg, Restifo, Yang, Morgan, Dudley (CR34) 2008; 8
26681461 - Nat Immunol. 2016 Jan;17(1):41-2
S Sander (BFni3313_CR28) 2008; 112
Q Tong (BFni3313_CR14) 2014; 192
F Wirtz–Peitz (BFni3313_CR24) 2008; 135
D Gaucher (BFni3313_CR4) 2008; 205
L Zhang (BFni3313_CR16) 2003; 348
J Galon (BFni3313_CR30) 2006; 313
Y Zheng (BFni3313_CR7) 2012; 209
J Scholler (BFni3313_CR32) 2012; 4
EJ Wherry (BFni3313_CR6) 2011; 12
E Viré (BFni3313_CR11) 2006; 439
DJ Tumes (BFni3313_CR13) 2013; 39
PJ Heagerty (BFni3313_CR31) 2000; 56
I Kryczek (BFni3313_CR47) 2012; 130
D Amsen (BFni3313_CR23) 2004; 117
J Tan (BFni3313_CR42) 2007; 21
ML Precopio (BFni3313_CR5) 2007; 204
N Yamamoto (BFni3313_CR48) 2001; 276
J Crespo (BFni3313_CR8) 2013; 25
I Kryczek (BFni3313_CR44) 2006; 203
TX Cui (BFni3313_CR26) 2013; 39
SA Rosenberg (BFni3313_CR34) 2008; 8
DY Lin (BFni3313_CR50) 1993; 80
I Kryczek (BFni3313_CR17) 2009; 114
K Yang (BFni3313_CR39) 2013; 39
I Kryczek (BFni3313_CR19) 2011; 3
S Wei (BFni3313_CR38) 2012; 1
P Muranski (BFni3313_CR40) 2011; 35
W Fiskus (BFni3313_CR43) 2009; 114
JR Almeida (BFni3313_CR2) 2007; 204
M Ciofani (BFni3313_CR22) 2005; 6
P Marrack (BFni3313_CR18) 2004; 22
L Gattinoni (BFni3313_CR35) 2011; 17
F Pagès (BFni3313_CR15) 2005; 353
TJ Curiel (BFni3313_CR29) 2004; 10
PM Gubser (BFni3313_CR9) 2013; 14
R Cao (BFni3313_CR12) 2002; 298
I Kryczek (BFni3313_CR49) 2014; 40
S Varambally (BFni3313_CR41) 2002; 419
W Zou (BFni3313_CR36) 2010; 10
W Zou (BFni3313_CR46) 2001; 7
TJ Curiel (BFni3313_CR45) 2003; 9
A Harari (BFni3313_CR3) 2008; 205
DJ Powell Jr. (BFni3313_CR37) 2005; 105
CH Chang (BFni3313_CR10) 2013; 153
MT McCabe (BFni3313_CR21) 2012; 492
R Ahmed (BFni3313_CR33) 2009; 9
S Varambally (BFni3313_CR27) 2008; 322
C Oberg (BFni3313_CR25) 2001; 276
K Ladell (BFni3313_CR1) 2013; 38
TB Miranda (BFni3313_CR20) 2009; 8
References_xml – volume: 203
  start-page: 871
  year: 2006
  end-page: 881
  ident: CR44
  article-title: B7–H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20050930
  contributor:
    fullname: Kryczek
– volume: 14
  start-page: 1064
  year: 2013
  end-page: 1072
  ident: CR9
  article-title: Rapid effector function of memory CD8 T cells requires an immediate-early glycolytic switch
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2687
  contributor:
    fullname: Gubser
– volume: 3
  start-page: 104ra100
  year: 2011
  ident: CR19
  article-title: Human T 17 cells are long–lived effector memory cells
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3002949
  contributor:
    fullname: Kryczek
– volume: 204
  start-page: 2473
  year: 2007
  end-page: 2485
  ident: CR2
  article-title: Superior control of HIV–1 replication by CD8 T cells is reflected by their avidity, polyfunctionality, and clonal turnover
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20070784
  contributor:
    fullname: Almeida
– volume: 298
  start-page: 1039
  year: 2002
  end-page: 1043
  ident: CR12
  article-title: Role of histone H3 lysine 27 methylation in Polycomb-group silencing
  publication-title: Science
  doi: 10.1126/science.1076997
  contributor:
    fullname: Cao
– volume: 35
  start-page: 972
  year: 2011
  end-page: 985
  ident: CR40
  article-title: Th17 cells are long lived and retain a stem cell–like molecular signature
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.09.019
  contributor:
    fullname: Muranski
– volume: 492
  start-page: 108
  year: 2012
  end-page: 112
  ident: CR21
  article-title: EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
  publication-title: Nature
  doi: 10.1038/nature11606
  contributor:
    fullname: McCabe
– volume: 56
  start-page: 337
  year: 2000
  end-page: 344
  ident: CR31
  article-title: Time-dependent ROC curves for censored survival data and a diagnostic marker
  publication-title: Biometrics
  doi: 10.1111/j.0006-341X.2000.00337.x
  contributor:
    fullname: Pepe
– volume: 8
  start-page: 299
  year: 2008
  end-page: 308
  ident: CR34
