Developmental effects of wheel running on hippocampal glutamate receptor expression in young and mature adult rats

• Published in: Neuroscience Vol. 305; pp. 248 - 256
• Main Authors: Staples, M.C., Somkuwar, S.S., Mandyam, C.D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.10.2015
• Subjects: Age Factors; aging; Aging - physiology; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Circadian Rhythm; dorsal; exercise; Gene Expression Regulation - physiology; GluN receptor; hippocampus; Hippocampus - growth & development; Hippocampus - metabolism; Male; Neurology; Physical Conditioning, Animal - physiology; Rats; Rats, Wistar; Receptors, Glutamate - metabolism; Running - physiology; Statistics as Topic; Time Factors; ventral; dorsal; VH; DH; hippocampus; BDNF; GluN receptor; ventral; LTP; exercise; aging; GluN; ventral hippocampus; dorsal hippocampus; glutamatergic ionotropic N-methyl-d-aspartate receptor; brain-derived neurotrophic factor; long-term potentiation

•Young adult runners escalate running activity.•Age is a factor in the hippocampal GluN response to voluntary wheel running.•GluN response is subregionally distinct within the hippocampus. Recent evidence suggests that the behavioral benefits associated with voluntary wheel running in rodents may be...