Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity

• Published in: Biomaterials Vol. 140; pp. 45 - 57
• Main Authors: Andresen Eguiluz, Roberto C., Kaylan, Kerim B., Underhill, Gregory H., Leckband, Deborah E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2017
• Subjects: Advanced Basic Science; Antigens, CD - metabolism; Biocompatible Materials - chemistry; Biomechanical Phenomena; cadherins; Cadherins - metabolism; Cell Adhesion; Cell Line; Cell traction; Cell-Matrix Junctions - metabolism; Dentistry; Endothelial Cells - cytology; Endothelial Cells - metabolism; endothelium; Endothelium, Vascular - cytology; Endothelium, Vascular - metabolism; extracellular matrix; focal adhesions; Focal Adhesions - metabolism; Humans; Hydrogels - chemistry; integrins; intercellular junctions; Intercellular Junctions - metabolism; Magnetic twisting cytometry; Mechanotransduction; Mechanotransduction, Cellular; Micropatterned substrates; receptors; shear stress; Stress, Mechanical; VE-cadherin; Magnetic twisting cytometry; Micropatterned substrates; Mechanotransduction; Cell traction; VE-cadherin

The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also activate force transduction signals at intercellular...