  article-title: Adoptive cell transfer: a clinical path to effective cancer immunotherapy
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2355
  contributor:
    fullname: Dudley
– volume: 17
  start-page: 1290
  year: 2011
  end-page: 1297
  ident: CR35
  article-title: A human memory T cell subset with stem cell–like properties
  publication-title: Nat. Med.
  doi: 10.1038/nm.2446
  contributor:
    fullname: Gattinoni
– volume: 105
  start-page: 241
  year: 2005
  end-page: 250
  ident: CR37
  article-title: Transition of late-stage effector T cells to CD27 CD28 tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy
  publication-title: Blood
  doi: 10.1182/blood-2004-06-2482
  contributor:
    fullname: Rosenberg
– volume: 322
  start-page: 1695
  year: 2008
  end-page: 1699
  ident: CR27
  article-title: Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
  publication-title: Science
  doi: 10.1126/science.1165395
  contributor:
    fullname: Varambally
– volume: 114
  start-page: 2733
  year: 2009
  end-page: 2743
  ident: CR43
  article-title: Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3–deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
  publication-title: Blood
  doi: 10.1182/blood-2009-03-213496
  contributor:
    fullname: Fiskus
– volume: 38
  start-page: 425
  year: 2013
  end-page: 436
  ident: CR1
  article-title: A molecular basis for the control of preimmune escape variants by HIV–specific CD8 T cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.11.021
  contributor:
    fullname: Ladell
– volume: 276
  start-page: 45031
  year: 2001
  end-page: 45040
  ident: CR48
  article-title: Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M105245200
  contributor:
    fullname: Yamamoto
– volume: 25
  start-page: 214
  year: 2013
  end-page: 221
  ident: CR8
  article-title: T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2012.12.003
  contributor:
    fullname: Zou
– volume: 22
  start-page: 765
  year: 2004
  end-page: 787
  ident: CR18
  article-title: Control of T cell viability
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.22.012703.104554
  contributor:
    fullname: Kappler
– volume: 192
  start-page: 5012
  year: 2014
  end-page: 5022
  ident: CR14
  article-title: Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1302943
  contributor:
    fullname: Tong
– volume: 117
  start-page: 515
  year: 2004
  end-page: 526
  ident: CR23
  article-title: Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
  publication-title: Cell
  doi: 10.1016/S0092-8674(04)00451-9
  contributor:
    fullname: Amsen
– volume: 112
  start-page: 4202
  year: 2008
  end-page: 4212
  ident: CR28
  article-title: MYC stimulates EZH2 expression by repression of its negative regulator miR-26a
  publication-title: Blood
  doi: 10.1182/blood-2008-03-147645
  contributor:
    fullname: Sander
– volume: 4
  start-page: 132ra153
  year: 2012
  ident: CR32
  article-title: Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3003761
  contributor:
    fullname: Scholler
– volume: 40
  start-page: 772
  year: 2014
  end-page: 784
  ident: CR49
  article-title: IL–22CD4 T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
  publication-title: Immunity
  doi: 10.1016/j.immuni.2014.03.010
  contributor:
    fullname: Kryczek
– volume: 209
  start-page: 2157
  year: 2012
  end-page: 2163
  ident: CR7
  article-title: Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy and
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20120342
  contributor:
    fullname: Gajewski
– volume: 135
  start-page: 161
  year: 2008
  end-page: 173
  ident: CR24
  article-title: Linking cell cycle to asymmetric division: Aurora–A phosphorylates the Par complex to regulate Numb localization
  publication-title: Cell
  doi: 10.1016/j.cell.2008.07.049
  contributor:
    fullname: Knoblich
– volume: 80
  start-page: 557
  year: 1993
  end-page: 572
  ident: CR50
  article-title: Checking the Cox model with cumulative sums of martingale-based residuals
