Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization

• Published in: International Journal of Molecular Sciences Vol. 24; no. 10; pp. 8500 - 20
• Main Authors: Clavero, Esther, Sanchez-Maldonado, José Manuel, Macauda, Angelica, Ter Horst, Rob, Marques, Maria Belém Sousa Sampaio, Jurczyszyn, Artur, Clay-Gilmour, Alyssa, Stein, Angelika, Hildebrandt, Michelle A. T., Weinhold, Niels, Buda, Gabriele, García-Sanz, Ramón, Tomczak, Waldemar, Vogel, Ulla, Jerez, Andrés, Zawirska, Daria, Wątek, Marzena, Hofmann, Jonathan N., Landi, Stefano, Spinelli, John J., Butrym, Aleksandra, Kumar, Abhishek, Martínez-López, Joaquín, Galimberti, Sara, Sarasquete, María Eugenia, Subocz, Edyta, Iskierka-Jażdżewska, Elzbieta, Giles, Graham G., Rybicka-Ramos, Malwina, Kruszewski, Marcin, Abildgaard, Niels, Verdejo, Francisco García, Sánchez Rovira, Pedro, da Silva Filho, Miguel Inacio, Kadar, Katalin, Razny, Małgorzata, Cozen, Wendy, Pelosini, Matteo, Jurado, Manuel, Bhatti, Parveen, Dudzinski, Marek, Druzd-Sitek, Agnieszka, Orciuolo, Enrico, Li, Yang, Norman, Aaron D., Zaucha, Jan Maciej, Reis, R. M., Markiewicz, Miroslaw, Rodríguez Sevilla, Juan José, Andersen, Vibeke, Jamroziak, Krzysztof, Hemminki, Kari, Berndt, Sonja I., Rajkumar, Vicent, Mazur, Grzegorz, Kumar, Shaji K., Ludovico, Paula, Nagler, Arnon, Chanock, Stephen J., Dumontet, Charles, Machiela, Mitchell J., Varkonyi, Judit, Camp, Nicola J., Ziv, Elad, Vangsted, Annette Juul, Brown, Elizabeth E., Campa, Daniele, Vachon, Celine M., Netea, Mihai G., Canzian, Federico, Försti, Asta, Sainz, Juan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.05.2023; Multidisciplinary Digital Publishing Institute; MDPI
• Subjects: Analysis; Apoptosis; Autofàgia; Autophagy; autophagy; genetic susceptibility; genetic variants; multiple myeloma; B cells; Biological Factors::Biomarkers [CHEMICALS AND DRUGS]; Biomarkers; Bone marrow; Cancer; Cells; Cell Physiological Phenomena::Cell Death::Autophagy [PHENOMENA AND PROCESSES]; Development and progression; Disease susceptibility; enfermedades hematológicas y linfáticas::enfermedades hematológicas::trastornos de las proteínas sanguíneas::paraproteinemias::enfermedades hematológicas y linfáticas::enfermedades hematológicas::mieloma múltiple [ENFERMEDADES]; factores biológicos::biomarcadores [COMPUESTOS QUÍMICOS Y DROGAS]; fenómenos fisiológicos celulares::muerte celular::autofagia [FENÓMENOS Y PROCESOS]; Genes; Genetic aspects; Genetic polymorphisms; Genetic susceptibility; Genetic variants; Hemic and Lymphatic Diseases::Hematologic Diseases::Blood Protein Disorders::Paraproteinemias::Hemic and Lymphatic Diseases::Hematologic Diseases::Multiple Myeloma [DISEASES]; Humans; Immune response; Immunoglobulin M; Immunoglobulins; Independent study; Leukocytes; Leukocytes, Mononuclear; Leukocytes, Mononuclear - pathology; Life Sciences; Marcadors bioquímics; Medical prognosis; Meta-analysis; Mieloma múltiple - Aspectes genètics; Mononuclear/pathology; Multiple myeloma; Multiple Myeloma - genetics; Multiple Myeloma - pathology; multiple myeloma; autophagy; genetic variants; genetic susceptibility; Other subheadings::Other subheadings::/genetics [Other subheadings]; Otros calificadores::Otros calificadores::/genética [Otros calificadores]; Proteins; Radboud University Medical Center; Radboudumc 4: lnfectious Diseases and Global Health Internal Medicine; Denmark; Poland; Canada; Australia; Germany; Spain; genetic variants; multiple myeloma; autophagy; genetic susceptibility

Functional data used in this project have been meticulously catalogued and archived in the BBMRI-NL data infrastructure (https://hfgp.bbmri.nl/, accessed on 12 February 2020) using the MOLGENIS open-source platform for scientific data. Multiple myeloma (MM) arises following malignant proliferation o...