Prevalence, Clinical Phenotype, and Outcomes Associated With Normal B-Type Natriuretic Peptide Levels in Heart Failure With Preserved Ejection Fraction

• Published in: The American journal of cardiology Vol. 110; no. 6; pp. 870 - 876
• Main Authors: Anjan, Venkatesh Y., Loftus, Timothy M., Burke, Michael A., Akhter, Nausheen, Fonarow, Gregg C., Gheorghiade, Mihai, Shah, Sanjiv J.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.09.2012; Elsevier; Elsevier Limited
• Subjects: Aged; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cardiovascular system; Clinical trials; Drug therapy; Echocardiography; Female; Follow-Up Studies; Heart; Heart attacks; Heart failure; Heart Failure - blood; Heart Failure - physiopathology; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Hemodynamics; Humans; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Logistic Models; Male; Medical sciences; Middle Aged; Natriuretic Peptide, Brain - blood; Peptides; Prevalence; Prospective Studies; Stroke Volume; Heart failure; Prognosis; Prevalence; Peptides; Cardiovascular disease; Normal; Epidemiology; Phenotype; Type; Heart disease; Level; Circulatory system; Hemodynamics; Cardiology; Ejection fraction

B-type natriuretic peptide (BNP) is used widely to exclude heart failure (HF) in patients with dyspnea. However, most studies of BNP have focused on diagnosing HF with reduced ejection fraction (EF). The aim of this study was to test the hypothesis that a normal BNP level (≤100 pg/ml) is relatively...