  publication-title: Biometrika
  doi: 10.1093/biomet/80.3.557
  contributor:
    fullname: Ying
– volume: 153
  start-page: 1239
  year: 2013
  end-page: 1251
  ident: CR10
  article-title: Posttranscriptional control of T cell effector function by aerobic glycolysis
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.016
  contributor:
    fullname: Chang
– volume: 205
  start-page: 3119
  year: 2008
  end-page: 3131
  ident: CR4
  article-title: Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20082292
  contributor:
    fullname: Gaucher
– volume: 21
  start-page: 1050
  year: 2007
  end-page: 1063
  ident: CR42
  article-title: Pharmacologic disruption of Polycomb-repressive complex 2–mediated gene repression selectively induces apoptosis in cancer cells
  publication-title: Genes Dev.
  doi: 10.1101/gad.1524107
  contributor:
    fullname: Tan
– volume: 10
  start-page: 942
  year: 2004
  end-page: 949
  ident: CR29
  article-title: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
  publication-title: Nat. Med.
  doi: 10.1038/nm1093
  contributor:
    fullname: Curiel
– volume: 204
  start-page: 1405
  year: 2007
  end-page: 1416
  ident: CR5
  article-title: Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8 T cell responses
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20062363
  contributor:
    fullname: Precopio
– volume: 39
  start-page: 1043
  year: 2013
  end-page: 1056
  ident: CR39
  article-title: T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.09.015
  contributor:
    fullname: Yang
– volume: 7
  start-page: 1339
  year: 2001
  end-page: 1346
  ident: CR46
  article-title: Stromal–derived factor–1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells
  publication-title: Nat. Med.
  doi: 10.1038/nm1201-1339
  contributor:
    fullname: Zou
– volume: 9
  start-page: 562
  year: 2003
  end-page: 567
  ident: CR45
  article-title: Blockade of B7–H1 improves myeloid dendritic cell–mediated antitumor immunity
  publication-title: Nat. Med.
  doi: 10.1038/nm863
  contributor:
    fullname: Curiel
– volume: 10
  start-page: 248
  year: 2010
  end-page: 256
  ident: CR36
  article-title: TH17 cells in tumour immunity and immunotherapy
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2742
  contributor:
    fullname: Restifo
– volume: 1
  start-page: 516
  year: 2012
  end-page: 519
  ident: CR38
  article-title: Th17 cells have stem cell-like features and promote long-term tumor immunity
  publication-title: OncoImmunology
  doi: 10.4161/onci.19440
  contributor:
    fullname: Zou
– volume: 439
  start-page: 871
  year: 2006
  end-page: 874
  ident: CR11
  article-title: The Polycomb group protein EZH2 directly controls DNA methylation
  publication-title: Nature
  doi: 10.1038/nature04431
  contributor:
    fullname: Viré
– volume: 6
  start-page: 881
  year: 2005
  end-page: 888
  ident: CR22
  article-title: Notch promotes survival of pre–T cells at the beta–selection checkpoint by regulating cellular metabolism
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1234
  contributor:
    fullname: Zuniga–Pflucker
– volume: 419
  start-page: 624
  year: 2002
  end-page: 629
  ident: CR41
  article-title: The Polycomb group protein EZH2 is involved in progression of prostate cancer
  publication-title: Nature
  doi: 10.1038/nature01075
  contributor:
    fullname: Varambally
– volume: 12
  start-page: 492
  year: 2011
  end-page: 499
  ident: CR6
  article-title: T cell exhaustion
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2035
  contributor:
    fullname: Wherry
– volume: 313
  start-page: 1960
  year: 2006
  end-page: 1964
  ident: CR30
  article-title: Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
  publication-title: Science
  doi: 10.1126/science.1129139
  contributor:
    fullname: Galon
– volume: 130
  start-page: 29
  year: 2012
  end-page: 39
  ident: CR47
  article-title: Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.25967
  contributor:
    fullname: Kryczek
– volume: 353
  start-page: 2654
  year: 2005
  end-page: 2666
  ident: CR15
  article-title: Effector memory T cells, early metastasis, and survival in colorectal cancer
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa051424
  contributor:
    fullname: Pagès
– volume: 39
  start-page: 819
  year: 2013
  end-page: 832
  ident: CR13
  article-title: The polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type 1 and type 2 cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.09.012
  contributor:
    fullname: Tumes
– volume: 348
  start-page: 203
  year: 2003
  end-page: 213
  ident: CR16
  article-title: Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa020177
  contributor:
    fullname: Zhang
– volume: 205
  start-page: 63
  year: 2008
  end-page: 77
  ident: CR3
  article-title: An HIV–1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20071331
  contributor:
    fullname: Harari
– volume: 276
  start-page: 35847
  year: 2001
  end-page: 35853
  ident: CR25
  article-title: The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M103992200
  contributor:
    fullname: Oberg
– volume: 9
  start-page: 662
  year: 2009
  end-page: 668
  ident: CR33
  article-title: The precursors of memory: models and controversies
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2619
  contributor:
    fullname: Fearon
– volume: 8
  start-page: 1579
  year: 2009
  end-page: 1588
  ident: CR20
  article-title: DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-09-0013
  contributor:
    fullname: Miranda
– volume: 114
  start-page: 1141
  year: 2009
  end-page: 1149
  ident: CR17
  article-title: Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
  publication-title: Blood
  doi: 10.1182/blood-2009-03-208249
  contributor:
    fullname: Kryczek
– volume: 39
  start-page: 611
  year: 2013
  end-page: 621
  ident: CR26
  article-title: Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.08.025
  contributor:
    fullname: Cui
– volume: 298
  start-page: 1039
  year: 2002
  ident: BFni3313_CR12
  publication-title: Science
  doi: 10.1126/science.1076997
  contributor:
    fullname: R Cao
– volume: 4
  start-page: 132ra153
  year: 2012
  ident: BFni3313_CR32
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3003761
  contributor:
    fullname: J Scholler
– volume: 322
  start-page: 1695
  year: 2008
  ident: BFni3313_CR27
  publication-title: Science
  doi: 10.1126/science.1165395
  contributor:
    fullname: S Varambally
– volume: 10
  start-page: 942
  year: 2004
  ident: BFni3313_CR29
  publication-title: Nat. Med.
  doi: 10.1038/nm1093
  contributor:
    fullname: TJ Curiel
– volume: 25
  start-page: 214
  year: 2013
  ident: BFni3313_CR8
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2012.12.003
  contributor:
    fullname: J Crespo
– volume: 205
  start-page: 3119
  year: 2008
  ident: BFni3313_CR4
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20082292
  contributor:
    fullname: D Gaucher
– volume: 114
  start-page: 1141
  year: 2009
  ident: BFni3313_CR17
  publication-title: Blood
  doi: 10.1182/blood-2009-03-208249
  contributor:
    fullname: I Kryczek
– volume: 203
  start-page: 871
  year: 2006
  ident: BFni3313_CR44
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20050930
  contributor:
    fullname: I Kryczek
– volume: 153
  start-page: 1239
  year: 2013
  ident: BFni3313_CR10
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.016
  contributor:
    fullname: CH Chang
– volume: 192
  start-page: 5012
  year: 2014
  ident: BFni3313_CR14
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1302943
  contributor:
    fullname: Q Tong
– volume: 348
  start-page: 203
  year: 2003
  ident: BFni3313_CR16
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa020177
  contributor:
    fullname: L Zhang
– volume: 10
  start-page: 248
  year: 2010
  ident: BFni3313_CR36
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2742
  contributor:
    fullname: W Zou
– volume: 209
  start-page: 2157
  year: 2012
  ident: BFni3313_CR7
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20120342
  contributor:
    fullname: Y Zheng
– volume: 14
  start-page: 1064
  year: 2013
  ident: BFni3313_CR9
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2687
  contributor:
    fullname: PM Gubser
– volume: 117
  start-page: 515
  year: 2004
  ident: BFni3313_CR23
  publication-title: Cell
  doi: 10.1016/S0092-8674(04)00451-9
  contributor:
    fullname: D Amsen
– volume: 38
  start-page: 425
  year: 2013
  ident: BFni3313_CR1
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.11.021
  contributor:
    fullname: K Ladell
– volume: 35
  start-page: 972
  year: 2011
  ident: BFni3313_CR40
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.09.019
  contributor:
    fullname: P Muranski
– volume: 204
  start-page: 1405
  year: 2007
  ident: BFni3313_CR5
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20062363
  contributor:
    fullname: ML Precopio
– volume: 22
  start-page: 765
  year: 2004
  ident: BFni3313_CR18
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.22.012703.104554
  contributor:
    fullname: P Marrack
– volume: 39
  start-page: 819
  year: 2013
  ident: BFni3313_CR13
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.09.012
  contributor:
    fullname: DJ Tumes
– volume: 39
  start-page: 1043
  year: 2013
  ident: BFni3313_CR39
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.09.015
  contributor:
    fullname: K Yang
– volume: 105
  start-page: 241
  year: 2005
  ident: BFni3313_CR37
  publication-title: Blood
  doi: 10.1182/blood-2004-06-2482
  contributor:
    fullname: DJ Powell Jr.
– volume: 9
  start-page: 662
  year: 2009
  ident: BFni3313_CR33
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2619
  contributor:
    fullname: R Ahmed
– volume: 276
  start-page: 45031
  year: 2001
  ident: BFni3313_CR48
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M105245200
  contributor:
    fullname: N Yamamoto
– volume: 276
  start-page: 35847
  year: 2001
  ident: BFni3313_CR25
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M103992200
  contributor:
    fullname: C Oberg
– volume: 39
  start-page: 611
  year: 2013
  ident: BFni3313_CR26
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.08.025
  contributor:
    fullname: TX Cui
– volume: 7
  start-page: 1339
  year: 2001
  ident: BFni3313_CR46
  publication-title: Nat. Med.
  doi: 10.1038/nm1201-1339
  contributor:
    fullname: W Zou
– volume: 8
  start-page: 299
  year: 2008
  ident: BFni3313_CR34
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2355
  contributor:
    fullname: SA Rosenberg
– volume: 12
  start-page: 492
  year: 2011
  ident: BFni3313_CR6
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2035
  contributor:
    fullname: EJ Wherry
– volume: 80
  start-page: 557
  year: 1993
  ident: BFni3313_CR50
  publication-title: Biometrika
  doi: 10.1093/biomet/80.3.557
  contributor:
    fullname: DY Lin
– volume: 114
  start-page: 2733
  year: 2009
  ident: BFni3313_CR43
  publication-title: Blood
  doi: 10.1182/blood-2009-03-213496
  contributor:
    fullname: W Fiskus
– volume: 3
  start-page: 104ra100
  year: 2011
  ident: BFni3313_CR19
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3002949
  contributor:
    fullname: I Kryczek
– volume: 8
  start-page: 1579
  year: 2009
  ident: BFni3313_CR20
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-09-0013
  contributor:
    fullname: TB Miranda
– volume: 313
  start-page: 1960
  year: 2006
  ident: BFni3313_CR30
  publication-title: Science
  doi: 10.1126/science.1129139
  contributor:
    fullname: J Galon
– volume: 130
  start-page: 29
  year: 2012
  ident: BFni3313_CR47
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.25967
  contributor:
    fullname: I Kryczek
– volume: 17
  start-page: 1290
  year: 2011
  ident: BFni3313_CR35
  publication-title: Nat. Med.
  doi: 10.1038/nm.2446
  contributor:
    fullname: L Gattinoni
– volume: 353
  start-page: 2654
  year: 2005
  ident: BFni3313_CR15
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa051424
  contributor:
    fullname: F Pagès
– volume: 1
  start-page: 516
  year: 2012
  ident: BFni3313_CR38
  publication-title: OncoImmunology
  doi: 10.4161/onci.19440
  contributor:
    fullname: S Wei
– volume: 439
  start-page: 871
  year: 2006
  ident: BFni3313_CR11
  publication-title: Nature
  doi: 10.1038/nature04431
  contributor:
    fullname: E Viré
– volume: 135
  start-page: 161
  year: 2008
  ident: BFni3313_CR24
  publication-title: Cell
  doi: 10.1016/j.cell.2008.07.049
  contributor:
    fullname: F Wirtz–Peitz
– volume: 56
  start-page: 337
  year: 2000
  ident: BFni3313_CR31
  publication-title: Biometrics
  doi: 10.1111/j.0006-341X.2000.00337.x
  contributor:
    fullname: PJ Heagerty
– volume: 9
  start-page: 562
  year: 2003
  ident: BFni3313_CR45
  publication-title: Nat. Med.
  doi: 10.1038/nm863
  contributor:
    fullname: TJ Curiel
– volume: 40
  start-page: 772
  year: 2014
  ident: BFni3313_CR49
  publication-title: Immunity
  doi: 10.1016/j.immuni.2014.03.010
  contributor:
    fullname: I Kryczek
– volume: 204
  start-page: 2473
  year: 2007
  ident: BFni3313_CR2
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20070784
  contributor:
    fullname: JR Almeida
– volume: 112
  start-page: 4202
  year: 2008
  ident: BFni3313_CR28
  publication-title: Blood
  doi: 10.1182/blood-2008-03-147645
  contributor:
    fullname: S Sander
– volume: 205
  start-page: 63
  year: 2008
  ident: BFni3313_CR3
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20071331
  contributor:
    fullname: A Harari
– volume: 419
  start-page: 624
  year: 2002
  ident: BFni3313_CR41
  publication-title: Nature
  doi: 10.1038/nature01075
  contributor:
    fullname: S Varambally
– volume: 21
  start-page: 1050
  year: 2007
  ident: BFni3313_CR42
  publication-title: Genes Dev.
  doi: 10.1101/gad.1524107
  contributor:
    fullname: J Tan
– volume: 492
  start-page: 108
  year: 2012
  ident: BFni3313_CR21
  publication-title: Nature
  doi: 10.1038/nature11606
  contributor:
    fullname: MT McCabe
– volume: 6
  start-page: 881
  year: 2005
  ident: BFni3313_CR22
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1234
  contributor:
    fullname: M Ciofani
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Snippet Glucose availability is limiting in tumor environments. Zou and colleagues show that reduced glycolytic metabolism in T cells within tumors suppresses...
Aerobic glycolysis regulates T cell function. However, whether and how primary cancer alters T cell glycolytic metabolism and affects tumor immunity in cancer...
Aerobic glycolysis regulates T cell function. However, if and how primary cancer alters T cell glycolytic metabolism and affects tumor immunity remains a...
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13/106
13/109
13/2
13/21
13/31
13/44
13/51
13/89
13/95
631/250/1619/554/1834/1269
631/250/2502/2170
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Animals
Biomedicine
Cell metabolism
Cell Separation
Chromatin Immunoprecipitation
Development and progression
Enhancer of Zeste Homolog 2 Protein
Female
Flow Cytometry
Fluorescent Antibody Technique
Gene Expression Regulation, Neoplastic - immunology
Genetic aspects
Glycolysis
Humans
Immunoblotting
Immunology
Infectious Diseases
Melanoma, Experimental - immunology
Mice, Inbred C57BL
MicroRNA
MicroRNAs
Neoplasms - immunology
Ovarian cancer
Ovarian Neoplasms - immunology
Polycomb Repressive Complex 2 - immunology
Properties
Real-Time Polymerase Chain Reaction
T cells
T-Lymphocytes - immunology
Tissue Array Analysis
Transfection
Tumor Escape - immunology
Title Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction
URI https://link.springer.com/article/10.1038/ni.3313
https://www.ncbi.nlm.nih.gov/pubmed/26523864
https://www.proquest.com/docview/1767083597
https://search.proquest.com/docview/1750435876
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https://pubmed.ncbi.nlm.nih.gov/PMC4684796
Volume 17
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